The main hypothesis underlying the suggested research program is that autoimmune CD4+ T cells cross-reacting with bacteria in the intestinal microbiome drive not only the development of acute cardiac inflammation but maintain the perpetuation of infl...

Clinical Studies - Jul 24, 2023 - Jul 24, 2024

Automatically Closed

Project leader: Ludewig Burkhard
Members: Rickli Hans, Maeder Micha, Vetsch Susanne

A multicenter, international, randomized, active comparator-controlled, double-blind, doubledummy, parallel-group, 2-arm, Phase 3 study to compare the efficacy and safety of the oral FXIa inhibitor asundexian (BAY 2433334) with apixaban for the preve...

Clinical Studies - Jun 1, 2023 - Jun 30, 2024

Completed

Project leader: Rickli Hans
Members: Fink Karin, Vetsch Susanne

A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Olpasiran on Major Cardiovascular Events in Patients with Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein (a).

Clinical Studies - May 1, 2023 - Dec 31, 2024

Aborted

Project leader: Bilz Stefan
Members: Räss Andrea, Rickli Hans, Vetsch Susanne

A Multicenter, Cross-sectional Study to Characterize the Distribution of Lipoprotein(a) Levels Among Patients With Documented History of Atherosclerotic Cardiovascular Disease (ASCVD). The purpose of the study is to characterize the distribution o...

Clinical Studies - May 1, 2022 - Mar 31, 2023

Completed

Project leader: Rickli Hans
Members: Vetsch Susanne, Bilz Stefan, Räss Andrea

To test in a multicenter open-label randomized controlled trial across Switzerland whether a cascade screening programme for FH, in comparison with usual care, will increase the detection rate of FH within families. The primary outcome will be the...

Clinical Studies - Dec 15, 2020 - Mar 31, 2024

Completed

Project leader: Rickli Hans
Members: Vetsch Susanne, Schneider Irene

The primary aim is to gather observational data from consecutive SCAD patients in Switzerland, in order to establish a National Swiss Registry (SwissSCAD). SCAD is a poorly understood condition, affecting young patients and is associated with major...

Clinical Studies - Oct 1, 2020 - Dec 31, 2030

Ongoing

Project leader: Rickli Hans
Members: Schneider Irene

Treatment patterns and Outcomes across the disease Continuum in patients with CAD and/or PAD The study aims to collect real-world data on treatment patterns and decision points for treatment in patients with coronary artery disease (CAD) or sym...

Clinical Studies - Jul 14, 2020 - Apr 14, 2023

Completed

Project leader: Rickli Hans
Members: Fink Karin

Multicenter, randomized, active comparator-controlled, double-blind, double-dummy, parallel group, dose-finding Phase 2 study to compare the safety of the oral FXIa inhibitor BAY 2433334 to apixaban in patients with atrial fibrillation Primary Safet...

Clinical Studies - Jan 21, 2020 - Dec 7, 2021

Completed

Project leader: Rickli Hans
Members: Fink Karin, Vetsch Susanne

The study aims to collect real-world data on treatment patterns and decision points for treatment in patients with coronary artery disease (CAD) or symptomatic peripheral artery disease (PAD) treated with rivaroxaban 2.5 mg[BID] for the prevention of...

Clinical Studies - Nov 19, 2019 - Dec 21, 2021

Completed

Project leader: Rickli Hans
Members: Fink Karin

A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects with Acute Coronary Syndrome

Clinical Studies - Aug 7, 2019 - Aug 30, 2020

Aborted

Project leader: Rickli Hans
Members: Vetsch Susanne

Prospektive nicht-interventionelle Studie zur optimierten Behandlung einer therapierefraktären Hypercholesterinämie bei Patienten mit heterozygoter familiärer Hypercholesterinämie oder klinisch manifester atherosklerotischer kardiovaskulärer Erkranku...

Clinical Studies - Apr 8, 2019 - Jan 15, 2021

Completed

Project leader: Rickli Hans
Members: Gemperle Michaela

Ziele: Aus den klinischen Daten (Anamnese, körperliche Untersuchung und einem der Ischämietests [Ergometrie, Stress-Echo, Stress MRI) wird mit einer logistischen Regression eine Wahrscheinlichkeits-funktion abgeleitet. Als Referenzuntersuchung gelten...

Clinical Studies - Feb 1, 2019 - Mar 31, 2022

Completed

Project leader: Rickli Hans
Members: Schneider Irene

Beurteilung der Sicherheit und Wirksamkeit eines Edoxabanbasierten , verglichen mit einem Vitamin-K-Antagonist-basierten, antithrombotischen Therapieregimes nach einer erfolgreichen perkutanen Koronarintervention (PCI) mit Stent-Implantation, bei Pat...

Clinical Studies - Jul 7, 2017 - Jul 7, 2021

Completed

Project leader: Rickli Hans
Members: Gemperle Michaela

Explore Clinical Utility of Evolocumab in Combination with an e-Health System: Swiss Prospective Observational Study in Patients with clinical Atherosclerotic Cardiovascular Disease (ASCVD) (ECARA)

Clinical Studies - Jun 16, 2017 - Dec 1, 2019

Completed

Project leader: Rickli Hans
Members: Gemperle Michaela

GLORIA-AF: Global Registry on Long-Term Oral Anti-thrombotic Treatment in Patients with Atrial Fibrillation (Phase II/III – India and Switzerland) International, multicenter, prospective observational study for patients with newly diagnosed non-valvu...

Clinical Studies - Feb 14, 2014 - Nov 30, 2019

Completed

Project leader: Rickli Hans

Double-Blind, Randomized, Multi-Center, Placebo-Controlled, Parallel Group Study to Determine the Effects of Evolocumab (AMG 145) Treatment on Atherosclerotic Disease Burden As Measured By Intravascular Ultrasound in Subjects Undergoing Coronary Cath...

Clinical Studies - Jan 9, 2014 - Jan 9, 2018

Completed

Project leader: Rickli Hans
Members: Weilenmann Daniel, Gemperle Michaela, Rigger Johannes

A Multicenter Open-label Extension (OLE) Study to Assess the Long-term Safety and Efficacy of AMG 145 Study Phase: 3 Indication: Primary hyperlipidemia and mixed dyslipidemia Primary Objective: To characterize the safety and tolerability of long-ter...

Clinical Studies - Sep 20, 2013 - Sep 20, 2017

Completed

Project leader: Rickli Hans
Members: Gemperle Michaela, Rigger Johannes

Die Behandlung von koronaren Läsionen mit PRO-Kinetic Energy Kobalt-Chrom Metall Stent (BIOHELIX II) Das primäre Ziel dieser Studie ist der Nachweis der klinischen Leistungsfähigkeit des PRO-Kinetic Energy Stents bei Patienten mit Atherosklerose in...

Clinical Studies - May 24, 2013 - May 24, 2017

Aborted

Project leader: Rickli Hans
Members: Schneider Irene

A Double-blind, Randomized, Placebo and Ezetimibe Controlled, Multicenter Study to Evaluate Safety, Tolerability and Efficacy of AMG 145 on LDL-C in Combination With Statin Therapy in Subjects With Primary Hypercholesterolemia and Mixed Dyslipidemia;

Clinical Studies - Apr 1, 2013 - Mar 3, 2014

Completed

Project leader: Rickli Hans
Members: Schefer Mirjam, Vollenbroich Rene

Importance of Long-Term Follow-up of the ORIGIN Participants, the ORIGINALE (ORIGIN and Legacy Effects) Study

Clinical Studies - Nov 19, 2012 - Nov 19, 2016

Completed

Project leader: Brändle Michael
Members: Rickli Hans, Gemperle Michaela