Publication

Conserved stromal-immune cell circuits secure B cell homeostasis and function.

Journal Paper/Review - May 18, 2023

Units
PubMed
Doi
Contact

Citation
Lütge M, De Martin A, Gil Cruz C, Perez Shibayama C, Stanossek Y, Onder L, Cheng H, Kurz L, Cadosch N, Soneson C, Robinson M, Stöckli S, Ludewig B, Pikor N. Conserved stromal-immune cell circuits secure B cell homeostasis and function. Nat Immunol 2023
Type
Journal Paper/Review (English)
Journal
Nat Immunol 2023
Publication Date
May 18, 2023
Issn Electronic
1529-2916
Brief description/objective

B cell zone reticular cells (BRCs) form stable microenvironments that direct efficient humoral immunity with B cell priming and memory maintenance being orchestrated across lymphoid organs. However, a comprehensive understanding of systemic humoral immunity is hampered by the lack of knowledge of global BRC sustenance, function and major pathways controlling BRC-immune cell interactions. Here we dissected the BRC landscape and immune cell interactome in human and murine lymphoid organs. In addition to the major BRC subsets underpinning the follicle, including follicular dendritic cells, PI16 RCs were present across organs and species. As well as BRC-produced niche factors, immune cell-driven BRC differentiation and activation programs governed the convergence of shared BRC subsets, overwriting tissue-specific gene signatures. Our data reveal that a canonical set of immune cell-provided cues enforce bidirectional signaling programs that sustain functional BRC niches across lymphoid organs and species, thereby securing efficient humoral immunity.