Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma.

Publikation

Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma.

Wissenschaftlicher Artikel/Review - 06.09.2018

Plath Michaela, Broglie Martina A, Förbs Diana, Stoeckli Sandro J, Jochum Wolfram

Zitation

Plath M, Broglie M, Förbs D, Stoeckli S, Jochum W. Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma. J Otolaryngol Head Neck Surg 2018; 47:53.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

J Otolaryngol Head Neck Surg 2018; 47

Veröffentlichungsdatum

06.09.2018

eISSN (Online)

1916-0216

Seiten

Kurzbeschreibung/Zielsetzung

Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) has an improved outcome and may allow for treatment de-escalation. High-risk HPV (HR-HPV) infection is associated with deregulated expression of the cell cycle-associated proteins p16, pRB, cyclin D1 and p53. The objective of this study was to assess cell cycle proteins as potential surrogate markers for HR-HPV DNA testing to identify OPSCC with favorable prognosis after resection.