Projects
Search from 1159 projects:
1159 Project(s)
Coronavirus-based multigene HIV vaccine vectors
Jul 1, 2005The specific aim of this application is to provide the proof-of-principle that coronavirus vectors can indeed induce protective antiviral humoral and cellular immune responses in vivo. To this end, we will generate mouse hepatitis virus (MHV) vectors...
Fundamental Research - Jul 1, 2005 - Jun 30, 2007
Completed
Project leader: Thiel Volker
Members: Ludewig Burkhard
A Phase III Trial Evaluating the Role of Exemestane Plus GnRH Analogue as Adjuvant Therapy for Premenopausal Women with Endocrine Responsive Breast Cancer
Jun 1, 2005Das antihormonelle medikamentöse Standardmedikament ist Tamoxifen. Exemestane ist ein Medikament das bei fortgeschrittenem Brustkrebsleiden bei postmenopausalen Patientinnen angewendet wird. Die Verabreichung dieses Medikaments nach operiertem Brustk...
Clinical Studies - Jun 1, 2005 - Sep 30, 2015
Completed
Project leader: Ruhstaller Thomas
Members: Baumann Michael
Neoadjuvant chemotherapy and extrapleural pneumonectomy of malignant pleural mesothelioma (MPM) with or without hemithoracic radiotherapy. A randomized multicenter phase II trial
May 31, 2005The primary objectives of this trial are to evaluate the short-term outcomes and feasibility of neoadjuvant chemotherapy and extrapleural pneumonectomy in Part 1, and long-term outcomes and feasibility of hemithoracic radiotherapy in patients with R0...
Clinical Studies - May 31, 2005 - Mar 31, 2012
Automatically Closed
Project leader: Früh Martin
Members: Neff Claudia
Trastuzumab monotherapy followed by the combination of trastuzumab and letrozole in post-menopausal women with ER-positive, HER-2 positive advanced breast cancer resistant to a nonsteroidal aromatase inhibitor
Jan 1, 2005The primary objective is to determine the efficacy of combined letrozole (L) and trastuzumab (T) in postmenopausal women with ER-positive, HER-2 positive advanced breast cancer resistant to sequential monotherapy of a nonsteroidal aromatase inhibitor...
Clinical Studies - Jan 1, 2005 - Mar 30, 2011
Automatically Closed
Project leader: Köberle Dieter
Members: Baumann Michael
Qualitätssicherungsprotokoll zur Effektivitätssteigerung in der Primärtherapie des intermediären Morbus Hodgkin (4 x ABVD + IF vs. 2 x BEACOPP eskaliert + 2 x ABVD + IF)
Dec 22, 2004Steigerung der Wirksamkeit der Therapie Primärer Endpunkt: Freedom from Treatment Failure (FFTF) Morbus Hodgkin, Erstdiagnose, therapienaiv, histologisch gesichert Alter: 18-60 Jahre Stadium IA, IB, IIA, IIB mit mindestens einem Risikofaktor
Clinical Studies - Dec 22, 2004 - Dec 22, 2012
Automatically Closed
Project leader: Hitz Felicitas
Complementary research action to support SARS-related diagnostic tests, therapeutic interventions and vaccine development – SARS-DTV
Oct 1, 2004The overall objective of the SARS-DTV network is to contribute to the development of candidate anti-SARS-CoV drugs, vaccines and diagnostic assays, by collaborative and complementary research divided into four Work packages. Molecular targets for ant...
Fundamental Research - Oct 1, 2004 - Sep 30, 2007
Completed
Project leader: Thiel Volker
Randomisierter kontrollierter Vergleich von Imatinib vs. Imatinib und Interferon-Alpha vs. Imatinib 800 mg
Sep 27, 2004Qualitätssicherungsprotokoll zur Therapieoptimierung bei chronischer myeloischer Leukämie (CML): Randomisierter kontrollierter Vergleich von Imatinib allein vs. Imatinib und Interferon-Alpha (IFN) vs. Imatinib und niedrigdosiertes AraC vs. Imatinib n...
Clinical Studies - Sep 27, 2004 - Sep 27, 2010
Automatically Closed
Project leader: Hess Urs
ORIGIN
Sep 1, 2004A Multicenter, International, Randomized, 2x2 factorial Design Study to Evaluate the Effects of Lantus (Insulin Glargine) versus Standard Care, and of Omega-3 Fatty acids versus Placebo, in reducing cardiovascular Morbidity and Mortality, People with...
Clinical Studies - Sep 1, 2004 - Sep 1, 2008
Completed
Project leader: Brändle Michael, Rickli Hans
Members: Schefer Mirjam, Maier Margarete
A randomized trial of axillary dissection versus no axillary dissection for patients with clinically node negative breast cancer and micrometastases in the sentinel node
Mar 3, 2003Axillary lymph nodes are often metastatic sites of primary breast cancer and are a major prognostic factor. No reliable non-invasive technique is available for detection of lymph node metastases. In most cases, Level I nodes (below pectoralis minor)...
Clinical Studies - Mar 3, 2003 - Feb 28, 2010
Automatically Closed
Members: Kehl Jeanine
Hepatitis C Kohorte
Sep 1, 2001Einschluss und langjährige Nachbeobachtung von Patienten mit Hepatitis C zum besseren Verständnis der Krankheit, der Verbreitung, der Uebertragungswege, dem Spontanverlauf sowie dem Krankheitsverlauf unter Therapie und deren Wirkungsmechanismen.
Clinical Studies - Sep 1, 2001 - Sep 1, 2005
Automatically Closed
Project leader: Semela David
Members: Künzler-Heule Patrizia, Weinmann Sabine
Preoperative chemoradiotherapy vs. chemotherapy alone in non-small cell lung cancer (NSCLC) patients with mediastinal lymph node metastases (stage IIIA, N2): A randomized prospective phase III trial
Aug 17, 2001The main objective of this trial is to compare feasibility and efficacy of sequential neoadjuvant chemoradiotherapy with 44 Gy concomitant boost to neoadjuvant chemotherapy alone. Secondary objectives are to assess the value of PET in predicting path...
Clinical Studies - Aug 17, 2001 - Aug 17, 2011
Automatically Closed
Project leader: Früh Martin
Members: Pfister Bogumila
Maintenance Chemotherapy in Hormone Non-Responsive Breast Cancer
Feb 1, 2001Angiogenesis, the process leading to the formation of new blood vessels, plays a central role in tumor progression of solid neoplasia. The switch from the avascular to the vascular phase is generally accompanied by rapid primary tumor growth and loca...
Clinical Studies - Feb 1, 2001 - Feb 1, 2015
Automatically Closed
Project leader: Ruhstaller Thomas
Members: Baumann Michael, Vogel Esther
Randomized phase III trial of Herceptin™ followed by Taxol plus Herceptin™ versus the combination of Herceptin™ and Taxol as palliative chemotherapy in patients with HER2-overexpressing advanced breast cancer
Nov 1, 1999To compare efficacy, toxicity and quality of life of the sequential administration of Her alone followed, at PD, by the combination with weekly Tax (Arm A) vs. the upfront combination of both drugs (Arm B) in patients with ABC.
Clinical Studies - Nov 1, 1999 - Nov 1, 2015
Automatically Closed
Project leader: Ruhstaller Thomas
Members: Baumann Michael
Autopsy study in ALS
Jan 1, 1999Death is the definitive hallmark of Amyotrophic Lateral Sclerosis (ALS) and still the primary endpoint in most treatment study. Despite its importance limited data are available about the definitive causes of death in ALS nowadays. Previous autopsy s...
Clinical Studies - Jan 1, 1999 - Jan 1, 2003
Automatically Closed
Project leader: Weber Markus
Members: Burkhardt Christian, Neuwirth Christoph
AMIS -PLUS Register
Jan 1, 1997The AMIS Plus national registry collects and analyzes data on patients with acute coronary syndrome (acute myocardial infarction, unstable angina and minimal necrosis) in Switzerland in the pre-admission, hospital and follow-up phases. Emphasis is pl...
Clinical Studies - Jan 1, 1997 - Dec 31, 2030
Ongoing
Project leader: Rickli Hans
Members: Schneider Irene, Fink Karin
Snellen-E Random-dot Stereotest
Nov 6, 1989See directions for use on http://www.torok.info/cgi-bin/stereo/dir_for_use.htm
Clinical Studies - Nov 6, 1989 - Nov 6, 2015
Automatically Closed
Project leader: Török Béla
WEB-based scoring software for the Farnsworth-Munsell 100-Hue, Roth 28-Hue, Farnsworth D-15, and the Lanthony D-15 desaturated color tests
Jun 15, 1984See directions for use on http://www.torok.info/colorvision/dir_for_use.htm
Clinical Studies - Jun 15, 1984 - Nov 6, 2015
Automatically Closed
Project leader: Török Béla
Collaborative Transplant Study
Jun 24, 1982The Collaborative Transplant Study originated from the need to gain further insight into the complex problems and risks involved in human organ transplantation. It is based on the voluntary cooperation of transplant centers from around the world. Th...
Fundamental Research - Jun 24, 1982 - Jun 24, 2015
Completed
Project leader: Binet Françoise-Isabelle
A Phase 3, Randomized, Double-blind, Active-Comparator-Controlled Clinical Study of Adjuvant MK-7684A (Vibostolimab with Pembrolizumab) Versus Adjuvant Pembrolizumab in Participants with High-risk Stage II-IV Melanoma (KEYVIBE-010)
Mar 26, 23Diese Studie soll die Wirksamkeit und Sicherheit von ei-nem experimentellen Medikament MK-7684A (Vibosto-limab zusammen mit Pembrolizumab) im Vergleich zu MK-3475 (Pembrolizumab) allein, bei Patienten mit im Stadium IIB–IV (Hochrisiko-Melanom) unters...
Clinical Studies - Mar 26, 23 - Dec 21, 2030
Ongoing
Project leader: Aeppli Stefanie
Members: Sennhauser Andrina