Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies

Publikation

Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies

Wissenschaftlicher Artikel/Review - 23.01.2013

Nettleton Jennifer A, Cupples L Adrienne, Borecki Ingrid B, Franco Oscar H, Mukamal Kenneth, Mikkilä Vera, McCarthy Mark I, Lind Lars, Hofman Albert, Groves Christopher J, Viikari Jorma, Uitterlinden André G, Syvänen Ann-Christine, Dedoussis George V, Ferrucci Luigi, Hu Frank B, McKeown Nicola M, Meigs James B, Franks Paul W, Witteman Jacqueline C M, Siscovick David S, Rotter Jerome I, Prokopenko Inga, Orho-Melander Marju, Kritchevsky Stephen B, Kao W H Linda, Kähönen Mika, Ingelsson Erik, Papoutsakis Constantina, Mozaffarian Dariush, Liu Yongmei, North Kari E, Manichaikul Ani, Lemaitre Rozenn N, Lehtimäki Terho, Kanoni Stavroula, Jacques Paul F, Houston Denise K, Hallmans Göran, Ganna Andrea, Wojczynski Mary K, Renström Frida, Ngwa Julius S, Ntalla Ioanna, Sonestedt Emily, Tanaka Toshiko, Hassanali Neelam, Zillikens M Carola, Yannakoulia Mary, Riserus Ulf, Raitakari Olli T, Pankow James S, Lohman Kurt K, Johansson Ingegerd, Grigoriou Efi, Djoussé Luc, Bandinelli Stefania, van Rooij Frank J A, Hruby Adela

Zitation

Nettleton J, Cupples L, Borecki I, Franco O, Mukamal K, Mikkilä V, McCarthy M, Lind L, Hofman A, Groves C, Viikari J, Uitterlinden A, Syvänen A, Dedoussis G, Ferrucci L, Hu F, McKeown N, Meigs J, Franks P, Witteman J, Siscovick D, Rotter J, Prokopenko I, Orho-Melander M, Kritchevsky S, Kao W, Kähönen M, Ingelsson E, Papoutsakis C, Mozaffarian D, Liu Y, North K, Manichaikul A, Lemaitre R, Lehtimäki T, Kanoni S, Jacques P, Houston D, Hallmans G, Ganna A, Wojczynski M, Renström F, Ngwa J, Ntalla I, Sonestedt E, Tanaka T, Hassanali N, Zillikens M, Yannakoulia M, Riserus U, Raitakari O, Pankow J, Lohman K, Johansson I, Grigoriou E, Djoussé L, Bandinelli S, van Rooij F, Hruby A. Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies. J Nutr 2013; 143:345-53.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

J Nutr 2013; 143

Veröffentlichungsdatum

23.01.2013

eISSN (Online)

1541-6100

Seiten

345-53

Kurzbeschreibung/Zielsetzung

Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesium intake and fasting glucose and insulin. Fifteen studies from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided data from up to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (ln-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [β = -0.009 mmol/L (95% CI: -0.013, -0.005), P < 0.0001] and insulin [-0.020 ln-pmol/L (95% CI: -0.024, -0.017), P < 0.0001]. No magnesium-related SNP or interaction between any SNP and magnesium reached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P = 0.03) with glucose, and rs11558471 in SLC30A8 and rs3740393 near CNNM2 showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted.