Publikation

Relationship Between Propofol Target Concentrations, Bispectral Index, and Patient Covariates During Anesthesia.

Wissenschaftlicher Artikel/Review - 01.03.2021

Bereiche
PubMed
DOI
Kontakt

Zitation
Schnider T, Minto C, Egan T, Filipovic M. Relationship Between Propofol Target Concentrations, Bispectral Index, and Patient Covariates During Anesthesia. Anesth Analg 2021; 132:735-742.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Anesth Analg 2021; 132
Veröffentlichungsdatum
01.03.2021
eISSN (Online)
1526-7598
Seiten
735-742
Kurzbeschreibung/Zielsetzung

Internationally, propofol is commonly titrated by target-controlled infusion (TCI) to maintain a processed electroencephalographic (EEG) parameter (eg, bispectral index [BIS]) within a specified range. The overall variability in propofol target effect-site concentrations (CeT) necessary to maintain adequate anesthesia in real-world conditions is poorly characterized, as are the patient demographic factors that contribute to this variability. This study explored these issues, hypothesizing that the variability in covariate-adjusted propofol target concentrations during BIS-controlled anesthesia would be substantial and that most of the remaining interpatient variability in drug response would be due to random effects, thus suggesting that the opportunity to improve on the Schnider model with further demographic data is limited.