Prospektive nicht-interventionelle Studie zur optimierten Behandlung einer therapierefraktären Hypercholesterinämie bei Patienten mit heterozygoter familiärer Hypercholesterinämie oder klinisch manifester atherosklerotischer kardiovaskulärer Erkranku...

Clinical Studies - Apr 8, 2019 - Jan 15, 2021

Completed

Project leader: Rickli Hans
Members: Gemperle Michaela

This study assesses in a pilot trial the effect of PDE-5 inhibition with Tadalafil on RV size and function, exercise capacity and neurohumoral activation in adults with a systemic RV over a 3-year follow-up period. Included patients: Adults (≥18 year...

Clinical Studies - Oct 1, 2017 - Jul 1, 2021

Completed

Project leader: Engel Reto
Members: Gemperle Michaela

Beurteilung der Sicherheit und Wirksamkeit eines Edoxabanbasierten , verglichen mit einem Vitamin-K-Antagonist-basierten, antithrombotischen Therapieregimes nach einer erfolgreichen perkutanen Koronarintervention (PCI) mit Stent-Implantation, bei Pat...

Clinical Studies - Jul 7, 2017 - Jul 7, 2021

Completed

Project leader: Rickli Hans
Members: Gemperle Michaela

Explore Clinical Utility of Evolocumab in Combination with an e-Health System: Swiss Prospective Observational Study in Patients with clinical Atherosclerotic Cardiovascular Disease (ASCVD) (ECARA)

Clinical Studies - Jun 16, 2017 - Dec 1, 2019

Completed

Project leader: Rickli Hans
Members: Gemperle Michaela

A multi-center, randomized, double-blind, active-controlled, parallelgroup Phase 3 study to evaluate the efficacy and safety of LCZ696 compared to ramipril on morbidity and mortality in high risk patients following an acute myocardial infarction The...

Clinical Studies - May 31, 2017 - Mar 1, 2021

Completed

Project leader: Maeder Micha
Members: Gemperle Michaela

Nicht-interventionelle Studie zur Edoxaban-Therapie in der klinischen Routinepraxis bei Patienten mit nicht-valvulärem Vorhofflimmern (Non-interventional study on Edoxaban Treatment in routiNe clinical prActise for patients with non valvular Atrial F...

Clinical Studies - Dec 6, 2016 - Dec 15, 2021

Completed

Project leader: Ammann Peter
Members: Gemperle Michaela, Altmann David

Study Hypothesis: In patients with evidence of device-detected sub-clinical atrial fibrillation (SCAF) and additional risk factors for stroke, treatment with apixaban compared with aspirin will reduce the risk of the composite of stroke and systemic...

Clinical Studies - Apr 1, 2016 - Jan 1, 2026

Ongoing

Project leader: Ammann Peter
Members: Gemperle Michaela, Brenner Roman, Fink Karin, Vetsch Susanne

The aim of this registry is to prolong the patient observation period and recruit new patients to gain further insights into the long-term use of NOACs, including switching from Vitamin K antagonists (VKAs), to NOACs in a real life setting. This will...

Clinical Studies - Jan 15, 2015 - Mar 31, 2016

Completed

Project leader: Ammann Peter
Members: Gemperle Michaela

Ziel dieser Studie ist es, klinische Daten über die Sicherheit und Leistung von ACUITY X4®-Elektroden bei der Anwendung im klinischen Alltag zu erheben. Für die Zwecke der PMCF (Post Market Clinical Follow-up) werden die Erfolgsrate der Implantation...

Clinical Studies - Jul 28, 2014 - Nov 1, 2016

Completed

Project leader: Ammann Peter
Members: Gemperle Michaela

A multicenter, randomized, double-blind, placebocontrolled phase III study to evaluate the efficacy, safety and tolerability of Serelaxin when added to standard therapy in acute heart failure patients The purpose of this study is to evaluate the eff...

Clinical Studies - Jun 20, 2014 - Mar 22, 2017

Completed

Project leader: Maeder Micha
Members: Gall Christian, Gemperle Michaela

To increase our knowledge on structural brain damage and its changes over time in patients with AF 2. To gain additional insights on the incidence and underlying mechanisms of cognitive decline in patients with AF 3. To improve long term risk pre...

Clinical Studies - Jun 12, 2014 - Jan 1, 2032

Ongoing

Project leader: Ammann Peter
Members: Altmann David, Gemperle Michaela, Kopp Sebastian, Fink Karin, Brenner Roman, Vetsch Susanne

Double-Blind, Randomized, Multi-Center, Placebo-Controlled, Parallel Group Study to Determine the Effects of Evolocumab (AMG 145) Treatment on Atherosclerotic Disease Burden As Measured By Intravascular Ultrasound in Subjects Undergoing Coronary Cath...

Clinical Studies - Jan 9, 2014 - Jan 9, 2018

Completed

Project leader: Rickli Hans
Members: Weilenmann Daniel, Gemperle Michaela, Rigger Johannes

A Multicenter Open-label Extension (OLE) Study to Assess the Long-term Safety and Efficacy of AMG 145 Study Phase: 3 Indication: Primary hyperlipidemia and mixed dyslipidemia Primary Objective: To characterize the safety and tolerability of long-ter...

Clinical Studies - Sep 20, 2013 - Sep 20, 2017

Completed

Project leader: Rickli Hans
Members: Gemperle Michaela, Rigger Johannes

A global post-market registry of patients with de novo lesions in previously untreated vessels treated with Absorb BVS per IFU (on-label use)

Clinical Studies - Jul 10, 2013 - Oct 1, 2015

Completed

Project leader: Weilenmann Daniel
Members: Vollenbroich Rene, Gemperle Michaela

Canakinumab for the prevention of recurrences after electrical cardioversion in patients with persistent atrial fibrillation (CONVERT-AF) trial Primary objective: To determine the effect of canakinumab on atrial fibrillation (AF) recurrences withi...

Clinical Studies - Jun 20, 2013 - Jun 20, 2017

Aborted

Project leader: Ammann Peter
Members: Altmann David, Gemperle Michaela

Eine prospektive Studie zur Prognostizierbarkeit der Therapie Qualität mit Priorität auf die schmerzfreie ATP Therapie Das Ziel dieser klinischen Studie ist es, die Effektivität und die Auftretungshäufigkeit der vom ICD-Gerät (Implantierbarer Kardio...

Clinical Studies - Jan 3, 2013 - Dec 31, 2015

Completed

Project leader: Ammann Peter
Members: Altmann David, Rohner Franziska, Gemperle Michaela, Schefer Mirjam

Importance of Long-Term Follow-up of the ORIGIN Participants, the ORIGINALE (ORIGIN and Legacy Effects) Study

Clinical Studies - Nov 19, 2012 - Nov 19, 2016

Completed

Project leader: Brändle Michael
Members: Rickli Hans, Gemperle Michaela

Rechts- versus links apikale transvenöse Stimulation bei Patienten mit erhaltener links ventrikulärer systolischer Funktion, Bei Patienten die einen Herzschrittmacher benötigen wird die ventrikuläre Elektrode herkömmlicherweise apikal implantiert,...

Clinical Studies - Aug 16, 2012 - Aug 16, 2016

Aborted

Project leader: Ammann Peter
Members: Gemperle Michaela, Schefer Mirjam, Haager Philipp K.

Die Studie ist eine prospektive invasive, longitudinale Pilot Studie an hyperthyreoten Patienten mit Frage nach pulmonaler Hypertonie; 2.1 Häufigkeit der pulmonalen Hypertonie bei Patienten mit Hyperthyreose 2.1.1. Definition der pulmonalen Hyper...

Clinical Studies - Jun 1, 2012 - Dec 31, 2022

Completed

Project leader: Ammann Peter, Brändle Michael
Members: Locher Rebecca, Gemperle Michaela, Drescher Tilman, Vetsch Susanne, Schneider Irene, Brenner Roman

Europäische Multinationale Studie zur Prävention von Thromboembolien bei Vorhofflimmern DSE-EAF-01-11 Vorhofflimmern (VHF) ist die häufigste Herzrhythmusstörung im klinischen Alltag, von der ca.1-2% der allgemeinen Bevölkerung betroffen sind.1, 2 Die...

Clinical Studies - May 31, 2012 - Dec 31, 2013

Completed

Project leader: Ammann Peter
Members: Gemperle Michaela