Publikation
Risk Factors for the Development of Fistulae and Stenoses in Crohn Disease Patients in the Swiss Inflammatory Bowel Disease Cohort
Wissenschaftlicher Artikel/Review - 25.02.2017
Zeitz Jonas, Rogler Gerhard, Fried Michael, Sulz Michael, Vavricka Stephan R, Scharl Sylvie, Misselwitz Benjamin, Frei Pascal, Biedermann Luc, Labenz Christian, Fournier Nicolas, Scharl Michael
Bereiche
PubMed
DOI
Zitation
Art
Zeitschrift
Veröffentlichungsdatum
eISSN (Online)
Seiten
Kurzbeschreibung/Zielsetzung
Background
Fistulae and stenoses represent frequent and severe complications in patients with Crohn disease (CD). Our study aimed to identify risk factors for fistula and stenosis formation in CD patients.
Summary
We retrieved data of 1,600 CD patients from the nationwide Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS). The risk for fistulae and stenoses in relation to gender, age at diagnosis, smoking status at diagnosis, and ileal involvement at diagnosis were analyzed. In the multivariate analysis, female gender showed a lower risk for developing perianal and any fistula (risk ratio [RR] 0.721, 95% confidence interval [CI] 0.582-0.893, = 0.003 and RR 0.717, 95% CI 0.580-0.888, = 0.002, respectively), and older age at diagnosis showed a lower risk for developing perianal fistula (RR 0.661, 95% CI 0.439-0.995, = 0.047). Furthermore, ileal involvement was associated with a lower risk for perianal fistula (RR 0.713, 95% CI 0.561-0.906, = 0.006), a lower risk for any fistula (RR 0.709, 95% CI 0.558-0.901, = 0.005), and a higher risk for stenosis (RR 2.170, 95% CI 1.728-2.725, < 0.001).
Key Messages
In the nationwide SIBDCS, younger age at diagnosis and male gender were risk factors for developing perianal and nonperianal fistulae. Additionally, ileal involvement was revealed to be a potent risk factor (RR 2.170) for developing a stenosis.