Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland

Publikation

Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland

Wissenschaftlicher Artikel/Review - 13.07.2020

Coste A T, Lamoth F, Sanglard D, Bachmann D, Riat A, Neofytos D, Boggian Katia, Zehnder C, Garzoni C, Goldenberger D, Khanna N, Li J, Kritikos A, Fungal Infection Network of Switzerland (FUNGINOS)

Zitation

Coste A, Lamoth F, Sanglard D, Bachmann D, Riat A, Neofytos D, Boggian K, Zehnder C, Garzoni C, Goldenberger D, Khanna N, Li J, Kritikos A, Fungal Infection Network of Switzerland (FUNGINOS). Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland. Infection 2020

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Infection 2020

Veröffentlichungsdatum

13.07.2020

eISSN (Online)

1439-0973

Kurzbeschreibung/Zielsetzung

Echinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS-mutant Candida albicans/glabrata in Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes. All patients were previously exposed to echinocandins (median 26 days; range 15-77). Five patients received initial echinocandin therapy with persistent candidemia in 4 of them. Overall mortality was 33%.