Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults - Publikation

Publikation

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

Wissenschaftlicher Artikel/Review - 27.04.2017

Uitterlinden André G, Thuillier Dorothée, Thorand Barbara, Tan Sian-Tsung, Tammelin Tuija, Swift Amy J, Sternfeld Barbara, Stančáková Alena, Snieder Harold, Smith Jennifer A, Smith Blair H, Silbernagel Günther, Sidney Steve, Shuldiner Alan R, Sanna Serena, Scott William R, Vandenput Liesbeth, Vestergaard Henrik, van Vliet-Ostaptchouk Jana V, Rivadeneira Fernando, Hofman Albert, Ohlsson Claes, Gyllensten Ulf, Lemarchand Loic, Haiman Christopher A, Zubair Niha, Zillikens M Carola, Wright Alan F, Wong Andrew, Wild Sarah, Walker Mark, Waeber Gerard, Völker Uwe, Vohl Marie-Claude, Savonen Kai, Sarzynski Mark A, Olden Matthias, Oldehinkel Albertine J, Nolte Ilja M, Nettleton Jennifer A, Nauck Matthias, Narisu Narisu, Männistö Satu, Männikkö Reija, Musk A W, Müller-Nurasyid Martina, Mulas Antonella, De Moor Marleen H M, Montgomery Grant W, Monda Keri L, Milaneschi Yuri, Ong Ken K, Padmanabhan Sandosh, Paternoster Lavinia, Sarti Cinzia, Rudan Igor, Rose Lynda M, Ridker Paul M, Rawal Rajesh, Rasmussen-Torvik Laura J, Rankinen Tuomo, Raitakari Olli T, Puolijoki Hannu, Prokopenko Inga, Peyser Patricia A, Peters Ulrike, Peters Annette, Perola Markus, Perez Jeremiah, Marre Michel, Pérusse Louis, Kilpeläinen Tuomas O, Barroso Inês, Abecasis Gonçalo R, Chasman Daniel I, Boerwinkle Eric, Porteous David J, Weir David R, Langenberg Claudia, Wareham Nicholas J, Metspalu Andres, Pedersen Oluf, Hansen Torben, Hallmans Göran, Vollenweider Peter, Kooperberg Charles, McCarthy Mark I, Frayling Timothy M, O'Connell Jeffrey R, Loos Ruth J F, Cupples L Adrienne, North Kari E, Franks Paul W, Borecki Ingrid B, Johnson Andrew D, Klein Robert J, Hirschhorn Joel N, Liu Ching-Ti, Fox Caroline S, Strachan David P, Mohlke Karen L, Heid Iris M, Boehnke Michael, van Duijn Cornelia M, Froguel Philippe, Kooner Jaspal S, de Geus Eco J C, Penninx Brenda W J H, Salomaa Veikko, Tuomilehto Jaakko, Sørensen Thorkild I A, Rauramaa Rainer, Kardia Sharon L R, Palmer Lyle J, Bandinelli Stefania, Tönjes Anke, Hartman Catharina A, Hveem Kristian, Cucca Francesco, Polasek Ozren, Hayward Caroline, Boomsma Dorret I, Lehtimäki Terho, Mangino Massimo, Chambers John C, Jarvelin Marjo-Riitta, Qi Lu, Völzke Henry, Gudnason Vilmundur, Harris Tamara B, Kivimäki Mika, Strauch Konstantin, März Winfried, Linneberg Allan, Liu Yongmei, Kuh Diana, Martin Nicholas G, Bouchard Claude, Laakso Markku, Wilson James F, Cheng Yu-Ching, Wu Ying, Peyrot Wouter J, Willemsen Gonneke, Huppertz Charlotte, Lyytikäinen Leo-Pekka, Stringham Heather M, Zhao Jing Hua, Whitfield John B, Rivera Natalia V, Lohman Kurt, Hollensted Mette, Kleber Marcus E, Justesen Johanne Marie, Harder Marie Neergaard, Kumari Meena, Kristiansson Kati, Demirkan Ayse, Fornage Myriam, Snitker Søren, Johansson Åsa, Pasko Dorota, Bellis Claire, Navarro Pau, Marten Jonathan, Vitart Veronique, Bragg-Gresham Jennifer L, Jackson Anne U, van der Most Peter J, Mägi Reedik, Tanaka Toshiko, Cadby Gemma, Bielak Lawrence F, Hassinen Maija, Smith Albert Vernon, Teumer Alexander, Qi Qibin, Ahluwalia Tarunveer S, den Hoed Marcel, Heard-Costa Nancy L, Workalemahu Tsegaselassie, Xue Luting, Hadley David, Mahajan Anubha, Chu Audrey Y, Winkler Thomas W, Barata Llilda, Feitosa Mary F, Young Kristin L, Justice Anne E, Scott Robert A, Ngwa Julius S, Renström Frida, Quaye Lydia, Yengo Loic, Bien Stephanie, Marques-Vidal Pedro M, Ahmad Shafqat, Haller Toomas, Griffin Paula J, Zhao Wei, Zhang Weihua, Huffman Jennifer E, Luan Jian'an, Lim Elise, Kutalik Zoltán, Cornelis Marilyn, Hayes James E, Eicher John D, Graff Mariaelisa, Eriksson Joel, Luben Robert, Hui Jennie, Huang Tao, Huang Jie, Hottenga Jouke Jan, Holzapfel Christina, Holmens Oddgeir L, Hocking Lynne J, Hindorff Lucia, Hernandez Dena, Havulinna Aki S, Hastie Nicholas D, Harald Kennet, van Grootheest Gerard, Grarup Niels, Grammer Tanja B, Huth Cornelia, Hutri-Kähönen Nina, James Alan L, Lorentzon Mattias, Lindgren Cecilia M, Lehne Benjamin, Launer Lenore J, Lakka Timo A, Kähönen Mika, Kvaløy Kirsti, Kuusisto Johanna, Komulainen Pirjo, Kolcic Ivana, Koistinen Heikki A, Kinnunen Leena, Juonala Markus, Jhun Min A, Jansson John-Olov, Grallert Harald, Gordon-Larsen Penny, Busonero Fabio, Brage Søren, Borja Judith B, Bonnycastle Lori L, Bonnefond Amélie, Blangero John, Bertoni Alain G, Bergmann Sven, Bergman Richard N, Beilby John, Auvinen Juha, Balkau Beverley, Amin Najaf, Adair Linda S, Aadahl Mette, Buyske Steve, Campbell Harry, Chines Peter S, Gong Jian, Gläser Sven, Gieger Christian, Færch Kristine, Fu Mao, Faul Jessica D, Esko Tõnu, Eiriksdottir Gudny, Ebeling Tapani, Dörr Marcus, Dueker Nicole, Delgado Graciela E, Smith George Davey, Corre Tanguy, Collins Francis S, Lim Unhee

Zitation

Uitterlinden A, Thuillier D, Thorand B, Tan S, Tammelin T, Swift A, Sternfeld B, Stančáková A, Snieder H, Smith J, Smith B, Silbernagel G, Sidney S, Shuldiner A, Sanna S, Scott W, Vandenput L, Vestergaard H, van Vliet-Ostaptchouk J, Rivadeneira F, Hofman A, Ohlsson C, Gyllensten U, Lemarchand L, Haiman C, Zubair N, Zillikens M, Wright A, Wong A, Wild S, Walker M, Waeber G, Völker U, Vohl M, Savonen K, Sarzynski M, Olden M, Oldehinkel A, Nolte I, Nettleton J, Nauck M, Narisu N, Männistö S, Männikkö R, Musk A, Müller-Nurasyid M, Mulas A, De Moor M, Montgomery G, Monda K, Milaneschi Y, Ong K, Padmanabhan S, Paternoster L, Sarti C, Rudan I, Rose L, Ridker P, Rawal R, Rasmussen-Torvik L, Rankinen T, Raitakari O, Puolijoki H, Prokopenko I, Peyser P, Peters U, Peters A, Perola M, Perez J, Marre M, Pérusse L, Kilpeläinen T, Barroso I, Abecasis G, Chasman D, Boerwinkle E, Porteous D, Weir D, Langenberg C, Wareham N, Metspalu A, Pedersen O, Hansen T, Hallmans G, Vollenweider P, Kooperberg C, McCarthy M, Frayling T, O'Connell J, Loos R, Cupples L, North K, Franks P, Borecki I, Johnson A, Klein R, Hirschhorn J, Liu C, Fox C, Strachan D, Mohlke K, Heid I, Boehnke M, van Duijn C, Froguel P, Kooner J, de Geus E, Penninx B, Salomaa V, Tuomilehto J, Sørensen T, Rauramaa R, Kardia S, Palmer L, Bandinelli S, Tönjes A, Hartman C, Hveem K, Cucca F, Polasek O, Hayward C, Boomsma D, Lehtimäki T, Mangino M, Chambers J, Jarvelin M, Qi L, Völzke H, Gudnason V, Harris T, Kivimäki M, Strauch K, März W, Linneberg A, Liu Y, Kuh D, Martin N, Bouchard C, Laakso M, Wilson J, Cheng Y, Wu Y, Peyrot W, Willemsen G, Huppertz C, Lyytikäinen L, Stringham H, Zhao J, Whitfield J, Rivera N, Lohman K, Hollensted M, Kleber M, Justesen J, Harder M, Kumari M, Kristiansson K, Demirkan A, Fornage M, Snitker S, Johansson Å, Pasko D, Bellis C, Navarro P, Marten J, Vitart V, Bragg-Gresham J, Jackson A, van der Most P, Mägi R, Tanaka T, Cadby G, Bielak L, Hassinen M, Smith A, Teumer A, Qi Q, Ahluwalia T, den Hoed M, Heard-Costa N, Workalemahu T, Xue L, Hadley D, Mahajan A, Chu A, Winkler T, Barata L, Feitosa M, Young K, Justice A, Scott R, Ngwa J, Renström F, Quaye L, Yengo L, Bien S, Marques-Vidal P, Ahmad S, Haller T, Griffin P, Zhao W, Zhang W, Huffman J, Luan J, Lim E, Kutalik Z, Cornelis M, Hayes J, Eicher J, Graff M, Eriksson J, Luben R, Hui J, Huang T, Huang J, Hottenga J, Holzapfel C, Holmens O, Hocking L, Hindorff L, Hernandez D, Havulinna A, Hastie N, Harald K, van Grootheest G, Grarup N, Grammer T, Huth C, Hutri-Kähönen N, James A, Lorentzon M, Lindgren C, Lehne B, Launer L, Lakka T, Kähönen M, Kvaløy K, Kuusisto J, Komulainen P, Kolcic I, Koistinen H, Kinnunen L, Juonala M, Jhun M, Jansson J, Grallert H, Gordon-Larsen P, Busonero F, Brage S, Borja J, Bonnycastle L, Bonnefond A, Blangero J, Bertoni A, Bergmann S, Bergman R, Beilby J, Auvinen J, Balkau B, Amin N, Adair L, Aadahl M, Buyske S, Campbell H, Chines P, Gong J, Gläser S, Gieger C, Færch K, Fu M, Faul J, Esko T, Eiriksdottir G, Ebeling T, Dörr M, Dueker N, Delgado G, Smith G, Corre T, Collins F, Lim U. Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet 2017; 13:e1006528.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

PLoS Genet 2017; 13

Veröffentlichungsdatum

27.04.2017

eISSN (Online)

1553-7404

Seiten

e1006528

Kurzbeschreibung/Zielsetzung

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.