Volker Thiel
Secretome analysis of the human airway epithelium following human respiratory virus infection
Jan 1, 2013The human airway epithelium represents the entry port of many human respiratory viruses, such as respiratory syncytial virus (RSV), influenza A viruses (IAV), and human coronaviruses (HCoV). It represents the interface between the external world and...
Fundamental Research - Jan 1, 2013 - Dec 31, 2013
Completed
Project leader: Thiel Volker
Members: Dijkman Ronald, Jonsdottir Hulda
Genetic modification of the human airway epthelium - a paradigmatic system to study host responses to human respiratory viruses
Jul 1, 2012Das menschliche Atemwegsepithelium ist die Haupteintrittspforte für viele respiratorische Viren. Obwohl primäre humane Epithelzellen in Form eines Atemwegsepitheliums, das in vieler Hinsicht den in vivo Verhältnissen entspricht, kultiviert werden kön...
Fundamental Research - Jul 1, 2012 - Dec 31, 2013
Completed
Project leader: Thiel Volker
Members: Jonsdottir Hulda, Dijkman Ronald
Genetic modification of the human airway epithelium – a paradigmatic system to study host responses to human respiratory viruses
Jan 1, 2012The goal of this project is to establish a unique experimental system to study fundamental aspects of human respiratory virus replication and interactions with the innate immune system at the natural entry port of human respiratory viruses, namely th...
Fundamental Research - Jan 1, 2012 - Dec 31, 2012
Completed
Project leader: Thiel Volker
Members: Dijkman Ronald
Mechanisms of antibody-mediated protection against virus-induced inflammatory demyelination
Jul 1, 2011Background: The epidemiology of multiple sclerosis (MS) suggests that environmental factors such as infections with coronaviruses critically determine the risk for this chronic demyelinating disease. Infection of the CNS with neurotropic mouse corona...
Fundamental Research - Jul 1, 2011 - Jun 30, 2013
Completed
Project leader: Gil Cruz Cristina, Ludewig Burkhard
Members: Thiel Volker
Impact of RNA modification on coronavirus-induced innate immune responses
Oct 1, 2010Eukaryotic messenger RNAs (mRNAs) play a universal role as transcripts of the genomic information that is used for the translation into proteins of a cell. Similarly, viruses that infect eukaryotic host cells produce viral mRNAs from their genome in...
Fundamental Research - Oct 1, 2010 - Sep 30, 2013
Completed
Project leader: Thiel Volker
Members: Kindler Eveline, Dijkman Ronald
SARS: Ökologie und Pathogenese einer archetypischen Zoonose - Identifizierung und Charakterisierung von konservierten coronaviralen Pathogenitätsfaktoren
Jul 1, 2010Zahlreiche Beispiele vor allem aus der Veterinärmedizin belegen, dass ein Wirtswechsel bei Coronaviren keine Seltenheit ist. Dementsprechend war das Auftreten des SARS Coronavirus in der humanen Population nicht wirklich überraschend, zeigte jedoch,...
Fundamental Research - Jul 1, 2010 - Jun 30, 2013
Automatically Closed
Project leader: Thiel Volker
Members: Gil Cruz Cristina
Impact of immune regulation on virus-induced chronic CNS inflammation and demyelination
Aug 1, 2009Background: Multiple sclerosis (MS) is an important disease affecting young adults. Epidemiological studies indicate that this disease critically depends on environmental factors, including infectious agents. It appears that infections with a variety...
Fundamental Research - Aug 1, 2009 - Sep 30, 2009
Completed
Project leader: Ludewig Burkhard, Thiel Volker
Members: Cervantes-Barragan Luisa, Cupovic Jovana
Reverse genetic analysis of coronavirus replication
Jan 1, 2009The reverse genetic system for the mouse hepatitis virus (MHV) in combination with a murine model for coronavirus infection allows for the use of genetically modified virus and host strains to assess the full range of virus-host interactions and to d...
Fundamental Research - Jan 1, 2009 - Dec 31, 2009
Completed
Project leader: Thiel Volker
Members: Nussbacher Monika, Züst Roland
TOLERAGE: Normalisation of immune reactivity in old age – from basic mechanisms to clinical application
Apr 1, 2008Reconstitution of normal immune function in old age is generally based on boosting the response against foreign antigens, e.g. infectious microorganisms. Our focus, however, will be to normalise immune reactivity by correcting the immune dysregulati...
Fundamental Research - Apr 1, 2008 - Sep 30, 2012
Completed
Project leader: Ludewig Burkhard, Thiel Volker
Members: Cervantes-Barragan Luisa, Eugster Karin
Entwicklung einer Coronavirus basierten Multigenvakzine zum Schutz gegen Tumorerkrankungen
Jan 1, 2008Krebszellen produzieren antigenetische Zielstrukturen, die sie für einen Angriff durch spezifische Immunzellen sensibilisieren. Die effektivste Waffe des Immunsystems gegen Tumorzellen sind zytotoxische T-Zellen. Die effiziente Aktivierung dieser Kil...
Fundamental Research - Jan 1, 2008 - Dec 31, 2009
Completed
Project leader: Ludewig Burkhard, Thiel Volker
Members: Makia Divine, Nussbacher Monika
Reverse genetic analysis of coronavirus replication
Oct 1, 2007The reverse genetic system for the mouse hepatitis virus (MHV) in combination with a murine model for coronavirus infection allows for the use of genetically modified virus and host strains to assess the full range of virus-host interactions and to d...
Fundamental Research - Oct 1, 2007 - Sep 30, 2010
Completed
Project leader: Thiel Volker
Members: Nussbacher Monika, Züst Roland
AIDS-CoVAC: Generation of a coronavirus-based multigene AIDS vaccine and evaluation in a preclinical SIV model
Dec 1, 2006Coronaviruses spread via mucosal surfaces and can infect dendritic cells. These features and their exceptional transcription strategy make them extremely promising candidate vaccine vectors to overcome known problems of current HIV vaccine approaches...
Fundamental Research - Dec 1, 2006 - May 31, 2009
Completed
Project leader: Ludewig Burkhard, Thiel Volker
Members: Eugster Karin, Cervantes-Barragan Luisa, Makia Divine
Coronavirus-based multigene HIV vaccine vectors
Jul 1, 2005The specific aim of this application is to provide the proof-of-principle that coronavirus vectors can indeed induce protective antiviral humoral and cellular immune responses in vivo. To this end, we will generate mouse hepatitis virus (MHV) vectors...
Fundamental Research - Jul 1, 2005 - Jun 30, 2007
Completed
Project leader: Thiel Volker
Members: Ludewig Burkhard
Complementary research action to support SARS-related diagnostic tests, therapeutic interventions and vaccine development – SARS-DTV
Oct 1, 2004The overall objective of the SARS-DTV network is to contribute to the development of candidate anti-SARS-CoV drugs, vaccines and diagnostic assays, by collaborative and complementary research divided into four Work packages. Molecular targets for ant...
Fundamental Research - Oct 1, 2004 - Sep 30, 2007
Completed
Project leader: Thiel Volker