Projects
Search from 1084 projects:
1084 Project(s)
Early protected full weight-bearing vs. partial weight-bearing after surgical fixation of unstable ankle fractures, monitored with bio-feedback insoles. A single blinded randomized controlled study
Sep 1, 2023adhere to instructions concerning weight-bearing. The purpose of this study is to compare the postoperative results after ORIF with a PWB protocol versus an early FWB protocol. But in addition, we will measure every patient’s actual load by the mean...
Clinical Studies - Sep 1, 2023 - Oct 31, 2026
Scheduled
Project leader: Potocnik Primoz, Toepfer Andreas
Immunopathological pathways underlying myocarditis and inflammatory cardiomyopathy – an exploratory study
Jul 24, 2023Primary objective: Analysis of cardiac antigen- and microbiota-reactive CD4+ T cell and B cell response during development of cardiac inflammation. Secondary objectives: Analysis of clinical data, cardiac imaging and immunological parameters (HLA de...
Clinical Studies - Jul 24, 2023 - Jul 24, 2024
Scheduled
Project leader: Ludewig Burkhard
Members: Vetsch Susanne, Meier Jessica
A Randomized, Open-label, Phase 3 Study of Tarlatamab Compared With Standard of Care in Subjects with Relapsed Small Cell Lung Cancer After Platinum-based First Line chemotherapy (DeLLphi-304)
Jul 17, 2023
Clinical Studies - Jul 17, 2023 - Dec 31, 2025
Ongoing
Project leader: Früh Martin
Members: Hutter Franziska, Quinter Janine
Selution DeNovo Study
Jul 15, 2023Prospective Randomized, Multi-centre, International, Open Label, Clinical trial comparing the Selution DEB strategy versus any CE-marked DES strategy. The study will test: 1) for non-inferiority of a DEB plus provisional DES treatment strategy vers...
Clinical Studies - Jul 15, 2023 - Dec 31, 2030
Scheduled
Project leader: Rigger Johannes
Members: Meier Jessica, Schneider Irene
Retrospective and prospective registry of patients with metastatic NSCLC harboring typical and atypical EGFR mutations
Jul 3, 2023
Clinical Studies - Jul 3, 2023 - Dec 31, 2030
Ongoing
Project leader: Früh Martin
Members: Radovanovic Suzana, Frehner Jan
Leptomeningeal Collaterals in INtracErebral Hemorrhage: Association with Hematoma Size and Expansion
Jul 3, 2023Die intrazerebrale Blutung (ICB) ist eine verheerende Form des Schlaganfalls, die mit einer hohen Morbidität und Mortalität einhergeht. Die Ausdehnung des Hämatoms trägt wesentlich zu den schlechten Ergebnissen bei ICB-Patienten bei und gilt als beei...
Clinical Studies - Jul 3, 2023 - Jan 1, 2025
Ongoing
Project leader: Dittrich Tolga, De Marchis Gian Marco
Members: Zell Daniel
Meaningful Patient and Public Involvement in the SHCS: A methods review and mixed-method study
Jul 1, 2023
Clinical Studies - Jul 1, 2023 - Oct 31, 2024
Ongoing
Project leader: Notter Julia
Members: Jackson-Perry David
Swiss Cardiac Amyloidosis Registry
Jul 1, 2023The aim of the Swiss-CARE registry is a comprehensive collection of clinical data and a follow-up of patients diagnosed with cardiac amyloidosis. Patients with and without therapy will be included in the registry. This will allow us to better under...
Register - Jul 1, 2023 - Jul 1, 2033
Ongoing
Project leader: Ehl Niklas
Members: Schneider Irene
Swiss Secondary Prevention and Rehabilitation Registry: SwissPR
Jul 1, 2023The rationale of this prospective longitudinal cohort study is to determine the short and long-term effects of an ambulatory cardiac rehabilitation program on key cardiovascular benchmark performance measures and its effects on major adverse cardiova...
Register - Jul 1, 2023 - Dec 31, 2040
Scheduled
Project leader: Buser Marc
Members: Schneider Irene
A Phase 1/2 Study of BMS-986408 Alone and in Combination with Nivolumab or with Nivolumab and Ipilimumab in Participants with Advanced Solid Tumors
Jun 21, 2023Das primäre Ziel dieser Studie ist die Charakterisierung des Sicherheitsprofils von BMS-986408 als Monotherapie und in Kombination mit Nivolumab oder Nivolumab und Ipilimumab, um die maximal verträgliche Dosis (MTD) zu ermitteln. Außerdem soll die em...
Clinical Studies - Jun 21, 2023 - Dec 31, 2030
Ongoing
Project leader: Jörger Markus
Members: Hutter Franziska, Frehner Jan
Oceanic AF
Jun 1, 2023A multicenter, international, randomized, active comparator-controlled, double-blind, doubledummy, parallel-group, 2-arm, Phase 3 study to compare the efficacy and safety of the oral FXIa inhibitor asundexian (BAY 2433334) with apixaban for the preve...
Clinical Studies - Jun 1, 2023 - Jun 30, 2026
Ongoing
Project leader: Rickli Hans
Members: Fink Karin, Vetsch Susanne
Impact of Tenofovir disoproxil fumarate/Emtricitabine (TDF/FTC) on the gut microbiome and microbiome-mediated toxicity of TDF/FTC in men using event-based HIV Pre- Exposure prophylaxis
Jun 1, 2023
Clinical Studies - Jun 1, 2023 - Mar 31, 2025
Ongoing
Project leader: Notter Julia
Members: Kahlert Christian
AmplatzerTM PFO Occluder and AmplatzerTM TalismanTM PFO Occluder PAS (“PFO PAS”) AmplatzerTM PFO Occluder and AmplatzerTM TalismanTM PFO Occluder Post Approval Study
Jun 1, 2023PFO PAS is a singel arm, multinational post-market study in patients with PFO after ischemic stroke (paradoxical embolism). Screening via PFO colloquium. Study Objectives; To demonstrate safety of the Amplatzer PFO Occluder and Amplatzer Talisman P...
Clinical Studies - Jun 1, 2023 - Jun 1, 2028
Ongoing
Project leader: Chronis Joannis
Members: Meier Jessica, Vetsch Susanne, Schneider Irene
Boehringer Ingelheim BI1366-0031_456906_SSc
May 22, 2023A Phase II, randomised, placebo-controlled, double-blind, parallel-group, efficacy and safety study of at least 48 weeks of oral BI 685509 treatment in adults with early progressive diffuse cutaneous systemic sclerosis
Clinical Studies - May 22, 2023 - May 22, 2026
Ongoing
Project leader: Rubbert-Roth Andrea
Members: Schmiedeberg Kristin, Bartz-Batliner Mira, Peischl Shirin, Gostic Dragana
A PHASE IB/II RANDOMIZED, OPEN LABEL DRUG REPURPOSING TRIAL OF GLUTAMATE SIGNALING INHIBITORS IN COMBINATION WITH CHEMORADIOTHERAPY IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA (GLUGLIO)
May 10, 2023Die Studie untersucht die Wirksamkeit einer Kombination der Studienmedikamente Gabapentin, Sulfasalazin und Memantin zusammen mit der Standardtherapie (Strahlentherapie und Chemotherapie mit Temozolomid). Alle drei Studienmedikamente hemmen an unters...
Clinical Studies - May 10, 2023 - Dec 31, 2030
Ongoing
Project leader: Hundsberger Thomas
Members: Harder Anja, Frehner Jan
OCEAN
May 1, 2023A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Olpasiran on Major Cardiovascular Events in Patients with Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein (a).
Clinical Studies - May 1, 2023 - Dec 31, 2024
Scheduled
Project leader: Bilz Stefan
Members: Räss Andrea, Rickli Hans, Vetsch Susanne
Studie zur Untersuchung, wie gut die Behandlung mit dem Antikörper-Konjugat Sacituzumab Govitecan wirkt bei Frauen mit frühem, HER2-negativem Brustkrebs und ho-hem Rückfallrisiko nach einer medikamentösen Vorbe-handlung und Operation im Vergleich zu schon bekannten Therapien
Apr 26, 2023Die Studie richtet sich an Personen, die an frühem HER2-negativem Brustkrebs leiden und ein hohes Rückfallrisiko nach medikamentöser Vorbehandlung und Operation aufweisen. In dieser Studie erhalten die Teilnehmenden entweder das Medikament mit dem Wi...
Clinical Studies - Apr 26, 2023 - Dec 31, 2026
Ongoing
Project leader: Huober Jens
Acceleron_A1334-02
Apr 14, 2023A Phase 1b Randomized, Double-Blind, Placebo-Controlled, Multiple-Ascending Dose Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of ACE-1334 Plus Standard of Care in Participants with Systemic Sclerosis
Clinical Studies - Apr 14, 2023 - Apr 14, 2026
Ongoing
Project leader: Rubbert-Roth Andrea
Members: Schmiedeberg Kristin, Bartz-Batliner Mira, Peischl Shirin, Gostic Dragana
Sicherheit und Wirksamkeit von ION363 bei Patienten git genetrischer ALS mit Fused in Sarcoma Mutation (FUS-ALS), Phase 1-3
Apr 3, 2023Bewertung der klinischen Wirksamkeit von ION363 in Bezug auf die klinische Funktion und das Überleben bei Patienten mit Amyotropher Lateralsklerose (ALS) und Fused-in-Sarkom-Mutationen (FUS-ALS. Weiterhin die Auswirkungen von ION363 auf die Verhind...
Clinical Studies - Apr 3, 2023 - Apr 3, 2028
Scheduled
Project leader: Neuwirth Christoph
Members: Weber Markus, Braun Nathalie
A multicentre single-arm phase II trial of amivantamab, lazertinib plus bevacizumab in patients with EGFR-mutant advanced NSCLC with progression on previous third-generation EGFR-TKI
Mar 14, 2023Die klinische Studie AMAZE-lung ist für Patienten bestimmt, bei denen eine Art von Lungenkrebs diagnostiziert wurde, der als "fortgeschrittener nicht-kleinzelliger Lungenkrebs" bezeichnet wird. Der Lungenkrebs, der in dieser Studie behandelt wird, we...
Clinical Studies - Mar 14, 2023 - Dec 31, 2030
Ongoing
Project leader: Früh Martin
Members: Harder Anja, Frehner Jan