Publikation
Standard and experimental therapy in cutaneous T-cell lymphomas
Wissenschaftlicher Artikel/Review - 01.02.2006
Dummer Reinhard, Cozzio Antonio, Meier Sibylle, Beyeler Mirjam, Laetsch Barbara, Doebbeling Udo, Urosevic Mirjana
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Cutaneous T-cell lymphomas are a heterogeneous group of lymphoproliferative disorders, characterized by the accumulation of clonal lymphocytes in the skin. Skin-directed therapies are the preferred first-line modalities. There are interesting new developments in topical therapy using retinoids and gene-therapy products such as adenovirus- interferon (IFN)-gamma. Systemic treatment uses biologicals such as fusion molecules, monoclonal antibodies and immune response modifiers (IFNs and retinoids), and well-tolerated antiproliferative drugs such as methotrexate. Evidence-based treatment recommendation exists but is hampered by the lack of large multicenter randomized trials.