Shunt-dependency after aneurysmal subarachnoid haemorrhage – the role of early hyperglycaemia in cerebro-spinal fluid and blood - Project

Project

Shunt-dependency after aneurysmal subarachnoid haemorrhage – the role of early hyperglycaemia in cerebro-spinal fluid and blood

Ongoing - recruitment active · 2024 until 2027

Hostettler Isabel, Wiebe Lauren, Pietsch Urs, Klein Carsten, Keller Mirja, Kälin Vincens, Yildiz Yesim

Type

Clinical Studies

Range

Multicentric, KSSG as main centre

Units

Neurochirurgie, Operative intensive care medicine

Status

Ongoing - recruitment active

Start Date

2024

End Date

2027

Financing

KSSG

Study Design

Prospective, cohort, multicentre study (Canton Hospital St. Gallen, Canton Hospital Aarau, University Hospital Basel)

Keywords

aneurysmal subarachnoid haemorrhage hyperglycaemia hydrocephalus ventriculo-peritoneal shunt extra-ventricular drain lumbar drain

Brief description/objective

Several factors influence morbidity after aneurysmal subarachnoid haemorrhage (aSAH) and therefore also functional outcome. One of these factors is hydrocephalus (HCP) which, in case of unsuccessful weaning from an extraventricular drain (EVD) can lead to ventriculo-peritoneal shunt (VPS) dependency opening further possible complications and therefore increased morbidity. Our aim is to confirm the association of early increased glucose levels in cerebro-spinal fluid (CSF) and VPS-dependency also evaluating the influence of blood glucose on VPS dependency in patients suffering from an aSAH. By confirming, or contradicting, previous findings we aim to finally answer the question about association of hyperglycaemia and VPS-dependency as well as the importance of at which time point elevated glucose levels influence this. This would have clear implications on future clinical management as if hyperglycaemia is indeed established as an influencing factor on VPS dependency this could provide us with a potential target by influencing glucose levels and could lead to early VPS placement instead of repeated EVD replacements. By doing so morbidity could be reduced.