Projekte
Suche in 1157 Projekten:
1157 Projekt(e)
Decision Making in Oncology - Transfer of Competencies between HSG-KSSG
01.03.2018Decision making in medicine is a very complex process and of central importance to the patient and physician in oncology. Our previous work (based at KSSG) has demonstrated a wide variability in expert decision making in oncology (including the use o...
Grundlagenforschung - 01.03.2018 - 31.12.2020
Automatisch geschlossen
Projektleitung: Putora Paul Martin
TRIANGLE: autologous Transplantation after a Rituxi-mab/Ibrutinib/Ara-c containing iNduction in Generalized mantle cell Lymphoma – a randomized European mcl net-work trial
20.02.2018According to current European guidelines (Dreyling, Ann Oncol 2014), the standard of care in younger patients with mantle cell lymphoma (MCL) is a dose-intensified approach with a cytarabine containing immunochemotherapy induction followed by autolog...
Klinische Forschung - 20.02.2018 - 31.01.2028
Laufend
Projektleitung: Hitz Felicitas
Asthma control Prediction
01.02.2018The project consists of two stages with different objectives. In the first stage, the objective is to investigate whether nocturnal cough occurs in asthmatics more frequently than random (i.e. average nocturnal cough rate significantly greater than z...
Klinische Forschung - 01.02.2018 - 31.12.2018
Automatisch geschlossen
Projektleitung: Rassouli Frank
Mitarbeiter/innen: Brutsche Martin, Baty Florent, Widmer Sandra, Tschirren Ursina
Neural Biomarkers of ADHD, and ADD in the Auditory Cortex of Adults – A controlled cross-sectional observational study
31.01.2018Attention deficit (hyperactivity) disorder (AD(H)D) is one of the most common behavioral disorders in children and adolescents, with a worldwide prevalence of about 5% (Polanczyk et al., 2007; American Psychiatric Association, 2013). A substantial p...
Grundlagenforschung - 31.01.2018 - 01.07.2019
Automatisch geschlossen
Projektleitung: Serrallach Bettina
Skippain
29.01.2018SKIPPAIN (Speed of onset of SecuKinumab-Induced relief from Pain in Patients with AxIal SpoNdyloarthritis) A 24-week, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of secukinumab in controlling sp...
Klinische Forschung - 29.01.2018 - 29.06.2019
Abgeschlossen
Projektleitung: Rubbert-Roth Andrea
Mitarbeiter/innen: Hutz Carina Liane, Forrer Silvia, Bartz-Batliner Mira
Dissecting the association of anti-microbiota antibodies and auto-reactive T-cells in cardiomyopathy– an exploratory research Project
25.01.2018Prospective research project in which biological material is sampled from humans and health-related personal data is collected (HFV Art 6). To generate further scientific evidence for a potential role of crossreactive antimicrobial T and B cell respo...
Klinische Forschung - 25.01.2018 - 25.08.2021
Abgeschlossen
Projektleitung: Ludewig Burkhard
Mitarbeiter/innen: Maeder Micha, Vetsch Susanne
Protocol SAKK 07/17: Nivolumab in combination with I-pilimumab in patients with metastatic renal cell carcinoma: A multicentre single-arm phase lI trial
04.01.2018Superior overall survival of PD-1 blockade with nivolumab compared to everolimus has been shown in the phase III Checkmate-025 trial in metastatic clear cell carcinoma of the kidney in second line after progression under first line therapy with a tyr...
Klinische Forschung - 04.01.2018 - 31.10.2021
Automatisch geschlossen
Projektleitung: Rothermundt Christian
Effect of induction chemotherapy on lung function measured by spiroergometry and 6-Minute walking test in patients affected by non-small cell lung cancer (NSCLC)
01.01.2018Lung cancer is one of the most common cancers in the world and the leading cause of cancer-related mortality. At diagnosis, approximately 40% of patients are already at an advanced stage, and a third have locally advanced disease (stage III). Stage I...
Grundlagenforschung - 01.01.2018 - 31.12.2020
Automatisch geschlossen
Mitarbeiter/innen: Baty Florent, Brutsche Martin, Kern Lukas, Maeder Micha, Früh Martin
Neuropeptide Y NPY-Trial bei Phäochromozytom
01.01.2018Mesure des taux circulants des métabolites du neuropeptide Y chez les volontaires sains, patients hypertendus et patients atteints d’une tumeur neuroendocrine dans le plasma par une nouvelle méthode analytique utilisant la chromatographie liquide cou...
Klinische Forschung - 01.01.2018 - 01.01.2022
Abgeschlossen
Projektleitung: Sigrist Sarah
Mitarbeiter/innen: Bilz Stefan, Räss Andrea
Defining the identity and differentiation pathways of the immune-stimulating fibroblastic tumor stroma
01.01.2018Lung cancer is the most frequent cause of death in cancer patients in industrialized countries. A particular property of non-small cell lung cancer is the composition of the tumor microenvironment (TME) with a very high proportion of stromal cells. W...
Grundlagenforschung - 01.01.2018 - 31.12.2021
Automatisch geschlossen
Projektleitung: Ludewig Burkhard
Mitarbeiter/innen: De Martin Angelina
I6T-MC-AMAN
01.01.2018A Phase 3, Multicenter, Randomized, Double-Blind, Parallel, Placebo-Controlled Induction Study of Mirikizumab in Conventional-Failed and Biologic-Failed Patients with Moderately to Severely Active Ulcerative Colitis LUCENT 1
Klinische Forschung - 01.01.2018 - 01.02.2021
Abgeschlossen
Projektleitung: Brand Stephan
Mitarbeiter/innen: Krieger-Grübel Claudia, Sulz Michael, Smolders Jolijn
I6T-MC-AMBG
01.01.2018A Phase 3, Multicenter, Randomized, Double-Blind, Parallel-Arm, Placebo-Controlled Maintenance Study of Mirikizumab in Patients with Moderately to Severely Active Ulcerative Colitis LUCENT 2
Klinische Forschung - 01.01.2018 - 01.06.2021
Automatisch geschlossen
Projektleitung: Brand Stephan
Mitarbeiter/innen: Sulz Michael, Krieger-Grübel Claudia, Smolders Jolijn
ACRE
01.01.2018A MULTICENTER, MULTI-NATIONAL, RANDOMISED, DOUBLE-BLIND, PLACEBO CONTROLLED, PARALLEL GROUP, PHASE IIA STUDY TO EVALUATE THE EFFICACY, SAFETY AND TOLERABILITY OF AN ANTHOCYANIN RICH EXTRACT (ACRE) IN PATIENTS WITH ULCERATIVE COLITIS.
Klinische Forschung - 01.01.2018 - 01.07.2021
Abgeschlossen
Projektleitung: Brand Stephan
Mitarbeiter/innen: Stillhard Roman, Sulz Michael, Krieger-Grübel Claudia, Smolders Jolijn
PIONEER 7
08.12.2017Eine Studie zur Untersuchung der Wirksamkeit und Sicherheit von oralem Semaglutid unter Verwendung einer flexiblen Dosisanpassung bei Patienten mit Typ 2 Diabetes Mellitus im Vergleich zu Sitagliptin
Klinische Forschung - 08.12.2017 - 31.07.2019
Abgeschlossen
Projektleitung: Bilz Stefan
Mitarbeiter/innen: Drescher Tilman, Räss Andrea
Lilly RHCF SPIRIT
16.10.2017A 52-Week Multicenter, Randomized, Open-Label, Parallel- Group Study Evaluating the Efficacy and Safety of Ixekizumab versus Adalimumab in Patients with Psoriatic Arthritis Who Are Biologic Disease-Modifying Anti-Rheumatic Drug Naive
Klinische Forschung - 16.10.2017 - 24.10.2021
Abgeschlossen
Projektleitung: Rubbert-Roth Andrea
Mitarbeiter/innen: Bartz-Batliner Mira, Forrer Silvia, Hutz Carina Liane, Neumann Thomas
A Phase 2, multi-center, open label study of NIR178 in combination with PDR001 in patients with selected ad-vanced solid tumors and non-Hodgkin lymphoma
05.10.2017This is a multi-center, open label, phase 2 study to evaluate efficacy of the NIR178 and PDR001 combination in NSCLC, other solid tumors, and diffuse large B-cell lymphoma (DLBCL). The study has three parts: part 1: Multi-arm Bayesian adaptive signal...
Klinische Forschung - 05.10.2017 - 20.02.2024
Automatisch geschlossen
Projektleitung: Jörger Markus
Anal Mapping Biopsies for Human Papilloma Virus (HPV) Associated Lesions
04.10.2017Es gibt keinen eindeutigen Goldstandard für die Diagnose von HPV-assoziierten Analläsionen. Die übliche Diagnostik erfolgt mittels hochauflösender Anoskopie (HRA). Die diagnostische Genauigkeit dieser Methode ist jedoch unklar und stark vom Prüfer ab...
Klinische Forschung - 04.10.2017 - 04.02.2018
Abgeschlossen
Projektleitung: Baumeler Stephan, Borovicka Jan, Marti Lukas
Mitarbeiter/innen: Maurus Christine
Abbvie M15-572 Phase 3 PsA mit inadäquater Response auf bDMARD
02.10.2017A Phase 3, Randomized, Double-Blind, Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Subjects with Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Non-Biologic Disease Modifying Anti-Rheumat...
Klinische Forschung - 02.10.2017 - 03.10.2024
Automatisch geschlossen
Projektleitung: Rubbert-Roth Andrea
Mitarbeiter/innen: Bartz-Batliner Mira, Hutz Carina Liane, Neumann Thomas
SERVE - Effect of phosphodiesterase-5 inhibition with Tadalafil on SystEmic Right VEntricular size and function
01.10.2017This study assesses in a pilot trial the effect of PDE-5 inhibition with Tadalafil on RV size and function, exercise capacity and neurohumoral activation in adults with a systemic RV over a 3-year follow-up period. Included patients: Adults (≥18 year...
Klinische Forschung - 01.10.2017 - 01.07.2021
Abgeschlossen
Projektleitung: Engel Reto
Mitarbeiter/innen: Gemperle Michaela
Azithromycin for the treatment of cough in idiopathic pulmonary fibrosis
01.10.2017Multi centre, prospective, randomized, double blind, 2 treatment, 2 period crossover study with two 12-week treatment periods separated by a 4 week drug-free washout period and a 4 week follow-up performed at the University Hospital Berne, Basel, Zür...
Klinische Forschung - 01.10.2017 - 01.12.2018
Automatisch geschlossen
Projektleitung: Brutsche Martin
Mitarbeiter/innen: Finger Rebekka, Tschirren Ursina, Baty Florent, Widmer Sandra