Projects
Search from 1164 projects:
1164 Project(s)
Systems biology approach to molecularly characterize the lung cancer microenvironment
Jan 1, 2013Lung cancer is the most frequent cause of death in cancer patients in industrialized countries. Most patients with advanced nonsmall cell lung cancer (NSCLC) do not respond to the current treatment schemes indicating that the basic mechanisms of tumo...
Fundamental Research - Jan 1, 2013 - Dec 31, 2014
Completed
Project leader: Ludewig Burkhard, Brutsche Martin
Members: Baty Florent, Novkovic Mario, Onder Lucas
Role CCR7-ligands in virus-induced chronic CNS inflammation and demyelination
Jan 1, 2013Background: Epidemiological studies indicate that onset and progression of multiple sclerosis (MS) critically depends on environmental factors, including infectious agents. Experimental infections with neurotropic viruses can precipitate MS-like path...
Fundamental Research - Jan 1, 2013 - Dec 31, 2013
Completed
Project leader: Ludewig Burkhard
Members: Gil Cruz Cristina, Cupovic Jovana
Secretome analysis of the human airway epithelium following human respiratory virus infection
Jan 1, 2013The human airway epithelium represents the entry port of many human respiratory viruses, such as respiratory syncytial virus (RSV), influenza A viruses (IAV), and human coronaviruses (HCoV). It represents the interface between the external world and...
Fundamental Research - Jan 1, 2013 - Dec 31, 2013
Completed
Project leader: Thiel Volker
Members: Dijkman Ronald, Jonsdottir Hulda
Development and preclinical characterization of third-generation proteasome inhibitors
Jan 1, 2013After validation of the proteasome as a prime target for innovative oncology drugs, the peptide borate bortezomib was approved as first in class proteasome inhibiting drug. Bortezomib provides reversible inhibition of the proteasomal beta 1 and beta...
Clinical Studies - Jan 1, 2013 - Dec 31, 2015
Automatically Closed
Project leader: Driessen Christoph
Members: Kraus Marianne
Improved adherence to CPAP by Telemetric Support in Newly diagnosed OSAS Patients
Jan 1, 2013Introduction: The acceptance of positive airway pressure therapy (CPAP) within the first month is a critical aspect of successful OSAS therapy. Telemedicine is a novel tool to supervise CPAP use at patient's home. We report 30-day results of a pilot...
Fundamental Research - Jan 1, 2013 - Mar 1, 2013
Completed
Project leader: Schoch Otto, Brutsche Martin
Members: Baty Florent, Niedermann Jolanda, Rüdiger Jochen
In vitro proteotoxic synergism of nelfinavir and carfilzomib in solid cancer cell lines
Jan 1, 2013HER2-positive breast cancer accounts for approximately 25-30% of all breast cancer cases, and carries a bad prognosis compared to HER2-negative breast cancer. Despite recent advances with the development of HER2-targeted treatments, mainly trastuzuma...
Fundamental Research - Jan 1, 2013 - Dec 31, 2014
Automatically Closed
Members: Driessen Christoph, Gibbons-Marsico Jennifer, Kraus Marianne
Clinical and MRI based predictors of prolonged dysphagia in ischemic stroke
Jan 1, 2013Background With an incidence of approximately 55% swallowing disorders after ischemic stroke are a regular issue and can lead to complications like pneumonia, malnutrition and dehydration. The presence of dysphagia in stroke patients may be associat...
Clinical Studies - Jan 1, 2013 - Jul 31, 2014
Completed
Project leader: Kägi Georg
Members: Galovic Marian, Weder Bruno, Stöckli Sandro, Leisi Natascha, Müller Marlise, Weber Johannes
Telemedicine to enhance CPAP adherence in OSAS - A randomized placebo-controlled prospective study
Jan 1, 2013We hypothesize that the use of telemedicine combined with support interventions by short messages, telephone calls and ambulatory visits to control CPAP treatment in OSAS patients during the first month improves adherence and reduces unresolved side...
Clinical Studies - Jan 1, 2013 - Dec 31, 2015
Completed
Project leader: Schoch Otto
Members: Baty Florent, Niedermann Jolanda, Brutsche Martin
Swiss Multiple Sclerosis Cohort-Study (SMSC-Study): A Prospective Swiss wide Investigation of Key Phases in Disease Evolution and new Treatment options
Jan 1, 2013The key aims of the Swiss Multiple Sclerosis Cohort-Study (SMSC) are (1) To maintain a long-term cohort (>10 years) representative of the MS population currently living in Switzerland. This requires effective measures to limit drop-outs and the conti...
Clinical Studies - Jan 1, 2013 - Nov 30, 2022
Automatically Closed
Project leader: Müller Stefanie
Clinical and biological characterization of Male Breast Cancer: an international retrospective EORTC, BIG and NABCG intergroup study
Dec 19, 2012Brustkrebs bei Männern ist selten und wir wissen fast nichts Gesichertes über die Behandlung. Persönliche Erfahrungen und berichtete Fallserien dienen zur Extrapolation von Behandlungsempfehlungen. Die BreastInterGroup BIG und die Führung der EORTC s...
Clinical Studies - Dec 19, 2012 - Mar 1, 2013
Automatically Closed
Project leader: Thürlimann Beat
Members: Riniker Salome, Kaelin Martin
Modulation of inflammation by Lactobacillus rhamnosus GG in pediatric patients with cystic fibrosis
Dec 1, 2012Die zystische Fibrose ist eine komplexe, genetisch determinierte aber bisher unheilbare Multiorganerkrankung mit phänotypischem Hauptmerkmal einer ätiologisch nicht sicher geklärten chronischen Entzündung im Respirationstrakt. Dies führt zu rezidivie...
Clinical Studies - Dec 1, 2012 - Dec 31, 2015
Automatically Closed
Project leader: Kahlert Christian, Müller Pascal
Treatment of non-alcoholic steatohepatitis (NASH) patients with vitamin D
Nov 21, 2012Die Fettlebererkrankung ist eine global stark zunehmende Erkrankung, die insbesondere bei begleitender Entzündung der Leber (Fettleberhepatitis; NASH) zumeist zu einem fortschreitenden Leberschaden führt. Das Endstadium dieser Erkrankung bilden die L...
Clinical Studies - Nov 21, 2012 - Mar 31, 2015
Automatically Closed
Project leader: Semela David
Members: Sawatzki Mikael, Sulz Michael, Borovicka Jan, Weinmann Sabine, Künzler-Heule Patrizia
ORIGINALE
Nov 19, 2012Importance of Long-Term Follow-up of the ORIGIN Participants, the ORIGINALE (ORIGIN and Legacy Effects) Study
Clinical Studies - Nov 19, 2012 - Nov 19, 2016
Completed
Project leader: Brändle Michael
Members: Rickli Hans, Gemperle Michaela
Polyfunctional T-cell profile and its association with antibody titers in HIV-infected individuals with low CD4-nadir after seasonal influenza vaccination (FLUvaccHIV)
Nov 12, 2012BACKGROUND INFORMATION Influenza-vaccination is one of the most potent preventive measures to protect vulnerable populations, e.g. HIV-infected patients. Nevertheless it is unknown if the immune system in HIV-infected patients is restored upon HIV t...
Fundamental Research - Nov 12, 2012 - Jul 12, 2013
Automatically Closed
Project leader: Hoffmann Matthias
Hepatitis C Behandlung mit Proteasehemmern: Erfahrungen und Bedürfnisse von Patienten im Alltag. Eine qualitative Multizenterstudie
Nov 2, 2012Hepatitis C ist eine durch Blut übertragbare, infektiöse Leberentzündung, hervorgerufen durch das Hepatitis C Virus (HCV). In der Schweiz sind schätzungsweise 50’000-70’000 Personen davon betroffen. Es wird davon ausgegangen, dass die Zahl behandlung...
Clinical Studies - Nov 2, 2012 - Mar 31, 2014
Completed
Project leader: Nicca Dunja
Members: Bruggmann Phillipe, Semela David, Schmid Patrick, Rasi Manuela, Künzler-Heule Patrizia
SMiLE-Lebenssinn, persönliche Werte und Spiritualität bei Patienten mit lebensbedrohlichen Erkrankungen (NFP 67)
Nov 1, 2012Zusammenfassung des Studienprotokolls Principal Investigator : Professor Gian Domenico Borasio, Universitätsspital Lausanne Co-Investigatoren : Mathieu Bernhard, Universitätsspital Lausanne; Dr. Claudia Gamondi Palmesino, Regionalspital Bellinzona...
Clinical Studies - Nov 1, 2012 - Oct 31, 2014
Completed
Project leader: Strasser Florian
Members: Wilm Simone, Magayakalbermatten N
Endoskopie in der Neurochirurgie
Nov 1, 2012Der allgemeine Zweck dieser Projekte ist die Techniken und deren Komplikationen bei den Pathologien intraventrikulär und der vorderen Schädelbasis zu untersuchen. Einerseits in der Hinsicht auf zukünftige prospektive Studien, und auch zur Qualitätszw...
Clinical Studies - Nov 1, 2012 - Nov 1, 2013
Automatically Closed
Project leader: Engel Doortje, Fournier Jean-Yves
Members: Huscher Karen, Heidrun Lange, Cem Yetimoglu
Neurochirurgische Behandlung von Neurovaskuläre Konflikte
Nov 1, 2012Wenn ein Hirnnerv durch ein Gefäss komprimiert oder irritiert wird und damit eine Reizung des Hirnnervs mit entsprechender Klinik verursacht wird, spricht man von einem neurovaskulären Konflikt. Die Symptome können von Zuckungen bis hin zu stärksten...
Clinical Studies - Nov 1, 2012 - Nov 1, 2013
Automatically Closed
Project leader: Engel Doortje, Fournier Jean-Yves, Cem Yetimoglu, Heidrun Lange, Huscher Karen
Traumatische Dissektion der ACI und A. Vertebralis: Screening- und Behandlungsunterschieden
Nov 1, 2012Dissektion der A. carotis interna und A. vertebralis nach Schädelhirntrauma (SHT) ist eine seltene Diagnose. Die Inzidenz könnte 1 pro 100.000 SHT Patienten sein (Stengel et al., 2007), richtige Inzidenzzahlen liegen jedoch nicht vor. Es gibt verschi...
Clinical Studies - Nov 1, 2012 - Feb 1, 2012
Automatically Closed
Project leader: Engel Doortje, Jung Carla
pre-MENAC
Oct 28, 2012
Clinical Studies - Oct 28, 2012 - Sep 26, 2013
Completed
Project leader: Strasser Florian
Members: Wilm Simone, Magayakalbermatten N