Projects
Search from 1147 projects:
221 Project(s)
STORM: A randomized phase II Trial for the Salvage Treatment of OligoRecurrent nodal prostate cancer Metastases
Jun 1, 2019To compare metastases-free survival (MFS) between metastasis-directed therapy and metastases-directed therapy with whole pelvis radiotherapy for oligorecurrent nodal prostate cancer. Target: 178 Patients
Clinical Studies - Jun 1, 2019 - Jul 1, 2025
Ongoing
Project leader: Putora Paul Martin
Akupunktur bei chemotherapieinduzierter Dysgeusie – eine randomisierte kontrollierte Studie
Jun 1, 2019Geschmacksstörungen (Dysgeusie) während einer Chemotherapie aufgrund einer Krebserkrankung sind häufig und beeinträchtigen die Lebensqualität erheblich. Bisher gibt es keine wirksamen Behandlungsmassnahmen. In einer randomisierten, kontrollierten, ve...
Clinical Studies - Jun 1, 2019 - Dec 31, 2024
Ongoing
Project leader: Schlaeppi Marc
ENIGMA: Open label, non-randomized, Phase IB study to character-ize safety, tolerability and recommended dose of EDO-S101, a first-in-class alkylating histone deacetylase inhibition (HDACi) fusion molecule, in combination with Nivolumab in patients with refractory, locally advanced or metastatic melanoma
May 2, 2019Neuere Immuntherapien zur Behandlung des fortgeschrit-tenen, metastasierten Melanoms haben zu einer Verbesse-rung des Gesamtüberlebens geführt. Diese Immuntherapien führen zu einer Verstärkung der natürlichen Krebsabwehr durch das Immunsystem. Einig...
Clinical Studies - May 2, 2019 - Dec 31, 2024
Ongoing
Project leader: Jörger Markus
Members: Wittwer Yvonne, Quinter Janine
MSD-MK-3475 KEYNOTE 937
May 1, 2019A Phase 3 Double-blinded, Two-arm Study to Evaluate the Safety and Efficacy of Pembrolizumab (MK-3475) versus Placebo as Adjuvant herapy in Participants ith Hepatocellular Carcinoma and Complete Radiological Response after Surgical esection or Local...
Clinical Studies - May 1, 2019 - May 1, 2026
Ongoing
Project leader: Semela David
Members: Stillhard Roman
Peace-4
Apr 26, 2019Prostate cancer is the most frequent cancer in Western countries and castrate- resistant prostate cancer (CRPC) is its lethal form. Survival for CRPC patients with metastases now encompasses 30 months, while that for patients without metastases is ab...
Clinical Studies - Apr 26, 2019 - May 6, 2027
Ongoing
Project leader: Omlin Aurelius
A Phase 3 Study Comparing Daratumumab, VELCADE (borte-zomib), Lenalidomide, and Dexamethasone (D-VRD) vs VELCADE, Lenalidomide, and Dexamethasone (VRD) in Sub-jects with Previously Untreated Multiple Myeloma who are Eligi-ble for High-dose Therapy
Apr 18, 2019This is a randomized, open-label, multicenter study evalu-ating subjects with newly diagnosed multiple myeloma who are deemed eligible for high-dose therapy. Approximately 690 subjects will be stratified by International Staging Sys-tem (ISS) Stage I...
Clinical Studies - Apr 18, 2019 - Dec 1, 2029
Ongoing
Project leader: Silzle Tobias
Abbvie M16-852 A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and
Apr 2, 2019Giant Cell Arteritis: Phase 3 Safety and Efficacy Study of Upadacitinib in Subjects with Giant Cell Arteritis
Clinical Studies - Apr 2, 2019 - Dec 31, 2024
Ongoing
Project leader: Rubbert-Roth Andrea
Members: Hutz Carina Liane, Bartz-Batliner Mira, Neumann Thomas, Peischl Riana, Sasselli Clelia
iModern
Jan 20, 2019Titel: instantaneous wave-free ratio guided Multivessel revascularizatiOn During percutaneous coronary intervEntion for acute myocaRdial iNfarction Objective: To compare an iFR-guided intervention of noninfarct lesions during the acute interventi...
Clinical Studies - Jan 20, 2019 - Dec 31, 2024
Ongoing
Project leader: Rigger Johannes
Members: Schneider Irene
A prospective randomized, parallel-group, multicentre, superiority trial of the SUPERA peripheral stent system in patients with femoro-popliteal artery disease
Jan 1, 2019The primary objective of the study is to investigate, if the Supera® Peripheral Stent System has clinical superiority over EverFlex™ Self-Expanding Peripheral Stent System with Entrust™ Delivery System or as Protégé™ EverFlex™, a standard self-expand...
Clinical Studies - Jan 1, 2019 - Dec 31, 2025
Ongoing
Project leader: Hechelhammer Lukas
Members: Dick Florian, von Allmen Regula, Benecke Ulf, Baumer Andrea, Koeger Philipp, Stillhard Roman
Prospective Observational international Registry of Patients with newly diagnosed peripheral T-Cell Lymphoma
Jan 1, 2019
Clinical Studies - Jan 1, 2019 - Dec 31, 2030
Ongoing
Project leader: Hitz Felicitas
Members: Demmer-Steingruber Ruth, Müller Fiona
TLD-1, a novel Liposomal Doxorubicin, in Patients with Advanced Solid Tumors; a multicenter open-label single-arm phase I trial.
Oct 26, 2018In dieser Studie wird zum ersten Mal die Sicherheit und Wirksamkeit eines neuen Medikaments (Talidox) bei Menschen untersucht. Bei dem neuen Medikament handelt es sich um einen bekannten Wirkstoff, das Chemotherapeutikum Doxorubicin, welches in einer...
Clinical Studies - Oct 26, 2018 - Dec 31, 2026
Ongoing
Project leader: Hess Dagmar
Members: Harder Anja, Quinter Janine
Tailored AXILLary Surgery with or without axillary lymph node dissection followed by radotherapy in patients with clinically node-positive breast cancer (TAXIS)
Jul 30, 2018The removal of all lymph nodes in the armpit through con-ventional axillary dissection has been standard care for all patients with breast cancer for almost a century. In the nineties, the sentinel lymph node (SLN) procedure, which involves the selec...
Clinical Studies - Jul 30, 2018 - Dec 12, 2030
Ongoing
Project leader: Bekes Inga
Members: Sennhauser Andrina, Müller Fiona
Randomisierte, offene, multizentrische Phase-2/3-Studie zur Beurteilung der Wirksamkeit und Sicherheit von Ro-garatinib (BAY 1163877) im Vergleich zu Chemotherapie bei Patienten mit FGFR-positivem, lokal fortgeschritte-nem oder metastatischem Urothelkarzinom, die vorher eine platinhaltige Chemotherapie erhalten haben
May 30, 2018Rogaratinib ist ein oraler pan-FGFR inhibitor. Eine FGFR-Überexpression (vorallem FGFR3 isoform) kann in bis zu 40% aller Patienten mit metastasiertem Urothelkarzinom nachgewiesen werden und stellt einen oncogenic driver da. Die Studie untersucht Rog...
Clinical Studies - May 30, 2018 - Dec 31, 2030
Ongoing
Project leader: Schmid Sabine
Multicentre Oberservational Study of MDS Patients in Switzerland- Swiss MDS Registry
May 17, 2018Die Myelodysplastischen Syndrome (MDS) umfassen eine heterogene Gruppe hämatologischer Stammzellerkran-kungen, welche durch Reifungsstörungen des Knochen-markes (Dysplasien) mit Verminderung der Blutzellen (Zy-topenien) charakterisiert sind. Das Spek...
Clinical Studies - May 17, 2018 - Aug 14, 2030
Ongoing
Project leader: Silzle Tobias
Members: Steiner Marianne
Takotsubo - Clinical Characteristics of Takotsubo Cardiomyopathy
Apr 1, 2018Takotsubo Cardiomyopathy, or broken heart syndrome, is a recently described acquired form of cardiomyopathy whose pathophysiology is not well understood and particularly affects postmenopausal women. The exact mechanism is still unclear and large p...
Clinical Studies - Apr 1, 2018 - Dec 31, 2030
Ongoing
Project leader: Jörg Lucas
Members: Fink Karin, Schneider Irene
TRIANGLE: autologous Transplantation after a Rituxi-mab/Ibrutinib/Ara-c containing iNduction in Generalized mantle cell Lymphoma – a randomized European mcl net-work trial
Feb 20, 2018According to current European guidelines (Dreyling, Ann Oncol 2014), the standard of care in younger patients with mantle cell lymphoma (MCL) is a dose-intensified approach with a cytarabine containing immunochemotherapy induction followed by autolog...
Clinical Studies - Feb 20, 2018 - Jan 31, 2028
Ongoing
Project leader: Hitz Felicitas
Abbvie M15-572 Phase 3 PsA mit inadäquater Response auf bDMARD
Oct 2, 2017A Phase 3, Randomized, Double-Blind, Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Subjects with Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Non-Biologic Disease Modifying Anti-Rheumat...
Clinical Studies - Oct 2, 2017 - Oct 3, 2024
Ongoing
Project leader: Rubbert-Roth Andrea
Members: Bartz-Batliner Mira, Hutz Carina Liane, Neumann Thomas
SAKK 08/15 PROMET
Sep 27, 2017PROMET - Multicenter, Randomized Phase II Trial of Salvage Radiotherapy +/- Metformin for Patients with Prostate Cancer after Prostatectomy The main objective of the trial is to explore the efficacy of SRT plus metformin compared to SRT in the endpo...
Clinical Studies - Sep 27, 2017 - Oct 7, 2030
Ongoing
Project leader: Putora Paul Martin
Members: Panje Cédric
TOASST
Jul 1, 2017Die Studie soll die Hypothese prüfen, dass auch nach längerer Behandlungsdauer mit Prednison®, Spiricort® oder einem verwandten Produkt auf ein langsames Ausschleichen der Dosis verzichtet werden darf, ohne dass dadurch ein schlechterer Verlauf resul...
Clinical Studies - Jul 1, 2017 - Dec 31, 2025
Ongoing
Project leader: Brändle Michael
Members: Drescher Tilman, Baerlocher Lorenz, Hörburger David, Räss Andrea, Grillmayr Victoria
SAKK PRODIGE 32: Systematic surgery vs monitoring and salvage surgery in opera-ble oesophageal cancer in complete clinical response after chemoradiation Strategic multicenter randomized phase II- III trial
Mar 28, 2017Patients with locally advanced oesophageal cancer are evaluable for a participation in this trial. The standard treatment for these patients is neoadjuvant chemoradia-tion followed by surgery. Patients receiving a complete pathological remission afte...
Clinical Studies - Mar 28, 2017 - Sep 30, 2024
Ongoing
Project leader: Ruhstaller Thomas