Publikation
High prevalence of side population in human cancer cell lines
Wissenschaftlicher Artikel/Review - 10.04.2016
Bösch Maximilian, Zeimet Alain G, Fiegl Heidi, Wolf Barbara, Huber Julia, Klocker Helmut, Gastl Guenther, Sopper Sieghart, Wolf Dominik
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Cancer cell lines are essential platforms for performing cancer research on human cells. We here demonstrate that, across tumor entities, human cancer cell lines harbor minority populations of putative stem-like cells, molecularly defined by dye extrusion resulting in the side population phenotype. These findings establish a heterogeneous nature of human cancer cell lines and argue for their stem cell origin. This should be considered when interpreting research involving these model systems.