CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance

Publikation

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance

Wissenschaftlicher Artikel/Review - 14.01.2005

Niess Jan Hendrik, Littman Dan R, Fox James G, Ploegh Hidde L, Boes Marianne, Vyas Jatin M, McCormick Beth A, Jung Steffen, Landsman Limor, Gu Xiubin, Brand Stephan, Reinecker Hans-Christian

Zitation

Niess J, Littman D, Fox J, Ploegh H, Boes M, Vyas J, McCormick B, Jung S, Landsman L, Gu X, Brand S, Reinecker H. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 2005; 307:254-8.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Science 2005; 307

Veröffentlichungsdatum

14.01.2005

eISSN (Online)

1095-9203

Seiten

254-8

Kurzbeschreibung/Zielsetzung

Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chemokine receptor CX3CR1 to form transepithelial dendrites, which enable the cells to directly sample luminal antigens. CX3CR1 was also found to control the clearance of entero-invasive pathogens by DCs. Thus, CX3CR1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.