Unit
Institute of Immunobiology
IMMBIO · Management
The quorum sensing com system regulates pneumococcal colonisation and invasive disease in a pseudo-stratified airway tissue model.
Kahlert C, Nigg S, Onder L, Dijkman R, Diener L, Vidal A, Rodriguez R, Vernazza P, Thiel V, Vidal J, Albrich W. The quorum sensing com system regulates pneumococcal colonisation and invasive disease in a pseudo-stratified airway tissue model. Microbiol Res 2022; 268:127297.
Dec 31, 2022The quorum sensing com system regulates pneumococcal colonisation and invasive disease in a pseudo-stratified airway tissue model.
Dec 31, 2022Microbiol Res 2022; 268:127297
Kahlert Christian, Nigg Susanne, Onder Lucas, Dijkman Ronald, Diener Liliane, Vidal Ana G Jop, Rodriguez Regulo, Vernazza Pietro, Thiel Volker, Vidal Jorge E, Albrich Werner
Fibroblastic reticular cells mitigate acute graft-versus-host disease via MHCII-dependent maintenance of regulatory T cells.
Shaikh H, Pezoldt J, Mokhtari Z, Gamboa Vargas J, Le D, Peña Mosca J, Arellano-Viera E, Kern M, Graff C, Beyersdorf N, Lutz M, Riedel A, Büttner-Herold M, Zernecke A, Einsele H, Saliba A, Ludewig B, Huehn J, Beilhack A. Fibroblastic reticular cells mitigate acute graft-versus-host disease via MHCII-dependent maintenance of regulatory T cells. JCI Insight 2022
Oct 13, 2022Fibroblastic reticular cells mitigate acute graft-versus-host disease via MHCII-dependent maintenance of regulatory T cells.
Oct 13, 2022JCI Insight 2022
Shaikh Haroon, Pezoldt Joern, Mokhtari Zeinab, Gamboa Vargas Juan, Le Duc-Dung, Peña Mosca Josefina, Arellano-Viera Estibaliz, Kern Michael Ag, Graff Caroline, Beyersdorf Niklas, Lutz Manfred, Riedel Angela, Büttner-Herold Maike, Zernecke Alma, Einsele Hermann, Saliba Antoine-Emmanuel, Ludewig Burkhard, Huehn Jochen, Beilhack Andreas
Autoreactive napsin A-specific T cells are enriched in lung tumors and inflammatory lung lesions during immune checkpoint blockade.
Berner F, Bomze D, Lichtensteiger C, Walter V, Niederer R, Hasan Ali O, Wyss N, Bauer J, Freudenmann L, Marcu A, Wolfschmitt E, Haen S, Gross T, Abdou M, Diem S, Knöpfli S, Sinnberg T, Hofmeister K, Cheng H, Toma M, Klümper N, Purde M, Pop O, Jochum A, Pascolo S, Jörger M, Früh M, Jochum W, Rammensee H, Läubli H, Hölzel M, Neefjes J, Walz J, Flatz L. Autoreactive napsin A-specific T cells are enriched in lung tumors and inflammatory lung lesions during immune checkpoint blockade. Sci Immunol 2022; 7:eabn9644.
Sep 2, 2022Autoreactive napsin A-specific T cells are enriched in lung tumors and inflammatory lung lesions during immune checkpoint blockade.
Sep 2, 2022Sci Immunol 2022; 7:eabn9644
Berner Fiamma, Bomze David, Lichtensteiger Christa, Walter Vincent, Niederer Rebekka, Hasan Ali Omar, Wyss Nina, Bauer Jens, Freudenmann Lena Katharina, Marcu Ana, Wolfschmitt Eva-Maria, Haen Sebastian, Gross Thorben, Abdou Marie-Therese, Diem Stefan, Knöpfli Stella, Sinnberg Tobias, Hofmeister Kathrin, Cheng Hung-Wei, Toma Marieta, Klümper Niklas, Purde Mette-Triin, Pop Oltin Tiberiu, Jochum Ann-Kristin, Pascolo Steve, Jörger Markus, Früh Martin, Jochum Wolfram, Rammensee Hans-Georg, Läubli Heinz, Hölzel Michael, Neefjes Jacques, Walz Juliane, Flatz Lukas
Fibroblasts tune myocardial inflammation and remodeling
Pérez Shibayama C, Gil Cruz C, Ludewig B. Fibroblasts tune myocardial inflammation and remodeling. Nature Cardiovascular Research 2022; 1:694–695.
Aug 12, 2022Fibroblasts tune myocardial inflammation and remodeling
Aug 12, 2022Nature Cardiovascular Research 2022; 1:694–695
Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Ludewig Burkhard
Multitier mechanics control stromal adaptations in the swelling lymph node.
Assen F, Abe J, Hons M, Hauschild R, Shamipour S, Kaufmann W, Costanzo T, Krens G, Brown M, Ludewig B, Hippenmeyer S, Heisenberg C, Weninger W, Hannezo E, Luther S, Stein J, Sixt M. Multitier mechanics control stromal adaptations in the swelling lymph node. Nat Immunol 2022; 23:1246-1255.
Jul 11, 2022Multitier mechanics control stromal adaptations in the swelling lymph node.
Jul 11, 2022Nat Immunol 2022; 23:1246-1255
Assen Frank P, Abe Jun, Hons Miroslav, Hauschild Robert, Shamipour Shayan, Kaufmann Walter A, Costanzo Tommaso, Krens Gabriel, Brown Markus, Ludewig Burkhard, Hippenmeyer Simon, Heisenberg Carl-Philipp, Weninger Wolfgang, Hannezo Edouard, Luther Sanjiv A, Stein Jens V, Sixt Michael
Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naive B cells.
Gómez Atria D, Gaudette B, Londregan J, Kelly S, Perkey E, Allman A, Srivastava B, Koch U, Radtke F, Ludewig B, Siebel C, Ryan R, Robertson T, Burkhardt J, Pear W, Allman D, Maillard I. Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naive B cells. J Clin Invest 2022; 132
Jul 1, 2022Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naive B cells.
Jul 1, 2022J Clin Invest 2022; 132
Gómez Atria Daniela, Gaudette Brian T, Londregan Jennifer, Kelly Samantha, Perkey Eric, Allman Anneka, Srivastava Bhaskar, Koch Ute, Radtke Freddy, Ludewig Burkhard, Siebel Christian W, Ryan Russell Jh, Robertson Tanner F, Burkhardt Janis K, Pear Warren S, Allman David, Maillard Ivan
Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function
Cheng H, Scandella E, Hehlgans T, Pérez Shibayama C, Gil Cruz C, Novkovic M, Onder L, Engetschwiler C, Lütge M, Mörbe U, Ludewig B. Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function. Nat Commun 2022; 13:2027.
Apr 19, 2022Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function
Apr 19, 2022Nat Commun 2022; 13:2027
Cheng Hung-Wei, Scandella Elke, Hehlgans T, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Novkovic M, Onder Lucas, Engetschwiler Céline, Lütge Mechthild, Mörbe Urs, Ludewig Burkhard
C reactive protein flare predicts response to checkpoint inhibitor treatment in non-small cell lung cancer.
Klümper N, Saal J, Berner F, Lichtensteiger C, Wyss N, Heine A, Bauernfeind F, Ellinger J, Brossart P, Diem S, Schmid S, Jörger M, Frueh M, Ritter M, Hölzel M, Flatz L, Bald T. C reactive protein flare predicts response to checkpoint inhibitor treatment in non-small cell lung cancer. J Immunother Cancer 2022; 10
Mar 1, 2022C reactive protein flare predicts response to checkpoint inhibitor treatment in non-small cell lung cancer.
Mar 1, 2022J Immunother Cancer 2022; 10
Klümper Niklas, Saal Jonas, Berner Fiamma, Lichtensteiger Christa, Wyss Nina, Heine Annkristin, Bauernfeind Franz Georg, Ellinger Jörg, Brossart Peter, Diem Stefan, Schmid Sabine, Jörger Markus, Frueh Martin, Ritter Manuel, Hölzel Michael, Flatz Lukas, Bald Tobias
Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node.
Li C, Ward L, Nguyen A, Lam E, Dasoveanu D, Ahmed M, Haniuda K, Buechler M, He H, Ludewig B, McNagny K, Gommerman J. Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node. Mucosal Immunol 2022; 15:418-427.
Feb 18, 2022Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node.
Feb 18, 2022Mucosal Immunol 2022; 15:418-427
Li Conglei, Ward Lesley A, Nguyen Albert, Lam Evelyn, Dasoveanu Dragos C, Ahmed Musaddeque, Haniuda Kei, Buechler Matthew B, He Housheng Hansen, Ludewig Burkhard, McNagny Kelly Marshall, Gommerman Jennifer L
A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity
Alexandre Y, Belz G, Ludewig B, Haque A, Mackay L, D'Costa R, Starkey G, Gordon C, Christo S, Cao W, Groom J, Pal B, Devi S, Williams C, Gandolfo L, Lee H, Schienstock D, Mueller S. A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity. Sci Immunol 2022; 7:eabj0641.
Jan 7, 2022A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity
Jan 7, 2022Sci Immunol 2022; 7:eabj0641
Alexandre Yannick O, Belz Gabrielle T, Ludewig Burkhard, Haque Ashraful, Mackay Laura K, D'Costa Rohit, Starkey Graham, Gordon Claire L, Christo Susan N, Cao Wang, Groom Joanna R, Pal Bhupinder, Devi Sapna, Williams Cameron G, Gandolfo Luke C, Lee Hyun Jae, Schienstock Dominik, Mueller Scott N
Postvaccination anti-S IgG levels predict anti-SARS-CoV-2 neutralising activity over 24 weeks in patients with RA.
Schmiedeberg K, Abela I, Pikor N, Vuilleumier N, Schwarzmueller M, Epp S, Pagano S, Grabherr S, Patterson A, Nussberger M, Trkola A, Ludewig B, von Kempis J, Rubbert-Roth A. Postvaccination anti-S IgG levels predict anti-SARS-CoV-2 neutralising activity over 24 weeks in patients with RA. RMD Open 2022; 8
Jan 1, 2022Postvaccination anti-S IgG levels predict anti-SARS-CoV-2 neutralising activity over 24 weeks in patients with RA.
Jan 1, 2022RMD Open 2022; 8
Schmiedeberg Kristin, Abela Irene A, Pikor Natalia, Vuilleumier Nicolas, Schwarzmueller Magdalena, Epp Selina, Pagano Sabrina, Grabherr Sarah, Patterson Angelica Brooke, Nussberger Madalina, Trkola Alexandra, Ludewig Burkhard, von Kempis Johannes, Rubbert-Roth Andrea
Anti-S1 Antibodies After Vaccination with Anti SARS-CoV-2 mRNA Vaccines in Patients with Rheumatoid Arthritis Differ in Magnitude and Kinetics from Healthy Controls: Results from a Prospective, Observational Controlled Study
Rubbert-Roth A, Vuilleumier N, Ludewig B, Schmiedeberg K, Rottländer Y, Pirker I, von Kempis J (2022). Anti-S1 Antibodies After Vaccination with Anti SARS-CoV-2 mRNA Vaccines in Patients with Rheumatoid Arthritis Differ in Magnitude and Kinetics from Healthy Controls: Results from a Prospective, Observational Controlled Study.
Dec 28, 2021Anti-S1 Antibodies After Vaccination with Anti SARS-CoV-2 mRNA Vaccines in Patients with Rheumatoid Arthritis Differ in Magnitude and Kinetics from Healthy Controls: Results from a Prospective, Observational Controlled Study
Dec 28, 2021ACR Converence 2021
Rubbert-Roth Andrea, Vuilleumier Nicolas, Ludewig Burkhard, Schmiedeberg Kristin, Rottländer Yella, Pirker Ian, von Kempis Johannes
Presence of autoantibodies in serum does not impact the occurrence of immune checkpoint inhibitor-induced hepatitis in a prospective cohort of cancer patients.
Purde M, Niederer R, Wagner N, Diem S, Berner F, Hasan Ali O, Hillmann D, Bergamin I, Jörger M, Risch M, Niederhauser C, Lenz T, Früh M, Risch L, Semela D, Flatz L. Presence of autoantibodies in serum does not impact the occurrence of immune checkpoint inhibitor-induced hepatitis in a prospective cohort of cancer patients. J Cancer Res Clin Oncol 2021; 148:647-656.
Dec 7, 2021Presence of autoantibodies in serum does not impact the occurrence of immune checkpoint inhibitor-induced hepatitis in a prospective cohort of cancer patients.
Dec 7, 2021J Cancer Res Clin Oncol 2021; 148:647-656
Purde Mette-Triin, Niederer Rebekka, Wagner Nikolaus, Diem Stefan, Berner Fiamma, Hasan Ali Omar, Hillmann Dorothea, Bergamin Irina, Jörger Markus, Risch Martin, Niederhauser Christoph, Lenz Tobias L, Früh Martin, Risch Lorenz, Semela David, Flatz Lukas
Visualization and functional characterization of lymphoid organ fibroblasts
Onder L, Cheng H, Ludewig B. Visualization and functional characterization of lymphoid organ fibroblasts. Immunol Rev 2021
Dec 5, 2021Visualization and functional characterization of lymphoid organ fibroblasts
Dec 5, 2021Immunol Rev 2021
Onder Lucas, Cheng Hung-Wei, Ludewig Burkhard
Anti-SARS-CoV-2 mRNA vaccines as inducers of humoral response against apolipoprotein A-1?
Vuilleumier N, Pagano S, Ludewig B, Schmiedeberg K, Haller C, von Kempis J, Rubbert-Roth A. Anti-SARS-CoV-2 mRNA vaccines as inducers of humoral response against apolipoprotein A-1?. Eur J Clin Invest 2021; 52:e13713.
Nov 29, 2021Anti-SARS-CoV-2 mRNA vaccines as inducers of humoral response against apolipoprotein A-1?
Nov 29, 2021Eur J Clin Invest 2021; 52:e13713
Vuilleumier Nicolas, Pagano Sabrina, Ludewig Burkhard, Schmiedeberg Kristin, Haller Christoph, von Kempis Johannes, Rubbert-Roth Andrea
Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival.
Berner F, Niederer R, Luimstra J, Pop O, Jochum A, Purde M, Hasan Ali O, Bomze D, Bauer J, Freudenmann L, Marcu A, Wolfschmitt E, Haen S, Gross T, Dubbelaar M, Abdou M, Baumgaertner P, Appenzeller C, Cicin-Sain C, Lenz T, Speiser D, Ludewig B, Driessen C, Jörger M, Früh M, Jochum W, Cozzio A, Rammensee H, Walz J, Neefjes J, Flatz L. Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival. Oncoimmunology 2021; 10:2006893.
Nov 27, 2021Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival.
Nov 27, 2021Oncoimmunology 2021; 10:2006893
Berner Fiamma, Niederer Rebekka, Luimstra Jolien J, Pop Oltin Tiberiu, Jochum Ann-Kristin, Purde Mette-Triin, Hasan Ali Omar, Bomze David, Bauer Jens, Freudenmann Lena Katharina, Marcu Ana, Wolfschmitt Eva-Maria, Haen Sebastian, Gross Thorben, Dubbelaar MariLisa, Abdou Marie-Therese, Baumgaertner Petra, Appenzeller Christina, Cicin-Sain Caroline, Lenz Tobias, Speiser Daniel E, Ludewig Burkhard, Driessen Christoph, Jörger Markus, Früh Martin, Jochum Wolfram, Cozzio Antonio, Rammensee Hans-Georg, Walz Juliane, Neefjes Jacques, Flatz Lukas
Efficacy and tolerability of a third dose of an mRNA anti-SARS-CoV-2 vaccine in patients with rheumatoid arthritis with absent or minimal serological response to two previous doses
Schmiedeberg K, Vuilleumier N, Pagano S, Albrich W, Ludewig B, von Kempis J, Rubbert-Roth A. Efficacy and tolerability of a third dose of an mRNA anti-SARS-CoV-2 vaccine in patients with rheumatoid arthritis with absent or minimal serological response to two previous doses. Lancet Rheumatol 2021; 4:e11-e13.
Oct 26, 2021Efficacy and tolerability of a third dose of an mRNA anti-SARS-CoV-2 vaccine in patients with rheumatoid arthritis with absent or minimal serological response to two previous doses
Oct 26, 2021Lancet Rheumatol 2021; 4:e11-e13
Schmiedeberg Kristin, Vuilleumier Nicolas, Pagano Sabrina, Albrich Werner, Ludewig Burkhard, von Kempis Johannes, Rubbert-Roth Andrea
Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment
Ring S, Spiegl M, Besse A, Bonilla W, Stemeseder F, Schmidt S, Orlinger K, Krebs P, Ludewig B, Wenger R, Hartmann F, Cupovic J, Onder L, Lütge M, Pérez Shibayama C, Gil Cruz C, Scandella E, De Martin A, Mörbe U, Flatz L. Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment. Nat Commun 2021; 12:4734.
Aug 5, 2021Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment
Aug 5, 2021Nat Commun 2021; 12:4734
Ring Sandra, Spiegl Matthias, Besse Andrej, Bonilla Weldy V, Stemeseder Felix, Schmidt Sarah, Orlinger Klaus K, Krebs Philippe, Ludewig Burkhard, Wenger Robert, Hartmann Fabienne, Cupovic Jovana, Onder Lucas, Lütge Mechthild, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Scandella Elke, De Martin Angelina, Mörbe Urs, Flatz Lukas
Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks
Acton S, Onder L, Novkovic M, Martinez V, Ludewig B. Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks. Trends Immunol 2021; 42:782-794.
Aug 3, 2021Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks
Aug 3, 2021Trends Immunol 2021; 42:782-794
Acton Sophie E, Onder Lucas, Novkovic Mario, Martinez Victor G, Ludewig Burkhard
Distinct microbial communities colonize tonsillar squamous cell carcinoma.
De Martin A, Lütge M, Stanossek Y, Engetschwiler C, Cupovic J, Brown K, Demmer I, Broglie M, Geuking M, Jochum W, McCoy K, Stöckli S, Ludewig B. Distinct microbial communities colonize tonsillar squamous cell carcinoma. Oncoimmunology 2021; 10:1945202.
Jul 25, 2021Distinct microbial communities colonize tonsillar squamous cell carcinoma.
Jul 25, 2021Oncoimmunology 2021; 10:1945202
De Martin Angelina, Lütge Mechthild, Stanossek Yves, Engetschwiler Céline, Cupovic Jovana, Brown Kirsty, Demmer Izadora, Broglie Martina Anja, Geuking Markus B, Jochum Wolfram, McCoy Kathy D, Stöckli Sandro, Ludewig Burkhard