Incident Hepatitis C Virus Infections in the Swiss HIV Cohort Study: Changes in Treatment Uptake and Outcomes Between 1991 and 2013

Publikation

Incident Hepatitis C Virus Infections in the Swiss HIV Cohort Study: Changes in Treatment Uptake and Outcomes Between 1991 and 2013

Wissenschaftlicher Artikel/Review - 25.03.2015

Yerly S, Metzner K, Martinez de Tejada B, Martinetti G, Ledergerber B, Kovari H, Kouyos R, Klimkait T, Keiser O, Kaiser L, Kahlert Christian, Hösli I, Hoffmann M, Hirsch H H, Hasse B, Müller N, Nadal D, Weber R, Vernazza Pietro, Trkola A, Telenti A, Tarr P, Speck R, Schüpbach J, Schöni-Affolter F, Rudin C, Rickenbach M, Regenass S, Rauch A, Pantaleo G, Nicca D, Haerry D, Günthard H, Gorgievski M, Rauch Andri, Furrer Hansjakob, Salazar-Vizcaya Luisa, Keiser Olivia, Bernasconi Enos, Schmid Patrick, Stöckle Marcel, Cavassini Matthias, Ambrosioni Juan, Fehr Jan, Metzner Karin J, Rohrbach Janine, Jaquier Marie-Eve, Schlauri Marion, Swiss HIV Cohort Study, Aubert V, Fux C A, Furrer H, Fellay J, Fehr J, Elzi L, Egger M, Dollenmaier G, Cavassini M, Calmy A, Burton-Jeangros C, Bucher H C, Böni J, Bernasconi E, Battegay M, Wandeler Gilles

Zitation

Yerly S, Metzner K, Martinez de Tejada B, Martinetti G, Ledergerber B, Kovari H, Kouyos R, Klimkait T, Keiser O, Kaiser L, Kahlert C, Hösli I, Hoffmann M, Hirsch H, Hasse B, Müller N, Nadal D, Weber R, Vernazza P, Trkola A, Telenti A, Tarr P, Speck R, Schüpbach J, Schöni-Affolter F, Rudin C, Rickenbach M, Regenass S, Rauch A, Pantaleo G, Nicca D, Haerry D, Günthard H, Gorgievski M, Rauch A, Furrer H, Salazar-Vizcaya L, Keiser O, Bernasconi E, Schmid P, Stöckle M, Cavassini M, Ambrosioni J, Fehr J, Metzner K, Rohrbach J, Jaquier M, Schlauri M, Swiss HIV Cohort Study, Aubert V, Fux C, Furrer H, Fellay J, Fehr J, Elzi L, Egger M, Dollenmaier G, Cavassini M, Calmy A, Burton-Jeangros C, Bucher H, Böni J, Bernasconi E, Battegay M, Wandeler G. Incident Hepatitis C Virus Infections in the Swiss HIV Cohort Study: Changes in Treatment Uptake and Outcomes Between 1991 and 2013. Open Forum Infect Dis 2015; 2:ofv026.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Open Forum Infect Dis 2015; 2

Veröffentlichungsdatum

25.03.2015

ISSN (Druck)

2328-8957

Seiten

ofv026

Kurzbeschreibung/Zielsetzung

Background. The hepatitis C virus (HCV) epidemic is evolving rapidly in patients infected with human immunodeficiency virus (HIV). We aimed to describe changes in treatment uptake and outcomes of incident HCV infections before and after 2006, the time-point at which major changes in HCV epidemic became apparent. Methods. We included all adults with an incident HCV infection before June 2012 in the Swiss HIV Cohort Study, a prospective nationwide representative cohort of individuals infected with HIV. We assessed the following outcomes by time period: the proportion of patients starting an HCV therapy, the proportion of treated patients achieving a sustained virological response (SVR), and the proportion of patients with persistent HCV infection during follow-up. Results. Of 193 patients with an HCV seroconversion, 106 were diagnosed before and 87 after January 2006. The proportion of men who have sex with men increased from 24% before to 85% after 2006 (P < .001). Hepatitis C virus treatment uptake increased from 33% before 2006 to 77% after 2006 (P < .001). Treatment was started during early infection in 22% of patients before and 91% after 2006 (P < .001). An SVR was achieved in 78% and 29% (P = .01) of patients treated during early and chronic HCV infection. The probability of having a detectable viral load 5 years after diagnosis was 0.67 (95% confidence interval [CI], 0.58-0.77) in the group diagnosed before 2006 and 0.24 (95% CI, 0.16-0.35) in the other group (P < .001). Conclusions. In recent years, increased uptake and earlier initiation of HCV therapy among patients with incident infections significantly reduced the proportion of patients with replicating HCV.