Publikation

Attraction of phagocytes by apoptotic cells is mediated by lysophosphatidylcholine

Wissenschaftlicher Artikel/Review - 01.06.2007

Bereiche
PubMed
DOI

Zitation
Müller R, Sheriff A, Gaipl U, Wesselborg S, Lauber K. Attraction of phagocytes by apoptotic cells is mediated by lysophosphatidylcholine. Autoimmunity 2007; 40:342-4.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Autoimmunity 2007; 40
Veröffentlichungsdatum
01.06.2007
ISSN (Druck)
0891-6934
Seiten
342-4
Kurzbeschreibung/Zielsetzung

Apoptotic cells promote the phagocytosis of themselves via the exposure of "eat me" signals. Furthermore, a second, "find me" signal is required to attract phagocytes. In this review the double function of lysophosphatidylcholine for the clearance of apoptotic material as factor leading to attraction of phagocytes as a soluble "find me" signal and opsonisation of apoptotic cells as a membrane bound "eat me" signal is outlined. Lysophosphatidylcholine, exerting this bivalent function, leads to a sufficient clearance of apoptotic cell as a "keep calm" mechanism to prevent activation of the immune system by secondary necrosis.