Unit
Division of Infectious Diseases, Infection Prevention and Travel Medicine
INFEKT · Dept. I
Resistance Development in Escherichia coli at different pH following Delafloxacin and Ciprofloxacin Challenge
Jan 1, 2021Delafloxacin , a novel dual-targeting non-zwitterionic fluoroquinolone, has received approval by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of acute bacterial skin and skin structure infectio...
Fundamental Research - Jan 1, 2021 - Jan 1, 2023
Automatically Closed
Project leader: Babouee Flury Baharak
Validation of COVID-19 risk stratification algorithms based on sTREM-1 and IL-6 in Emergency Departments: a retrospective multicenter cohort study
Dec 1, 2020We will retrospectively select SARS-CoV-2 infected adults who attended the ED of St.Gallen and Bellinzona. We want to measure the concentrations from stored blood samples of: Biomarkers of immune dysfunction: e.g., C reactive protein, procalciton...
Clinical Studies - Dec 1, 2020 - Apr 28, 2023
Completed
Project leader: Albrich Werner
SURPRISE+: SURveillance of infectious diseases among health PRofessionals In SwitzErland – a longitudinal, multicentre cohort
Sep 1, 2020In this multicentre healthcare worker cohort, we are studying risk factors, humoral immunity and long COVID symptoms in healthcare workers from 9 healthcare systems from Eastern and Northern Switzerland.
Healthcare Research - Sep 1, 2020 - Dec 31, 2023
Automatically Closed
Project leader: Kohler Philipp
CRiPSI/CRiPSI-X: Covid-19 Risk Prediction in Swiss ICUs-Trial/Extension
Aug 1, 2020Outcome of patients with critical Covid-19 varies. We study risk of and predictors for poor outcome in adult patients with Covid-19 admitted to ICU in a multicenter study. In addition, we assess the prevalence of, risk factors for and mechanisms invo...
Clinical Studies - Aug 1, 2020 - Aug 31, 2022
Automatically Closed
Project leader: Albrich Werner
Members: Von Mering Christian, O'Mahony Liam, Cerny Andreas, Suh Noémie, El Baz Yassir, Dietrich Tobias, Fischer Tim, Felbecker Ansgar, Göhl-Freyn Kristina, Germann Nicolas, Schmid Dagmar, Kahlert Christian, Frischknecht Manuel, Filipovic Miodrag, Brutsche Martin, Pietsch Urs, Kleger Gian-Reto, Bochud Pierre-Yves
Metabolism of antiretroviral drugs in HIV infected patients with toxicity – a pilot study
Jan 1, 2020Antiretroviral drugs can be responsible for a wide range of toxic side effects ranging from acute events to long-term toxicity. We hypothesize that the microbiome-mediated metabolism plays a substantial role in antiretroviral drug toxicity through se...
Clinical Studies - Jan 1, 2020 - Dec 31, 2020
Automatically Closed
Project leader: Notter Julia, Zimmermann Michael, Kahlert Christian
Multi-omic Approach with Genome editing to unravel the Resistance Mechanisms to Ceftazidime Avibactam in Pseudomonas aeruginosa,
Jun 20, 2019In this study, a collaborative work with EMBL Heidelberg, ETH- D BSSE Empa (Materials Science and Technology), we deciphered –hitherto unknown- resistance mechanisms of P. aeruginosa to ceftazidime- avibactam (CZA), a novel antibiotic with a multi-o...
Fundamental Research - Jun 20, 2019 - Jan 1, 2023
Automatically Closed
Project leader: Babouee Flury Baharak, Kogadeeva-Zimmermann Maria
First Experiences with Screening of Anal Intraepithelial Neoplasia (AIN): a Single Center Retrospective Data-Analysis
Sep 1, 2017Hintergrund Zwischen Human Papilloma Virus (HPV) und Analkrebs besteht eine starke Korrelation. Wie beim Cervixkarzinom der Frau sind mehr als 80% der Analkarzinome durch HPV bedingt. Analkrebs geht meist aus Vorläuferläsionen, den analen intraepithe...
Clinical Studies - Sep 1, 2017 - Sep 2, 2018
Automatically Closed
Project leader: Baumeler Stephan
Members: Maurus Christine, Marti Lukas, Borovicka Jan, Bock Susanne, Bischofberger Stephan, Schmid Patrick
Biofilms on short-term indwelling ureteral stents: Influence on associated symptoms and complications; Prediction by urine analysis; Current bacterial spectrum and antibiotic resistance
Oct 10, 2015Die Einlage von Harnleiterschienen ist im urologischen Alltag unverzichtbar. Sie ist jedoch mit erheblichen Beschwerden und Komplikationen verbunden. Die Möglichkeiten diese zu reduzieren sind beschränkt. Mit zunehmender Einlagedauer von Harnleitersc...
Clinical Studies - Oct 10, 2015 - Feb 10, 2018
Automatically Closed
Project leader: Abt Dominik
Members: Zumstein Valentin, Betschart Patrick, Qun Ren, Buhmann Matthias, Schmid Hans-Peter, Engeler Daniel, Albrich Werner
STD4free
Jan 1, 2015Studie zur Evaluation einer optimalen Teststrategie auf die wichtigsten sexuell übertragbaren Erkrankungen (STD) bei symptomfreien Personen
Clinical Studies - Jan 1, 2015 - Dec 31, 2015
Automatically Closed
Project leader: Vernazza Pietro
Clinical impact of multiplex realtime PCR in respiratory tract infections
Nov 15, 2014Pathogen detection in respiratory tract infections is challenging due to lack of diagnostic gold standard with sufficient sensitivity and specificity. Viral infections likely contribute to a considerable portion of respiratory tract infections partic...
Clinical Studies - Nov 15, 2014 - Dec 31, 2015
Automatically Closed
Project leader: Albrich Werner
Members: Kahlert Christian, Rassouli Frank, Mayer Lena
Airway microbiota resistome in CF - impact on clinical management
Sep 1, 2014Cystic Fibrosis is a deadly genetic disease mainly due to chronic bacterial colonization and recurrent bacterial infections of the lungs. It has often been documented that once a certain microbial species such as Pseudomonas aeruginosa establishes, t...
Fundamental Research - Sep 1, 2014 - Dec 31, 2016
Automatically Closed
Project leader: Baty Florent
Members: Brutsche Martin, Kahlert Christian, Von Mering Christian, Vyas Rounak
Human airway epithelia and pneumococcus. Polarized in vitro cell culture model to study interaction between human airway epithelia and pneumococcus
Jan 1, 2014This project aims to extend the existing human airway epithelial model to enable studies on the most relevant and lethal respiratory bacterial pathogen, Streptococcus pneumoniae (SP). The primary goal of this proposal is to show the feasibility of th...
Fundamental Research - Jan 1, 2014 - Dec 31, 2014
Automatically Closed
Project leader: Albrich Werner, Kahlert Christian
Positive Deviance in der Hepatitis C Behandlung
Nov 15, 2013Hepatitis C ist eine durch Blut übertragbare, infektiöse Leberentzündung, die durch das Hepatitis C Virus (HCV) hervorgerufen wird. Durch eine antivirale Behandlung können ernsthafte und behandlungsintensive Spätfolgen der Hepatitis C wie die Leberzi...
Clinical Studies - Nov 15, 2013 - Feb 28, 2015
Automatically Closed
Project leader: Nicca Dunja
Members: Vernazza Pietro, Rasi Manuela, Scharf Regina, Brugmann Philip, Fehr Jan
Unravelling the Evil - the role of CXCL-10 antagonist in HIV+ failing immune recovery despite cART
Jul 1, 2013Although highly active antiretroviral therapy (HAART) leads in general to CD4+ T-cell recovery and decrease of general immune activation, therefore improving individuals’ long-term prognosis, in a clinically significant percentage of 20% of HIV-infec...
Fundamental Research - Jul 1, 2013 - Apr 30, 2014
Automatically Closed
Project leader: Hoffmann Matthias
Members: Schmid Patrick, Kahlert Christian, Vernazza Pietro
Clinical evaluation of a polyvalent vaccine against Salmonella enterica in a phase I/II Study
Jun 1, 2013Salmonella enterica infections are an important global health problem with more than 20 million individuals suffering from enteric fever annually and more than 200’000 lethal cases per year. Although enteric fever can be treated appropriately with an...
Fundamental Research - Jun 1, 2013 - Dec 31, 2016
Automatically Closed
Project leader: Ludewig Burkhard, Vernazza Pietro
Members: Carreño Juan-Manuel
Prevention of hepatitis C virus (HCV) and HIV-1 co-infections through induction of potent T cell responses using prime-boost viral vector vaccine regimens (PEACHI)
Feb 1, 2013The goal of the PEACHI project funded by the European Commission (FP7 framework) is to develop simple, affordable and effective vaccine strategies that can be given alone or in combination to prevent hepatitis C virus (HCV), human immunodeficiency vi...
Clinical Studies - Feb 1, 2013 - Sep 27, 2022
Automatically Closed
Project leader: Dorrell Lucy, Barnes Ellie, Hoffmann Matthias, Bergin Colm, Folgori Antonella
Members: Schmid Patrick, Vernazza Pietro
Modulation of inflammation by Lactobacillus rhamnosus GG in pediatric patients with cystic fibrosis
Dec 1, 2012Die zystische Fibrose ist eine komplexe, genetisch determinierte aber bisher unheilbare Multiorganerkrankung mit phänotypischem Hauptmerkmal einer ätiologisch nicht sicher geklärten chronischen Entzündung im Respirationstrakt. Dies führt zu rezidivie...
Clinical Studies - Dec 1, 2012 - Dec 31, 2015
Automatically Closed
Project leader: Kahlert Christian, Müller Pascal
Polyfunctional T-cell profile and its association with antibody titers in HIV-infected individuals with low CD4-nadir after seasonal influenza vaccination (FLUvaccHIV)
Nov 12, 2012BACKGROUND INFORMATION Influenza-vaccination is one of the most potent preventive measures to protect vulnerable populations, e.g. HIV-infected patients. Nevertheless it is unknown if the immune system in HIV-infected patients is restored upon HIV t...
Fundamental Research - Nov 12, 2012 - Jul 12, 2013
Automatically Closed
Project leader: Hoffmann Matthias
Hepatitis C Behandlung mit Proteasehemmern: Erfahrungen und Bedürfnisse von Patienten im Alltag. Eine qualitative Multizenterstudie
Nov 2, 2012Hepatitis C ist eine durch Blut übertragbare, infektiöse Leberentzündung, hervorgerufen durch das Hepatitis C Virus (HCV). In der Schweiz sind schätzungsweise 50’000-70’000 Personen davon betroffen. Es wird davon ausgegangen, dass die Zahl behandlung...
Clinical Studies - Nov 2, 2012 - Mar 31, 2014
Completed
Project leader: Nicca Dunja
Members: Bruggmann Phillipe, Semela David, Schmid Patrick, Rasi Manuela, Künzler-Heule Patrizia
Interferon-γ Release Assay (IGRA) Negativity Rates after TB-Treatment in HIV-infected Individuals
Aug 15, 2012Background: Interferon-γ Release assays (IGRA) have partly replaced conventional tuberculin skin tests (TST) in the recent years due to their higher specificity and standardised test procedures including a positive / negative control. Nevertheless it...
Clinical Studies - Aug 15, 2012 - Aug 31, 2013
Automatically Closed
Project leader: Hoffmann Matthias
Members: Ruhwald Morten, Hasse Barbara, Fenner Lukas, Schmid Patrick, Vernazza Pietro