No Impact of Body Mass Index on Outcome in Stroke Patients Treated with IV Thrombolysis BMI and IV Thrombolysis Outcome

Publikation

No Impact of Body Mass Index on Outcome in Stroke Patients Treated with IV Thrombolysis BMI and IV Thrombolysis Outcome

Wissenschaftlicher Artikel/Review - 11.10.2016

Branscheidt Meret, Luft Andreas, Wegener Susanne, Held Ulrike, Wertli Maria, Arnold Marcel, Jung Simon, Fischer Urs, Stark Robert, Kägi Georg, Eskioglou Elissavet, Michel Patrik, Schneider Juliane, Sarikaya Hakan

Zitation

Branscheidt M, Luft A, Wegener S, Held U, Wertli M, Arnold M, Jung S, Fischer U, Stark R, Kägi G, Eskioglou E, Michel P, Schneider J, Sarikaya H. No Impact of Body Mass Index on Outcome in Stroke Patients Treated with IV Thrombolysis BMI and IV Thrombolysis Outcome. PloS one 2016; 11:e0164413.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

PloS one 2016; 11

Veröffentlichungsdatum

11.10.2016

eISSN (Online)

1932-6203

Seiten

e0164413

Kurzbeschreibung/Zielsetzung

BACKGROUND AND PURPOSE
The impact of excess body weight on prognosis after stroke is controversial. Many studies report higher survival rates in obese patients ("obesity paradox"). Recently, obesity has been linked to worse outcomes after intravenous (IV) thrombolysis, but the number and sample size of these studies were small. Here, we aimed to assess the relationship between body weight and stroke outcome after IV thrombolysis in a large cohort study.

METHODS
In a prospective observational multicenter study, we analyzed baseline and outcome data of 896 ischemic stroke patients who underwent IV thrombolysis. Patients were categorized according to body mass index (BMI) as underweight (<18.5 kg/m2), normal weight (18.5-24.9 kg/m2), overweight (25-29.9 kg/m2), obese (30-34.9 kg/m2) or severely obese (>35 kg/m2). Using uni- and multivariate modeling, we assessed the relationship of BMI with favorable outcome (defined as modified Rankin Scale 0 or 1) and mortality 3 months after stroke as well as the occurrence of symptomatic intracerebral hemorrhages (sICH). We also measured the incidence of patients that had an early neurological improvement of >40% on the National Institutes of Health Stroke Scale (NIHSS) after 24 hours.

RESULTS
Among 896 patients, 321 were normal weight (35.8%), 22 underweight (2.5%), 378 overweight (42.2%), 123 obese (13.7%) and 52 severely obese (5.8%). Three-month mortality was comparable in obese vs. non-obese patients (8.1% vs. 8.3%) and did not differ significantly among different BMI groups. This was also true for favorable clinical outcome, risk of sICH and early neurological improvement on NIHSS at 24 hours. These results remained unchanged after adjusting for potential confounding factors in the multivariate analyses.

CONCLUSION
BMI was not related to clinical outcomes in stroke patients treated with IVT. Our data suggest that the current weight-adapted dosage scheme of IV alteplase is appropriate for different body weight groups, and challenge the existence of the obesity paradox after stroke.