Prof. Dr. med. Stephan Brand
Gastroenterologie | Hepatologie · Dept. I
A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory proteins
Diegelmann J, Olszak T, Göke B, Blumberg R, Brand S. A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory proteins. J Biol Chem 2011; 287:286-98.
08.11.2011A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory proteins
08.11.2011J Biol Chem 2011; 287:286-98
Diegelmann Julia, Olszak Torsten, Göke Burkhard, Blumberg Richard S, Brand Stephan
Homozygosity for the NOD2 p.Leu1007fsX1008 variant is the main genetic predictor for fibrostenotic Crohn's disease
Brand S. Homozygosity for the NOD2 p.Leu1007fsX1008 variant is the main genetic predictor for fibrostenotic Crohn's disease. Inflamm Bowel Dis 2011; 18:393-4.
29.10.2011Homozygosity for the NOD2 p.Leu1007fsX1008 variant is the main genetic predictor for fibrostenotic Crohn's disease
29.10.2011Inflamm Bowel Dis 2011; 18:393-4
Brand Stephan
Dominant disease-causing effect of NOD2 mutations in a family with all family members affected by Crohn's disease
Schnitzler F, Seiderer J, Stallhofer J, Brand S. Dominant disease-causing effect of NOD2 mutations in a family with all family members affected by Crohn's disease. Inflamm Bowel Dis 2011; 18:395-6.
12.10.2011Dominant disease-causing effect of NOD2 mutations in a family with all family members affected by Crohn's disease
12.10.2011Inflamm Bowel Dis 2011; 18:395-6
Schnitzler Fabian, Seiderer Julia, Stallhofer Johannes, Brand Stephan
Malignant melanoma during ustekinumab therapy of Crohn's disease
Ehmann L, Tillack-Schreiber C, Brand S, Wollenberg A. Malignant melanoma during ustekinumab therapy of Crohn's disease. Inflamm Bowel Dis 2011; 18:E199-200.
10.10.2011Malignant melanoma during ustekinumab therapy of Crohn's disease
10.10.2011Inflamm Bowel Dis 2011; 18:E199-200
Ehmann Laura M, Tillack-Schreiber Cornelia, Brand Stephan, Wollenberg Andreas
Infliximab does not affect postoperative complication rates in Crohn's patients undergoing abdominal surgery
Kasparek M, Bruckmeier A, Beigel F, Müller M, Brand S, Mansmann U, Jauch K, Ochsenkühn T, Kreis M. Infliximab does not affect postoperative complication rates in Crohn's patients undergoing abdominal surgery. Inflamm Bowel Dis 2011; 18:1207-13.
16.09.2011Infliximab does not affect postoperative complication rates in Crohn's patients undergoing abdominal surgery
16.09.2011Inflamm Bowel Dis 2011; 18:1207-13
Kasparek Michael S, Bruckmeier Andreas, Beigel Florian, Müller Mario H, Brand Stephan, Mansmann Ulrich, Jauch Karl-Walter, Ochsenkühn Thomas, Kreis Martin E
PSC: Protect and serve with colitis: does it help the liver to have severe ulcerative colitis?
Rust C, Brand S. PSC: Protect and serve with colitis: does it help the liver to have severe ulcerative colitis?. Gut 2011; 60:1165-6.
11.05.2011PSC: Protect and serve with colitis: does it help the liver to have severe ulcerative colitis?
11.05.2011Gut 2011; 60:1165-6
Rust Christian, Brand Stephan
CEACAM6 gene variants in inflammatory bowel disease
Glas J, Czamara D, Diegelmann J, Müller-Myhsok B, Lohse P, Wolf C, Ochsenkühn T, Göke B, Lass U, Olszak T, Beigel F, Weidinger M, Pfennig S, Tillack C, Fries C, Seiderer J, Brand S. CEACAM6 gene variants in inflammatory bowel disease. PloS one 2011; 6:e19319.
29.04.2011CEACAM6 gene variants in inflammatory bowel disease
29.04.2011PloS one 2011; 6:e19319
Glas Jürgen, Czamara Darina, Diegelmann Julia, Müller-Myhsok Bertram, Lohse Peter, Wolf Christiane, Ochsenkühn Thomas, Göke Burkhard, Lass Ulrich, Olszak Torsten, Beigel Florian, Weidinger Maria, Pfennig Simone, Tillack Cornelia, Fries Christoph, Seiderer Julia, Brand Stephan
The novel Raf inhibitor Raf265 decreases Bcl-2 levels and confers TRAIL-sensitivity to neuroendocrine tumour cells
Zitzmann K, de Toni E, von Rüden J, Brand S, Göke B, Laubender R, Auernhammer C. The novel Raf inhibitor Raf265 decreases Bcl-2 levels and confers TRAIL-sensitivity to neuroendocrine tumour cells. Endocr Relat Cancer 2011; 18:277-85.
21.03.2011The novel Raf inhibitor Raf265 decreases Bcl-2 levels and confers TRAIL-sensitivity to neuroendocrine tumour cells
21.03.2011Endocr Relat Cancer 2011; 18:277-85
Zitzmann Kathrin, de Toni Enrico, von Rüden Janina, Brand Stephan, Göke Burkhard, Laubender Rüdiger P, Auernhammer Christoph J
Analysis of IL2/IL21 gene variants in cholestatic liver diseases reveals an association with primary sclerosing cholangitis
Stallhofer J, Denk G, Glas J, Laubender R, Göke B, Rust C, Brand S, Pusl T. Analysis of IL2/IL21 gene variants in cholestatic liver diseases reveals an association with primary sclerosing cholangitis. Digestion 2011; 84:29-35.
08.02.2011Analysis of IL2/IL21 gene variants in cholestatic liver diseases reveals an association with primary sclerosing cholangitis
08.02.2011Digestion 2011; 84:29-35
Stallhofer Johannes, Denk Gerald Ulrich, Glas Jürgen, Laubender Rüdiger Paul, Göke Burkhard, Rust Christian, Brand Stephan, Pusl Thomas
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Phillips A, van den Berg L, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson D, Westra H, Xavier R, Zhao Z, Ponsioen C, Andersen V, Torkvist L, Targan S, Steinhart A, Prescott N, Proctor D, Roberts R, Russell R, Rutgeerts P, Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms L, Seielstad M, Gazouli M, Anagnou N, Satsangi J, Cho J, Schreiber S, Daly M, Barrett J, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr R, Vermeire S, Weersma R, Chamaillard M, Brant S, Karlsen T, Kupcinskas L, Sventoraityte J, Mansfield J, Kugathasan S, Silverberg M, Halfvarson J, Rotter J, Mathew C, Griffiths A, Gearry R, Ahmad T, Rioux J, Panés J, Anderson C, Baldassano R, Barclay M, Bayless T, Brand S, Büning C, Colombel J, Denson L, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann R, Baidoo L, Bumpstead S, Boucher G, Lees C, Franke A, D'Amato M, Taylor K, Lee J, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Floyd J, Florin T, Libioulle C, Louis E, McGovern D, Milla M, Montgomery G, Morley K, Mowat C, Ng A, Newman W, Ophoff R, Papi L, Palmieri O, Levine A, Lemann M, Franchimont D, Franke L, Georges M, Glas J, Glazer N, Guthery S, Haritunians T, Hayward N, Hugot J, Jobin G, Laukens D, Lawrance I, Peyrin-Biroulet L. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 2011; 43:246-52.
06.02.2011Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
06.02.2011Nat Genet 2011; 43:246-52
Phillips Anne, van den Berg Leonard H, Vatn Morten, Verspaget Hein, Walters Thomas, Wijmenga Cisca, Wilson David C, Westra Harm-Jan, Xavier Ramnik J, Zhao Zhen Z, Ponsioen Cyriel Y, Andersen Vibeke, Torkvist Leif, Targan Stephan R, Steinhart A Hillary, Prescott Natalie J, Proctor Deborah D, Roberts Rebecca, Russell Richard, Rutgeerts Paul, Sanderson Jeremy, Sans Miquel, Schumm Philip, Seibold Frank, Sharma Yashoda, Simms Lisa A, Seielstad Mark, Gazouli Maria, Anagnou Nicholas P, Satsangi Jack, Cho Judy H, Schreiber Stefan, Daly Mark J, Barrett Jeffrey C, Parkes Miles, Annese Vito, Hakonarson Hakon, Radford-Smith Graham, Duerr Richard H, Vermeire Severine, Weersma Rinse K, Chamaillard Mathias, Brant Steven R, Karlsen Tom H, Kupcinskas Limas, Sventoraityte Jurgita, Mansfield John C, Kugathasan Subra, Silverberg Mark S, Halfvarson Jonas, Rotter Jerome I, Mathew Christopher G, Griffiths Anne M, Gearry Richard, Ahmad Tariq, Rioux John D, Panés Julián, Anderson Carl A, Baldassano Robert N, Barclay Murray, Bayless Theodore M, Brand Stephan, Büning Carsten, Colombel Jean-Frédéric, Denson Lee A, De Vos Martine, Dubinsky Marla, Edwards Cathryn, Ellinghaus David, Fehrmann Rudolf S N, Baidoo Leonard, Bumpstead Suzannah, Boucher Gabrielle, Lees Charlie W, Franke Andre, D'Amato Mauro, Taylor Kent D, Lee James C, Goyette Philippe, Imielinski Marcin, Latiano Anna, Lagacé Caroline, Scott Regan, Amininejad Leila, Floyd James A B, Florin Timothy, Libioulle Cecile, Louis Edouard, McGovern Dermot P, Milla Monica, Montgomery Grant W, Morley Katherine I, Mowat Craig, Ng Aylwin, Newman William, Ophoff Roel A, Papi Laura, Palmieri Orazio, Levine Arie, Lemann Marc, Franchimont Denis, Franke Lude, Georges Michel, Glas Jürgen, Glazer Nicole L, Guthery Stephen L, Haritunians Talin, Hayward Nicholas K, Hugot Jean-Pierre, Jobin Gilles, Laukens Debby, Lawrance Ian, Peyrin-Biroulet Laurent
Formation of antinuclear and double-strand DNA antibodies and frequency of lupus-like syndrome in anti-TNF-α antibody-treated patients with inflammatory bowel disease
Beigel F, Schnitzler F, Paul Laubender R, Pfennig S, Weidinger M, Göke B, Seiderer J, Ochsenkühn T, Brand S. Formation of antinuclear and double-strand DNA antibodies and frequency of lupus-like syndrome in anti-TNF-α antibody-treated patients with inflammatory bowel disease. Inflamm Bowel Dis 2011; 17:91-8.
01.01.2011Formation of antinuclear and double-strand DNA antibodies and frequency of lupus-like syndrome in anti-TNF-α antibody-treated patients with inflammatory bowel disease
01.01.2011Inflamm Bowel Dis 2011; 17:91-8
Beigel Florian, Schnitzler Fabian, Paul Laubender Rüdiger, Pfennig Simone, Weidinger Maria, Göke Burkhard, Seiderer Julia, Ochsenkühn Thomas, Brand Stephan
The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants
Glas J, Czamara D, Diegelmann J, Lohse P, Ochsenkühn T, Göke B, Müller-Myhsok B, Weidinger M, Laubender R, Olszak T, Jürgens M, Beigel F, Pfennig S, Tillack C, Seiderer J, Brand S. The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants. PloS one 2010; 5:e14466.
30.12.2010The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants
30.12.2010PloS one 2010; 5:e14466
Glas Jürgen, Czamara Darina, Diegelmann Julia, Lohse Peter, Ochsenkühn Thomas, Göke Burkhard, Müller-Myhsok Bertram, Weidinger Maria, Laubender Rüdiger P, Olszak Torsten, Jürgens Matthias, Beigel Florian, Pfennig Simone, Tillack Cornelia, Seiderer Julia, Brand Stephan
Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus
Diegelmann J, Beigel F, Zitzmann K, Kaul A, Göke B, Auernhammer C, Bartenschlager R, Diepolder H, Brand S. Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus. PloS one 2010; 5:e15200.
08.12.2010Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus
08.12.2010PloS one 2010; 5:e15200
Diegelmann Julia, Beigel Florian, Zitzmann Kathrin, Kaul Artur, Göke Burkhard, Auernhammer Christoph J, Bartenschlager Ralf, Diepolder Helmut M, Brand Stephan
Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease
Glas J, Czamara D, Diegelmann J, Müller-Myhsok B, Folwaczny M, Ochsenkühn T, Göke B, Weidinger M, Olszak T, Beigel F, Wetzke M, Pfennig S, Tengler B, Fischer D, Seiderer J, Brand S. Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease. Inflamm Bowel Dis 2010; 17:1917-24.
03.12.2010Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease
03.12.2010Inflamm Bowel Dis 2010; 17:1917-24
Glas Jürgen, Czamara Darina, Diegelmann Julia, Müller-Myhsok Bertram, Folwaczny Matthias, Ochsenkühn Thomas, Göke Burkhard, Weidinger Maria, Olszak Torsten, Beigel Florian, Wetzke Martin, Pfennig Simone, Tengler Barbara, Fischer Daniel, Seiderer Julia, Brand Stephan
Functional SFTPD gene variants are not associated with susceptibility to inflammatory bowel disease in the German population
Glas J, Seiderer J, Tillack C, Paschos E, Wetzke M, Diegelmann J, Czamara D, Brand S. Functional SFTPD gene variants are not associated with susceptibility to inflammatory bowel disease in the German population. Inflamm Bowel Dis 2010; 17:1439-40.
03.12.2010Functional SFTPD gene variants are not associated with susceptibility to inflammatory bowel disease in the German population
03.12.2010Inflamm Bowel Dis 2010; 17:1439-40
Glas Jürgen, Seiderer Julia, Tillack Cornelia, Paschos Ekaterini, Wetzke Martin, Diegelmann Julia, Czamara Darina, Brand Stephan
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
Glas J, Mowat C, Newman W, Panés J, Phillips A, Proctor D, Regueiro M, Russell R, Rutgeerts P, Sanderson J, Sans M, Louis E, Libioulle C, Van Gossum A, Guthery S, Halfvarson J, Verspaget H, Hugot J, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Seibold F, Steinhart A, Mansfield J, Vermeire S, Duerr R, Silverberg M, Satsangi J, Schreiber S, Cho J, Annese V, Hakonarson H, Daly M, Griffiths A, Kugathasan S, Stokkers P, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan S, Brant S, Rioux J, D'Amato M, Weersma R, Parkes M, Franke A, Ellinghaus D, Festen E, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew C, Montgomery G, Prescott N, Bumpstead S, Bis J, McGovern D, Barrett J, Wang K, Radford-Smith G, Ahmad T, Lees C, Balschun T, Lee J, Roberts R, Anderson C, Raychaudhuri S, Rotter J, Colombel J, Cottone M, Stronati L, Denson T, De Vos M, D'Inca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Cohen A, Büning C, Schumm P, Sharma Y, Simms L, Taylor K, Whiteman D, Wijmenga C, Baldassano R, Barclay M, Bayless T, Brand S, Gearry R. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 2010; 42:1118-25.
01.12.2010Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
01.12.2010Nat Genet 2010; 42:1118-25
Glas Jürgen, Mowat Craig, Newman William, Panés Julián, Phillips Anne, Proctor Deborah D, Regueiro Miguel, Russell Richard, Rutgeerts Paul, Sanderson Jeremy, Sans Miquel, Louis Edouard, Libioulle Cecile, Van Gossum Andre, Guthery Stephen L, Halfvarson Jonas, Verspaget Hein W, Hugot Jean-Pierre, Karban Amir, Laukens Debby, Lawrance Ian, Lemann Marc, Levine Arie, Seibold Frank, Steinhart A Hillary, Mansfield John C, Vermeire Severine, Duerr Richard H, Silverberg Mark S, Satsangi Jack, Schreiber Stefan, Cho Judy H, Annese Vito, Hakonarson Hakon, Daly Mark J, Griffiths Anne M, Kugathasan Subra, Stokkers Pieter C F, Torkvist Leif, Kullak-Ublick Gerd, Wilson David, Walters Thomas, Targan Stephan R, Brant Steven R, Rioux John D, D'Amato Mauro, Weersma Rinse K, Parkes Miles, Franke Andre, Ellinghaus David, Festen Eleonora M, Georges Michel, Green Todd, Haritunians Talin, Jostins Luke, Latiano Anna, Mathew Christopher G, Montgomery Grant W, Prescott Natalie J, Bumpstead Suzanne, Bis Joshua C, McGovern Dermot P B, Barrett Jeffrey C, Wang Kai, Radford-Smith Graham L, Ahmad Tariq, Lees Charlie W, Balschun Tobias, Lee James, Roberts Rebecca, Anderson Carl A, Raychaudhuri Soumya, Rotter Jerome I, Colombel Jean-Frederick, Cottone Mario, Stronati Laura, Denson Ted, De Vos Martine, D'Inca Renata, Dubinsky Marla, Edwards Cathryn, Florin Tim, Franchimont Denis, Cohen Albert, Büning Carsten, Schumm Philip, Sharma Yashoda, Simms Lisa A, Taylor Kent D, Whiteman David, Wijmenga Cisca, Baldassano Robert N, Barclay Murray, Bayless Theodore M, Brand Stephan, Gearry Richard
Expression and regulation of the chemokine CXCL16 in Crohn's disease and models of intestinal inflammation
Diegelmann J, Seiderer J, Niess J, Haller D, Göke B, Reinecker H, Brand S. Expression and regulation of the chemokine CXCL16 in Crohn's disease and models of intestinal inflammation. Inflamm Bowel Dis 2010; 16:1871-81.
01.11.2010Expression and regulation of the chemokine CXCL16 in Crohn's disease and models of intestinal inflammation
01.11.2010Inflamm Bowel Dis 2010; 16:1871-81
Diegelmann Julia, Seiderer Julia, Niess Jan-Hendrik, Haller Dirk, Göke Burkhard, Reinecker Hans-Christian, Brand Stephan
Strong overexpression of CXCR3 axis components in childhood inflammatory bowel disease
Schroepf S, Koletzko S, von Schweinitz D, Berger M, Ballauff A, Helmbrecht J, Hoster E, Glas J, Lohse P, Prell C, Brand S, Kappler R, Lacher M. Strong overexpression of CXCR3 axis components in childhood inflammatory bowel disease. Inflamm Bowel Dis 2010; 16:1882-90.
01.11.2010Strong overexpression of CXCR3 axis components in childhood inflammatory bowel disease
01.11.2010Inflamm Bowel Dis 2010; 16:1882-90
Schroepf Sebastian, Koletzko Sibylle, von Schweinitz Dietrich, Berger Michael, Ballauff Antje, Helmbrecht Johanna, Hoster Eva, Glas Jürgen, Lohse Peter, Prell Christine, Brand Stephan, Kappler Roland, Lacher Martin
Consolidation of evidence for association of the KIAA1109-TENR-IL2-IL21 rs6822844 variant with Crohn’s disease
Glas J, Brand S. Consolidation of evidence for association of the KIAA1109-TENR-IL2-IL21 rs6822844 variant with Crohn’s disease. Am J Gastroenterol 2010:1206-1207.
04.10.2010Consolidation of evidence for association of the KIAA1109-TENR-IL2-IL21 rs6822844 variant with Crohn’s disease
04.10.2010Am J Gastroenterol 2010:1206-1207
Glas J, Brand Stephan
Safety of adalimumab in Crohn's disease during pregnancy: case report and review of the literature
Jürgens M, Ochsenkühn T, Göke B, Tillack C, Beigel F, Hasbargen U, Hübener C, Filik L, Brand S, Seiderer J. Safety of adalimumab in Crohn's disease during pregnancy: case report and review of the literature. Inflamm Bowel Dis 2010; 16:1634-6.
01.10.2010Safety of adalimumab in Crohn's disease during pregnancy: case report and review of the literature
01.10.2010Inflamm Bowel Dis 2010; 16:1634-6
Jürgens Matthias, Ochsenkühn Thomas, Göke Burkhard, Tillack Cornelia, Beigel Florian, Hasbargen Uwe, Hübener Christoph, Filik Levent, Brand Stephan, Seiderer Julia