Unit
Medizinisches Forschungszentrum
MFZ · Management
Conserved stromal-immune cell circuits secure B cell homeostasis and function.
Lütge M, De Martin A, Gil Cruz C, Pérez Shibayama C, Stanossek Y, Onder L, Cheng H, Kurz L, Cadosch N, Soneson C, Robinson M, Stöckli S, Ludewig B, Pikor N. Conserved stromal-immune cell circuits secure B cell homeostasis and function. Nat Immunol 2023
May 18, 2023Conserved stromal-immune cell circuits secure B cell homeostasis and function.
May 18, 2023Nat Immunol 2023
Lütge Mechthild, De Martin Angelina, Gil Cruz Cristina, Pérez Shibayama Christian Ivan, Stanossek Yves, Onder Lucas, Cheng Hung-Wei, Kurz Lisa, Cadosch Nadine, Soneson Charlotte, Robinson Mark D, Stöckli Sandro, Ludewig Burkhard, Pikor Natalia
PI16 reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches.
De Martin A, Stanossek Y, Lütge M, Cadosch N, Onder L, Cheng H, Brandstadter J, Maillard I, Stöckli S, Pikor N, Ludewig B. PI16 reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches. Nat Immunol 2023; 24:1138-1148.
May 18, 2023PI16 reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches.
May 18, 2023Nat Immunol 2023; 24:1138-1148
De Martin Angelina, Stanossek Yves, Lütge Mechthild, Cadosch Nadine, Onder Lucas, Cheng Hung-Wei, Brandstadter Joshua D, Maillard Ivan, Stöckli Sandro, Pikor Natalia, Ludewig Burkhard
A case of Malaria tertiana caused by Plasmodium vivax – an example of how climate change is affecting the outbreak of infectious diseases
Payne E, Doenecke C, Haller S (2023). A case of Malaria tertiana caused by Plasmodium vivax – an example of how climate change is affecting the outbreak of infectious diseases.
May 10, 2023A case of Malaria tertiana caused by Plasmodium vivax – an example of how climate change is affecting the outbreak of infectious diseases
May 10, 2023SGAIM 7th spring congress
Payne Emily, Doenecke Christian, Haller Sabine
Pseudorabies virus hijacks DDX3X, initiating an addictive "mad itch" and immune suppression, to facilitate viral spread.
Cronin S, Tejada M, Song R, Laval K, Cikes D, Ji M, Brai A, Stadlmann J, Novatchikova M, Perlot T, Hasan A, Botta L, Decker T, Lazovic J, Hagelkruys A, Enquist L, Rao S, Koyuncu O, Penninger J. Pseudorabies virus hijacks DDX3X, initiating an addictive "mad itch" and immune suppression, to facilitate viral spread. bioRxiv 2023
May 9, 2023Pseudorabies virus hijacks DDX3X, initiating an addictive "mad itch" and immune suppression, to facilitate viral spread.
May 9, 2023bioRxiv 2023
Cronin Shane J F, Tejada Miguel A, Song Ren, Laval Kathlyn, Cikes Domagoj, Ji Ming, Brai Annalaura, Stadlmann Johannes, Novatchikova Maria, Perlot Thomas, Hasan Ali, Botta Lorenzo, Decker Thomas, Lazovic Jelena, Hagelkruys Astrid, Enquist Lynn, Rao Shuan, Koyuncu Orkide O, Penninger Josef M
Prospective Evaluation of Magnetic Resonance Imaging Features of Magnesium-Based Alloy Screw Resorption in Pediatric Fractures.
Wälti S, Wildermuth S, Willems E, Fischer T, Dietrich T, Leschka S, Matissek C, Krebs T, Markart S. Prospective Evaluation of Magnetic Resonance Imaging Features of Magnesium-Based Alloy Screw Resorption in Pediatric Fractures. J Clin Med 2023; 12
Apr 21, 2023Prospective Evaluation of Magnetic Resonance Imaging Features of Magnesium-Based Alloy Screw Resorption in Pediatric Fractures.
Apr 21, 2023J Clin Med 2023; 12
Wälti Stephan, Wildermuth Simon, Willems Erik, Fischer Tim, Dietrich Tobias, Leschka Sebastian, Matissek Christoph, Krebs Thomas, Markart Stefan
COVID-19 burden and influencing factors in Swiss long-term-care facilities: a cross-sectional analysis of a multicentre observational cohort.
Scanferla G, Héquet D, Graf N, Münzer T, Kessler S, Kohler P, Nussbaumer A, Petignat C, Schlegel M, Flury D. COVID-19 burden and influencing factors in Swiss long-term-care facilities: a cross-sectional analysis of a multicentre observational cohort. Swiss Med Wkly 2023; 153:40052.
Mar 31, 2023COVID-19 burden and influencing factors in Swiss long-term-care facilities: a cross-sectional analysis of a multicentre observational cohort.
Mar 31, 2023Swiss Med Wkly 2023; 153:40052
Scanferla Giulia, Héquet Delphine, Graf Nicole, Münzer Thomas, Kessler Simone, Kohler Philipp, Nussbaumer Andres, Petignat Christiane, Schlegel Matthias, Flury Domenica
An Innate Checkpoint Determines Immune Dysregulation and Immunopathology during Pulmonary Murine Coronavirus Infection.
Grabherr S, Waltenspühl A, Büchler L, Lütge M, Cheng H, Caviezel-Firner S, Ludewig B, Krebs P, Pikor N. An Innate Checkpoint Determines Immune Dysregulation and Immunopathology during Pulmonary Murine Coronavirus Infection. J Immunol 2023; 210:774-785.
Mar 15, 2023An Innate Checkpoint Determines Immune Dysregulation and Immunopathology during Pulmonary Murine Coronavirus Infection.
Mar 15, 2023J Immunol 2023; 210:774-785
Grabherr Sarah, Waltenspühl Alexandra, Büchler Lorina, Lütge Mechthild, Cheng Hung-Wei, Caviezel-Firner Sonja, Ludewig Burkhard, Krebs Philippe, Pikor Natalia
Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs.
Loo L, Waller M, Moreno C, Cole A, Stella A, Pop O, Jochum A, Ali O, Denes C, Hamoudi Z, Chung F, Aggarwal A, Low J, Patel K, Siddiquee R, Kang T, Mathivanan S, Mackay J, Jochum W, Flatz L, Hesselson D, Turville S, Neely G. Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs. PLoS Biol 2023; 21:e3001967.
Feb 9, 2023Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs.
Feb 9, 2023PLoS Biol 2023; 21:e3001967
Loo Lipin, Waller Matthew A, Moreno Cesar L, Cole Alexander J, Stella Alberto Ospina, Pop Oltin-Tiberiu, Jochum Ann-Kristin, Ali Omar Hasan, Denes Christopher E, Hamoudi Zina, Chung Felicity, Aggarwal Anupriya, Low Jason K K, Patel Karishma, Siddiquee Rezwan, Kang Taeyoung, Mathivanan Suresh, Mackay Joel P, Jochum Wolfram, Flatz Lukas, Hesselson Daniel, Turville Stuart G, Neely G Gregory
A novel cryopreservation and biobanking strategy to study lymphoid tissue stromal cells in human disease.
Brandstadter J, De Martin A, Lütge M, Ferreira A, Gaudette B, Stanossek Y, Wang S, Gonzalez M, Camiolo E, Wertheim G, Austin B, Allman D, Salim M, Fajgenbaum D, Aster J, Ludewig B, Maillard I. A novel cryopreservation and biobanking strategy to study lymphoid tissue stromal cells in human disease. bioRxiv 2023
Feb 7, 2023A novel cryopreservation and biobanking strategy to study lymphoid tissue stromal cells in human disease.
Feb 7, 2023bioRxiv 2023
Brandstadter Joshua D, De Martin Angelina, Lütge Mechthild, Ferreira Antonio, Gaudette Brian T, Stanossek Yves, Wang Shumei, Gonzalez Michael V, Camiolo Edward, Wertheim Gerald, Austin Bridget, Allman David, Salim M, Fajgenbaum David C, Aster Jon C, Ludewig Burkhard, Maillard Ivan
Myocardial Milieu Favors Local Differentiation of Regulatory T Cells.
Delgobo M, Weiß E, Ashour D, Richter L, Popiolkowski L, Arampatzi P, Stangl V, Arias-Loza P, Mariotti-Ferrandiz E, Rainer P, Saliba A, Ludewig B, Hofmann U, Frantz S, Ramos G. Myocardial Milieu Favors Local Differentiation of Regulatory T Cells. Circ Res 2023; 132:565-582.
Feb 6, 2023Myocardial Milieu Favors Local Differentiation of Regulatory T Cells.
Feb 6, 2023Circ Res 2023; 132:565-582
Delgobo Murilo, Weiß Emil, Ashour DiyaaElDin, Richter Leon, Popiolkowski Lisa, Arampatzi Panagiota, Stangl Verena, Arias-Loza Paula, Mariotti-Ferrandiz Encarnita, Rainer Peter P, Saliba Antoine-Emmanuel, Ludewig Burkhard, Hofmann Ulrich G, Frantz Stefan, Ramos Gustavo Campos
Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial.
Mohebbi N, Ritter A, Wiegand A, Graf N, Dahdal S, Sidler D, Arampatzis S, Hadaya K, Müller T, Wagner C, Wüthrich R. Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial. Lancet 2023; 401:557-567.
Jan 25, 2023Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial.
Jan 25, 2023Lancet 2023; 401:557-567
Mohebbi Nilufar, Ritter Alexander, Wiegand Anna, Graf Nicole, Dahdal Suzan, Sidler Daniel, Arampatzis Spyridon, Hadaya Karine, Müller Thomas F, Wagner Carsten A, Wüthrich Rudolf P
Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19.
Sinnberg T, Lichtensteiger C, Ali O, Pop O, Risch L, Brugger S, Velic A, Bomze D, Kohler P, Vernazza P, Albrich W, Kahlert C, Abdou M, Wyss N, Hofmeister K, Niessner H, Zinner C, Gilardi M, Tzankov A, Röcken M, Dulovic A, Shambat S, Ruetalo N, Buehler P, Scheier T, Jochum W, Kern L, Henz S, Schneider T, Kuster G, Lampart M, Siegemund M, Bingisser R, Schindler M, Schneiderhan-Marra N, Kalbacher H, McCoy K, Spengler W, Brutsche M, Macek B, Twerenbold R, Penninger J, Matter M, Flatz L, Jochum A. Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19. Am J Respir Crit Care Med 2023; 207:38-49.
Jan 1, 2023Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19.
Jan 1, 2023Am J Respir Crit Care Med 2023; 207:38-49
Sinnberg Tobias, Lichtensteiger Christa, Ali Omar Hasan, Pop Oltin T, Risch Lorenz, Brugger Silvio D, Velic Ana, Bomze David, Kohler Philipp, Vernazza Pietro, Albrich Werner, Kahlert Christian, Abdou Marie-Therese, Wyss Nina, Hofmeister Kathrin, Niessner Heike, Zinner Carl, Gilardi Mara, Tzankov Alexandar, Röcken Martin, Dulovic Alex, Shambat Srikanth Mairpady, Ruetalo Natalia, Buehler Philipp K, Scheier Thomas C, Jochum Wolfram, Kern Lukas, Henz Samuel, Schneider Tino, Kuster Gabriela M, Lampart Maurin, Siegemund Martin, Bingisser Roland, Schindler Michael, Schneiderhan-Marra Nicole, Kalbacher Hubert, McCoy Kathy D, Spengler Werner, Brutsche Martin H, Macek Boris, Twerenbold Raphael, Penninger Josef M, Matter Matthias S, Flatz Lukas, Jochum Ann-Kristin
Systemic and T cell-associated responses to SARS-CoV-2 immunisation in gut inflammation (STAR SIGN study): effects of biologics on vaccination efficacy of the third dose of mRNA vaccines against SARS-CoV-2.
Woelfel S, Dütschler J, König M, Graf N, Oikonomou V, Krieger-Grübel C, Truniger S, Franke A, Eckhold A, Forsch K, Wyss J, Krupka N, Albrich W, Frei N, Geissler N, Schaub P, STAR SIGN Study Investigators, Friedrich M, Misselwitz B, Korte W, Bürgi J, Brand S. Systemic and T cell-associated responses to SARS-CoV-2 immunisation in gut inflammation (STAR SIGN study): effects of biologics on vaccination efficacy of the third dose of mRNA vaccines against SARS-CoV-2. Aliment Pharmacol Ther 2022; 57:103-116.
Oct 28, 2022Systemic and T cell-associated responses to SARS-CoV-2 immunisation in gut inflammation (STAR SIGN study): effects of biologics on vaccination efficacy of the third dose of mRNA vaccines against SARS-CoV-2.
Oct 28, 2022Aliment Pharmacol Ther 2022; 57:103-116
Woelfel Simon, Dütschler Joel, König Marius, Graf Nicole, Oikonomou Vasileios, Krieger-Grübel Claudia, Truniger Samuel, Franke Annett, Eckhold Annika, Forsch Kristina, Wyss Jacqueline, Krupka Niklas, Albrich Werner, Frei Nicola Fabian, Geissler Nora, Schaub Peter, STAR SIGN Study Investigators, Friedrich Matthias, Misselwitz Benjamin, Korte Wolfgang C, Bürgi Justus J, Brand Stephan
Fibroblastic reticular cells mitigate acute graft-versus-host disease via MHCII-dependent maintenance of regulatory T cells.
Shaikh H, Pezoldt J, Mokhtari Z, Gamboa Vargas J, Le D, Peña Mosca J, Arellano-Viera E, Kern M, Graff C, Beyersdorf N, Lutz M, Riedel A, Büttner-Herold M, Zernecke A, Einsele H, Saliba A, Ludewig B, Huehn J, Beilhack A. Fibroblastic reticular cells mitigate acute graft-versus-host disease via MHCII-dependent maintenance of regulatory T cells. JCI Insight 2022
Oct 13, 2022Fibroblastic reticular cells mitigate acute graft-versus-host disease via MHCII-dependent maintenance of regulatory T cells.
Oct 13, 2022JCI Insight 2022
Shaikh Haroon, Pezoldt Joern, Mokhtari Zeinab, Gamboa Vargas Juan, Le Duc-Dung, Peña Mosca Josefina, Arellano-Viera Estibaliz, Kern Michael Ag, Graff Caroline, Beyersdorf Niklas, Lutz Manfred, Riedel Angela, Büttner-Herold Maike, Zernecke Alma, Einsele Hermann, Saliba Antoine-Emmanuel, Ludewig Burkhard, Huehn Jochen, Beilhack Andreas
Pediatric reference values of anterior visual pathway structures measured with axis-correction on high-resolution 3D T2 fast spin echo sequences.
Markart S, Wildermuth S, Geiss J, Willems E, Sturm V, Ditchfield M, Wälti S. Pediatric reference values of anterior visual pathway structures measured with axis-correction on high-resolution 3D T2 fast spin echo sequences. BMC Pediatr 2022; 22:584.
Oct 8, 2022Pediatric reference values of anterior visual pathway structures measured with axis-correction on high-resolution 3D T2 fast spin echo sequences.
Oct 8, 2022BMC Pediatr 2022; 22:584
Markart Stefan, Wildermuth Simon, Geiss Johannes, Willems Erik, Sturm Veit, Ditchfield Michael, Wälti Stephan
Autoreactive napsin A-specific T cells are enriched in lung tumors and inflammatory lung lesions during immune checkpoint blockade.
Berner F, Bomze D, Lichtensteiger C, Walter V, Niederer R, Hasan Ali O, Wyss N, Bauer J, Freudenmann L, Marcu A, Wolfschmitt E, Haen S, Gross T, Abdou M, Diem S, Knöpfli S, Sinnberg T, Hofmeister K, Cheng H, Toma M, Klümper N, Purde M, Pop O, Jochum A, Pascolo S, Jörger M, Früh M, Jochum W, Rammensee H, Läubli H, Hölzel M, Neefjes J, Walz J, Flatz L. Autoreactive napsin A-specific T cells are enriched in lung tumors and inflammatory lung lesions during immune checkpoint blockade. Sci Immunol 2022; 7:eabn9644.
Sep 2, 2022Autoreactive napsin A-specific T cells are enriched in lung tumors and inflammatory lung lesions during immune checkpoint blockade.
Sep 2, 2022Sci Immunol 2022; 7:eabn9644
Berner Fiamma, Bomze David, Lichtensteiger Christa, Walter Vincent, Niederer Rebekka, Hasan Ali Omar, Wyss Nina, Bauer Jens, Freudenmann Lena Katharina, Marcu Ana, Wolfschmitt Eva-Maria, Haen Sebastian, Gross Thorben, Abdou Marie-Therese, Diem Stefan, Knöpfli Stella, Sinnberg Tobias, Hofmeister Kathrin, Cheng Hung-Wei, Toma Marieta, Klümper Niklas, Purde Mette-Triin, Pop Oltin Tiberiu, Jochum Ann-Kristin, Pascolo Steve, Jörger Markus, Früh Martin, Jochum Wolfram, Rammensee Hans-Georg, Läubli Heinz, Hölzel Michael, Neefjes Jacques, Walz Juliane, Flatz Lukas
In vitro testing of a funnel-tip catheter with different clot types to decrease clot migration in mechanical thrombectomy.
Payne E, Krost-Reuhl S, Heimann A, Keric N, Masomi-Bornwasser J, Gerber T, Seidman L, Kirschner S, Brockmann M, Tanyildizi Y. In vitro testing of a funnel-tip catheter with different clot types to decrease clot migration in mechanical thrombectomy. Interv Neuroradiol 2022; 29:637-647.
Sep 1, 2022In vitro testing of a funnel-tip catheter with different clot types to decrease clot migration in mechanical thrombectomy.
Sep 1, 2022Interv Neuroradiol 2022; 29:637-647
Payne Emily, Krost-Reuhl Samantha, Heimann Axel, Keric Naureen, Masomi-Bornwasser Julia, Gerber Tiemo, Seidman Larissa, Kirschner Stefanie, Brockmann Marc A, Tanyildizi Yasemin
Fibroblasts tune myocardial inflammation and remodeling
Pérez Shibayama C, Gil Cruz C, Ludewig B. Fibroblasts tune myocardial inflammation and remodeling. Nature Cardiovascular Research 2022; 1:694–695.
Aug 12, 2022Fibroblasts tune myocardial inflammation and remodeling
Aug 12, 2022Nature Cardiovascular Research 2022; 1:694–695
Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Ludewig Burkhard
Multitier mechanics control stromal adaptations in the swelling lymph node.
Assen F, Abe J, Hons M, Hauschild R, Shamipour S, Kaufmann W, Costanzo T, Krens G, Brown M, Ludewig B, Hippenmeyer S, Heisenberg C, Weninger W, Hannezo E, Luther S, Stein J, Sixt M. Multitier mechanics control stromal adaptations in the swelling lymph node. Nat Immunol 2022; 23:1246-1255.
Jul 11, 2022Multitier mechanics control stromal adaptations in the swelling lymph node.
Jul 11, 2022Nat Immunol 2022; 23:1246-1255
Assen Frank P, Abe Jun, Hons Miroslav, Hauschild Robert, Shamipour Shayan, Kaufmann Walter A, Costanzo Tommaso, Krens Gabriel, Brown Markus, Ludewig Burkhard, Hippenmeyer Simon, Heisenberg Carl-Philipp, Weninger Wolfgang, Hannezo Edouard, Luther Sanjiv A, Stein Jens V, Sixt Michael
Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naive B cells.
Gómez Atria D, Gaudette B, Londregan J, Kelly S, Perkey E, Allman A, Srivastava B, Koch U, Radtke F, Ludewig B, Siebel C, Ryan R, Robertson T, Burkhardt J, Pear W, Allman D, Maillard I. Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naive B cells. J Clin Invest 2022; 132
Jul 1, 2022Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naive B cells.
Jul 1, 2022J Clin Invest 2022; 132
Gómez Atria Daniela, Gaudette Brian T, Londregan Jennifer, Kelly Samantha, Perkey Eric, Allman Anneka, Srivastava Bhaskar, Koch Ute, Radtke Freddy, Ludewig Burkhard, Siebel Christian W, Ryan Russell Jh, Robertson Tanner F, Burkhardt Janis K, Pear Warren S, Allman David, Maillard Ivan