Multi-fungal sepsis and mucormycosis of the central nervous system in a patient treated with ibrutinib, a case report and review of the literature

Publikation

Multi-fungal sepsis and mucormycosis of the central nervous system in a patient treated with ibrutinib, a case report and review of the literature

Wissenschaftlicher Artikel/Review - 03.12.2019

Fehr Martin, Cathomas Gieri, Graber Anne, Markert Eva, Gaus Elisabeth, Boggian Katia

Zitation

Fehr M, Cathomas G, Graber A, Markert E, Gaus E, Boggian K. Multi-fungal sepsis and mucormycosis of the central nervous system in a patient treated with ibrutinib, a case report and review of the literature. Med Mycol Case Rep 2019; 27:14-16.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Med Mycol Case Rep 2019; 27

Veröffentlichungsdatum

03.12.2019

ISSN (Druck)

2211-7539

Seiten

14-16

Kurzbeschreibung/Zielsetzung

We report the case of a 71 years old patient with chronic lymphocytic leukemia (CLL), who developed a rapidly progressing multi-fungal infection including mucormycosis of the central nervous system (CNS) during treatment with ibrutinib. On autopsy mucorales species were demonstrated intravascularly by histomorphology of several organs and lymph nodes and were characterized as by polymerase-chain reaction (PCR) - analysis. In addition, invasive pulmonary was found and also confirmed by PCR. To the best of our knowledge, this is the first confirmation of a multi-fungal sepsis and invasive CNS-infection with mucorales species under ibrutinib. Knowing the risk for invasive fungal disease in patients under ibrutinib, identifying the pathogen and early initiation of specific treatment is crucial for a good clinical outcome especially in mucormycosis.