Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial.
Journal Paper/Review - Jan 25, 2023
Mohebbi Nilufar, Ritter Alexander, Wiegand Anna, Graf Nicole, Dahdal Suzan, Sidler Daniel, Arampatzis Spyridon, Hadaya Karine, Mueller Thomas F, Wagner Carsten A, Wüthrich Rudolf P
Metabolic acidosis is common in kidney transplant recipients and is associated with declining graft function. Sodium bicarbonate treatment effectively corrects metabolic acidosis, but no prospective studies have examined its effect on graft function. Therefore, we aimed to test whether sodium bicarbonate treatment would preserve graft function and slow the progression of estimated glomerular filtration rate (GFR) decline in kidney transplant recipients.