Project
Preoperative chemoradiotherapy vs. chemotherapy alone in non-small cell lung cancer (NSCLC) patients with mediastinal lymph node metastases (stage IIIA, N2): A randomized prospective phase III trial
Automatically Closed · 2001 until 2011
Früh Martin, Pfister Bogumila
Type
Clinical Studies
Range
Multicentric, KSSG as participating partner
Units
Status
Automatically Closed
Start Date
2001
End Date
2011
Study Design
phase III trial
Keywords
NSCLC IIIA praeoperativ, CT vs. CRT
Partner
PD Dr. med. Miklos Pless, Winterthur
Prof. Dr. Roger Stupp, Lausanne
Brief description/objective
The main objective of this trial is to compare feasibility and efficacy of sequential neoadjuvant chemoradiotherapy with 44 Gy concomitant boost to neoadjuvant chemotherapy alone. Secondary objectives are to assess the value of PET in predicting pathological response and event-free survival in stage IIIA NSCLC, and an economic
evaluation of the two regimens.