Dr. med. et phil. nat. David Semela
Leitender Arzt Hepatologie
Forschungsgruppenleiter Liver Biology Lab, Departement Biomedizin, Universitätsspital Basel
Leitende(r) Arzt/Ärztin
Gastroenterologie | Hepatologie · Dept. I
Assessment of hepatic steatosis by controlled attenuation parameter using the M and XL probes: an individual patient data meta-analysis
Petroff D, Sheridan D, Cobbold J, Naveau S, Lupsor-Platon M, Mueller S, Krag A, Irles-Depe M, Semela D, Wong G, Wong V, Villela-Nogueira C, Garg H, Chazouillères O, Wiegand J, Anstee Q, Tsochatzis E, Blank V, Newsome P, Shalimar, Voican C, Thiele M, de Lédinghen V, Baumeler S, Chan W, Perlemuter G, Cardoso A, Aggarwal S, Sasso M, Eddowes P, Allison M, Karlas T. Assessment of hepatic steatosis by controlled attenuation parameter using the M and XL probes: an individual patient data meta-analysis. Lancet Gastroenterol Hepatol 2021; 6:185-198.
16.01.2021Assessment of hepatic steatosis by controlled attenuation parameter using the M and XL probes: an individual patient data meta-analysis
16.01.2021Lancet Gastroenterol Hepatol 2021; 6:185-198
Petroff David, Sheridan David, Cobbold Jeremy F, Naveau Sylvie, Lupsor-Platon Monica, Mueller Sebastian, Krag Aleksander, Irles-Depe Marie, Semela David, Wong Grace Lai-Hung, Wong Vincent Wai-Sun, Villela-Nogueira Cristiane A, Garg Harshit, Chazouillères Olivier, Wiegand Johannes, Anstee Quentin M, Tsochatzis Emmanuel, Blank Valentin, Newsome Philip N, Shalimar, Voican Cosmin Sebastian, Thiele Maja, de Lédinghen Victor, Baumeler Stephan, Chan Wah Kheong, Perlemuter Gabriel, Cardoso Ana-Carolina, Aggarwal Sandeep, Sasso Magali, Eddowes Peter J, Allison Michael, Karlas Thomas
Hepatozelluläres Karzinom: Paradigmenwechsel in der Systemtherapie
Meyer-Herbon P, Muellhaupt B, Semela D. Hepatozelluläres Karzinom: Paradigmenwechsel in der Systemtherapie. Swiss Med Forum 2021; 21
01.01.2021Hepatozelluläres Karzinom: Paradigmenwechsel in der Systemtherapie
01.01.2021Swiss Med Forum 2021; 21
Meyer-Herbon Pamela, Muellhaupt B, Semela David
Primary biliary cholangitis with normal alkaline phosphatase: A neglected clinical entity challenging current guidelines
Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D, Costantini S, Cerny A, Messina P, Di Bartolomeo C, Merlo E, Kolbus N, Voreck A, Mazzucchelli L, Zen Y, Semela D, Mertens J, Stirnimann G, Swiss PBC Cohort Study Group. Primary biliary cholangitis with normal alkaline phosphatase: A neglected clinical entity challenging current guidelines. J Autoimmun 2020; 116:102578.
20.11.2020Primary biliary cholangitis with normal alkaline phosphatase: A neglected clinical entity challenging current guidelines
20.11.2020J Autoimmun 2020; 116:102578
Terziroli Beretta-Piccoli Benedetta, Mieli-Vergani Giorgina, Vergani Diego, Costantini Silvia, Cerny Andreas, Messina Paola, Di Bartolomeo Claudia, Merlo Elisabetta, Kolbus Norbert, Voreck Anja, Mazzucchelli Luca, Zen Yoh, Semela David, Mertens Joachim, Stirnimann Guido, Swiss PBC Cohort Study Group
A prospective, multicenter, post-marketing observational study to measure the quality of life of HCV genotype 1 infected, treatment naïve patients suffering from fatigue and receiving 3D regimen: The HEMATITE study
Semmo N, Mullhaupt B, Ruckstuhl L, Magenta L, Clerc O, Torgler R, Semela D. A prospective, multicenter, post-marketing observational study to measure the quality of life of HCV genotype 1 infected, treatment naïve patients suffering from fatigue and receiving 3D regimen: The HEMATITE study. PloS one 2020; 15:e0241267.
04.11.2020A prospective, multicenter, post-marketing observational study to measure the quality of life of HCV genotype 1 infected, treatment naïve patients suffering from fatigue and receiving 3D regimen: The HEMATITE study
04.11.2020PloS one 2020; 15:e0241267
Semmo Nasser, Mullhaupt Beat, Ruckstuhl Lisa, Magenta Lorenzo, Clerc Olivier, Torgler Ralph, Semela David
Contrast-enhanced ultrasound can guide the therapeutic strategy by improving the detection of colorectal liver metastases
Sawatzki M, Guller U, Güsewell S, Husarik D, Semela D, Brand S. Contrast-enhanced ultrasound can guide the therapeutic strategy by improving the detection of colorectal liver metastases. Journal of hepatology 2020; online
13.10.2020Contrast-enhanced ultrasound can guide the therapeutic strategy by improving the detection of colorectal liver metastases
13.10.2020Journal of hepatology 2020; online
Sawatzki Mikael, Guller Ulrich, Güsewell Sabine, Husarik Daniela, Semela David, Brand Stephan
Extrahepatic autoimmune diseases in primary biliary cholangitis: Prevalence and significance for clinical presentation and disease outcome
Efe C, Nilsson E, Heurgué-Berlot A, Demir N, Semela D, Kiyici M, Schiano T, Montano-Loza A, Berg T, Ozaslan E, Yoshida E, Bonder A, Marschall H, Beretta-Piccoli B, Önnerhag K, Rorsman F, Torgutalp M, Henriksson I, Alalkim F, Lytvyak E, Trivedi H, Eren F, Fischer J, Chayanupatkul M, Coppo C, Purnak T, Muratori L, Werner M, Muratori P, Wahlin S. Extrahepatic autoimmune diseases in primary biliary cholangitis: Prevalence and significance for clinical presentation and disease outcome. J Gastroenterol Hepatol 2020
13.08.2020Extrahepatic autoimmune diseases in primary biliary cholangitis: Prevalence and significance for clinical presentation and disease outcome
13.08.2020J Gastroenterol Hepatol 2020
Efe Cumali, Nilsson Emma, Heurgué-Berlot Alexandra, Demir Nurhan, Semela David, Kiyici Murat, Schiano Thomas D, Montano-Loza Aldo J, Berg Thomas, Ozaslan Ersan, Yoshida Eric M, Bonder Alan, Marschall Hanns-Ulrich, Beretta-Piccoli Benedetta Terziroli, Önnerhag Kristina, Rorsman Fredrik, Torgutalp Murat, Henriksson Ida, Alalkim Fatema, Lytvyak Ellina, Trivedi Hirsh, Eren Fatih, Fischer Janett, Chayanupatkul Maneerat, Coppo Claudia, Purnak Tugrul, Muratori Luigi, Werner Mårten, Muratori Paolo, Wahlin Staffan
All-Cause Mortality and Causes of Death in the Swiss Hepatitis C Cohort Study (SCCS)
Roelens M, Keiser O, Negro F, Junker C, Semela D, Clerc O, Mullhaupt B, Schmid P, Semmo N, Cerny A, Moradpour D, Bertisch B, Swiss Hepatitis C Cohort Study. All-Cause Mortality and Causes of Death in the Swiss Hepatitis C Cohort Study (SCCS). Open Forum Infect Dis 2020; 7:ofaa308.
25.07.2020All-Cause Mortality and Causes of Death in the Swiss Hepatitis C Cohort Study (SCCS)
25.07.2020Open Forum Infect Dis 2020; 7:ofaa308
Roelens Maroussia, Keiser Olivia, Negro Francesco, Junker Christoph, Semela David, Clerc Olivier, Mullhaupt Beat, Schmid Patrick, Semmo Nasser, Cerny Andreas, Moradpour Darius, Bertisch Barbara, Swiss Hepatitis C Cohort Study
Nonalcoholic fatty liver disease burden - Switzerland 2018-2030
Goossens N, Semela D, Razavi H, Negro F, Muellhaupt B, Moriggia A, Mertens J, Jornayvaz F, Dufour J, Cerny A, Bellentani S, Estes C. Nonalcoholic fatty liver disease burden - Switzerland 2018-2030. Swiss Med Wkly 2019; 149:w20152.
17.12.2019Nonalcoholic fatty liver disease burden - Switzerland 2018-2030
17.12.2019Swiss Med Wkly 2019; 149:w20152
Goossens Nicolas, Semela David, Razavi Homie, Negro Francesco, Muellhaupt Beat, Moriggia Alberto, Mertens Joachim, Jornayvaz François R, Dufour Jean-François, Cerny Andreas, Bellentani Stefano, Estes Chris
Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis
Brenig R, Antoniades C, Wendon J, Heim M, Ludewig B, Weston C, Duong F, Semela D, Brand S, Boldanova T, Künzler-Heule P, Cupovic J, Besse L, Pérez Shibayama C, Singanayagam A, Geng A, Triantafyllou E, Pop O, Bernsmeier C. Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis. Life Sci Alliance 2019; 3
10.12.2019Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis
10.12.2019Life Sci Alliance 2019; 3
Brenig Robert, Antoniades Charalambos G, Wendon Julia, Heim Markus H, Ludewig Burkhard, Weston Christopher J, Duong François Ht, Semela David, Brand Stephan, Boldanova Tuyana, Künzler-Heule Patrizia, Cupovic Jovana, Besse Lenka, Pérez Shibayama Christian Ivan, Singanayagam Arjuna, Geng Anne, Triantafyllou Evangelos, Pop Oltin, Bernsmeier Christine
Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1-3 Infections
Dietz J, Backhus J, Zizer E, Boettler T, Neumann-Haefelin C, Semela D, Stauber R, Berg T, Berg C, Zeuzem S, Vermehren J, Sarrazin C, Buggisch P, Matschenz K, Spengler U, Mullhaupt B, Schulze Zur Wiesch J, Piecha F, Mauss S, Seegers B, Hinrichsen H, Antoni C, Wietzke-Braun P, Peiffer K, Berger A, European HCV Resistance Study Group. Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1-3 Infections. Clin Gastroenterol Hepatol 2019
06.11.2019Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1-3 Infections
06.11.2019Clin Gastroenterol Hepatol 2019
Dietz Julia, Backhus Johanna, Zizer Eugen, Boettler Tobias, Neumann-Haefelin Christoph, Semela David, Stauber Rudolf, Berg Thomas, Berg Christoph, Zeuzem Stefan, Vermehren Johannes, Sarrazin Christoph, Buggisch Peter, Matschenz Katrin, Spengler Ulrich, Mullhaupt Beat, Schulze Zur Wiesch Julian, Piecha Felix, Mauss Stefan, Seegers Barbara, Hinrichsen Holger, Antoni Christoph, Wietzke-Braun Perdita, Peiffer Kai-Henrik, Berger Annemarie, European HCV Resistance Study Group
Identification of an Endoglin Variant Associated With HCV-Related Liver Fibrosis Progression by Next-Generation Sequencing
About F, Casanova J, Theodorou I, Sultanik P, Poynard T, Pol S, Bochud P, Cobat A, Abel L, Swiss Hepatitis C Cohort Study Group, Semmo N, Semela D, Bibert S, Jouanguy E, Nalpas B, Lorenzo L, Rattina V, Zarhrate M, Hanein S, Munteanu M, Mullhaupt B, French ANRS HC EP 26 Genoscan Study Group. Identification of an Endoglin Variant Associated With HCV-Related Liver Fibrosis Progression by Next-Generation Sequencing. Front Genet 2019; 10:1024.
04.11.2019Identification of an Endoglin Variant Associated With HCV-Related Liver Fibrosis Progression by Next-Generation Sequencing
04.11.2019Front Genet 2019; 10:1024
About Frédégonde, Casanova Jean-Laurent, Theodorou Ioannis, Sultanik Philippe, Poynard Thierry, Pol Stanislas, Bochud Pierre-Yves, Cobat Aurélie, Abel Laurent, Swiss Hepatitis C Cohort Study Group, Semmo Nasser, Semela David, Bibert Stéphanie, Jouanguy Emmanuelle, Nalpas Bertrand, Lorenzo Lazaro, Rattina Vimel, Zarhrate Mohammed, Hanein Sylvain, Munteanu Mona, Mullhaupt Beat, French ANRS HC EP 26 Genoscan Study Group
Validation of Risk Scoring Systems in Ursodeoxycholic Acid-Treated Patients With Primary Biliary Cholangitis
Efe C, Günşar F, Nilsson E, Heurgué-Berlot A, Güzelbulut F, Demir N, Gönen C, Semela D, Aladağ M, Kiyici M, Schiano T, Montano-Loza A, Berg T, Ozaslan E, Yoshida E, Bonder A, Marschall H, Önnerhag K, Rorsman F, Muratori P, Taşçilar K, Henriksson I, Lytvyak E, Alalkim F, Trivedi H, Eren F, Eliasson J, Beretta-Piccoli B, Fischer J, Calişkan A, Chayanupatkul M, Coppo C, Ytting H, Purnak T, Muratori L, Werner M, Wahlin S. Validation of Risk Scoring Systems in Ursodeoxycholic Acid-Treated Patients With Primary Biliary Cholangitis. Am J Gastroenterol 2019; 114:1101-1108.
01.07.2019Validation of Risk Scoring Systems in Ursodeoxycholic Acid-Treated Patients With Primary Biliary Cholangitis
01.07.2019Am J Gastroenterol 2019; 114:1101-1108
Efe Cumali, Günşar Fulya, Nilsson Emma, Heurgué-Berlot Alexandra, Güzelbulut Fatih, Demir Nurhan, Gönen Can, Semela David, Aladağ Murat, Kiyici Murat, Schiano Thomas D, Montano-Loza Aldo J, Berg Thomas, Ozaslan Ersan, Yoshida Eric M, Bonder Alan, Marschall Hanns-Ulrich, Önnerhag Kristina, Rorsman Fredrik, Muratori Paolo, Taşçilar Koray, Henriksson Ida, Lytvyak Ellina, Alalkim Fatema, Trivedi Hirsh, Eren Fatih, Eliasson Johanna, Beretta-Piccoli Benedetta Terziroli, Fischer Janett, Calişkan Ali Riza, Chayanupatkul Maneerat, Coppo Claudia, Ytting Henriette, Purnak Tugrul, Muratori Luigi, Werner Mårten, Wahlin Staffan
Contrast-enhanced ultrasound (CEUS) has excellent diagnostic accuracy in differentiating focal liver lesions: results from a Swiss tertiary gastroenterological centre
Sawatzki M, Meyenberger C, Brand S, Semela D. Contrast-enhanced ultrasound (CEUS) has excellent diagnostic accuracy in differentiating focal liver lesions: results from a Swiss tertiary gastroenterological centre. Swiss Med Wkly 2019; 149:w20087.
30.06.2019Contrast-enhanced ultrasound (CEUS) has excellent diagnostic accuracy in differentiating focal liver lesions: results from a Swiss tertiary gastroenterological centre
30.06.2019Swiss Med Wkly 2019; 149:w20087
Sawatzki Mikael, Meyenberger Christa, Brand Stephan, Semela David
Impact of geographic origin on access to therapy and therapy outcomes in the Swiss Hepatitis C Cohort Study
Brezzi M, Keiser O, Negro F, Semela D, Mullhaupt B, Semmo N, Terziroli Beretta-Piccoli B, Moradpour D, Roelens M, Bertisch B, Swiss Hepatitis C Cohort Study. Impact of geographic origin on access to therapy and therapy outcomes in the Swiss Hepatitis C Cohort Study. PloS one 2019; 14:e0218706.
24.06.2019Impact of geographic origin on access to therapy and therapy outcomes in the Swiss Hepatitis C Cohort Study
24.06.2019PloS one 2019; 14:e0218706
Brezzi Matteo, Keiser Olivia, Negro Francesco, Semela David, Mullhaupt Beat, Semmo Nasser, Terziroli Beretta-Piccoli Benedetta, Moradpour Darius, Roelens Maroussia, Bertisch Barbara, Swiss Hepatitis C Cohort Study
Porto-sinusoidal vascular disease: proposal and description of a novel entity
De Gottardi A, Berzigotti A, Bioulac-Sage P, Primignani M, Semela D, Elkrief L, Bedossa P, Valla D, Garcia-Pagan J, Plessier A, Nery F, Rautou P, Schouten J, Rubbia-Brandt L, Leebeek F, Trebicka J, Murad S, Vilgrain V, Hernandez-Gea V, VALDIG group. Porto-sinusoidal vascular disease: proposal and description of a novel entity. Lancet Gastroenterol Hepatol 2019; 4:399-411.
01.05.2019Porto-sinusoidal vascular disease: proposal and description of a novel entity
01.05.2019Lancet Gastroenterol Hepatol 2019; 4:399-411
De Gottardi Andrea, Berzigotti Annalisa, Bioulac-Sage Paulette, Primignani Massimo, Semela David, Elkrief Laure, Bedossa Pierre, Valla Dominique, Garcia-Pagan Juan Carlos, Plessier Aurélie, Nery Filipe, Rautou Pierre-Emmanuel, Schouten Jeoffrey, Rubbia-Brandt Laura, Leebeek Frank, Trebicka Jonel, Murad Sarwa Darwish, Vilgrain Valérie, Hernandez-Gea Virginia, VALDIG group
Autoimmune liver serology before and after successful treatment of chronic hepatitis C by direct acting antiviral agents
Terziroli Beretta-Piccoli B, Muratori L, Vergani D, Mieli-Vergani G, Moradpour D, Semela D, Semmo N, Mertens J, Cerny A, Melidona L, Tesei C, Silvestri T, Grondona A, Deleonardi G, Di Bartolomeo C, Swiss Hepatitis C Cohort Study. Autoimmune liver serology before and after successful treatment of chronic hepatitis C by direct acting antiviral agents. J Autoimmun 2019; 102:89-95.
30.04.2019Autoimmune liver serology before and after successful treatment of chronic hepatitis C by direct acting antiviral agents
30.04.2019J Autoimmun 2019; 102:89-95
Terziroli Beretta-Piccoli Benedetta, Muratori Luigi, Vergani Diego, Mieli-Vergani Giorgina, Moradpour Darius, Semela David, Semmo Nasser, Mertens Joachim, Cerny Andreas, Melidona Laura, Tesei Cinzia, Silvestri Tania, Grondona Ana Gabriela, Deleonardi Gaia, Di Bartolomeo Claudia, Swiss Hepatitis C Cohort Study
Controlled attenuation parameter for the assessment of liver steatosis in comparison with liver histology: a single-centre real life experience
Baumeler S, Jochum W, Neuweiler J, Bergamin I, Semela D. Controlled attenuation parameter for the assessment of liver steatosis in comparison with liver histology: a single-centre real life experience. Swiss Med Wkly 2019; 149:w20077.
26.04.2019Controlled attenuation parameter for the assessment of liver steatosis in comparison with liver histology: a single-centre real life experience
26.04.2019Swiss Med Wkly 2019; 149:w20077
Baumeler Stephan, Jochum Wolfram, Neuweiler Jörg, Bergamin Irina, Semela David
SDF-1/CXCR4 signalling is involved in blood vessel growth and remodelling by intussusception
Dimova I, Karthik S, Makanya A, Hlushchuk R, Semela D, Volarevic V, Djonov V. SDF-1/CXCR4 signalling is involved in blood vessel growth and remodelling by intussusception. J Cell Mol Med 2019; 23:3916-3926.
04.04.2019SDF-1/CXCR4 signalling is involved in blood vessel growth and remodelling by intussusception
04.04.2019J Cell Mol Med 2019; 23:3916-3926
Dimova Ivanka, Karthik Swapna, Makanya Andrew, Hlushchuk Ruslan, Semela David, Volarevic Vladislav, Djonov Valentin
Microelimination of chronic hepatitis C in Switzerland: modelling the Swiss Hepatitis Strategy goals in eastern, western and northern regions
Rusch U, Robbins S, Razavi H, Vernazza P, Blach S, Bruggmann P, Mullhaupt B, Negro F, Semela D. Microelimination of chronic hepatitis C in Switzerland: modelling the Swiss Hepatitis Strategy goals in eastern, western and northern regions. Swiss Med Wkly 2019; 149:w14694.
23.01.2019Microelimination of chronic hepatitis C in Switzerland: modelling the Swiss Hepatitis Strategy goals in eastern, western and northern regions
23.01.2019Swiss Med Wkly 2019; 149:w14694
Rusch Urs, Robbins Sarah, Razavi Homie, Vernazza Pietro, Blach Sarah, Bruggmann Philip, Mullhaupt Beat, Negro Francesco, Semela David
Progress toward implementing the Swiss Hepatitis Strategy: Is HCV elimination possible by 2030?
Mullhaupt B, Bruggmann P, Bihl F, Blach S, Lavanchy D, Razavi H, Robbins Scott S, Semela D, Negro F. Progress toward implementing the Swiss Hepatitis Strategy: Is HCV elimination possible by 2030?. PloS one 2018; 13:e0209374.
31.12.2018Progress toward implementing the Swiss Hepatitis Strategy: Is HCV elimination possible by 2030?
31.12.2018PloS one 2018; 13:e0209374
Mullhaupt Beat, Bruggmann Philip, Bihl Florian, Blach Sarah, Lavanchy Daniel, Razavi Homie, Robbins Scott Sarah, Semela David, Negro Francesco