Publikation

Functional lesional neurosurgery for tremor: back to the future?

Wissenschaftlicher Artikel/Review - 21.12.2017

Bereiche
PubMed
DOI
Kontakt

Zitation
Schreglmann S, Krauss J, Chang J, Martin E, Werner B, Bauer R, Hägele-Link S, Bhatia K, Kägi G. Functional lesional neurosurgery for tremor: back to the future?. J Neurol Neurosurg Psychiatry 2017; 89:727-735.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
J Neurol Neurosurg Psychiatry 2017; 89
Veröffentlichungsdatum
21.12.2017
eISSN (Online)
1468-330X
Seiten
727-735
Kurzbeschreibung/Zielsetzung

For nearly a century, functional neurosurgery has been applied in the treatment of tremor. While deep brain stimulation has been in the focus of academic interest in recent years, the establishment of incisionless technology, such as MRI-guided high-intensity focused ultrasound, has again stirred interest in lesional approaches.In this article, we will discuss the historical development of surgical technique and targets, as well as the technological state-of-the-art of conventional and incisionless interventions for tremor due to Parkinson's disease, essential and dystonic tremor and tremor related to multiple sclerosis (MS) and midbrain lesions. We will also summarise technique-inherent advantages of each technology and compare their lesion characteristics. From this, we identify gaps in the current literature and derive future directions for functional lesional neurosurgery, in particularly potential trial designs, alternative targets and the unsolved problem of bilateral lesional treatment. The results of a systematic review and meta-analysis of the consistency, efficacy and side effect rate of lesional treatments for tremor are presented separately alongside this article.