Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection

Publikation

Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection

Wissenschaftlicher Artikel/Review - 04.08.2015

Ringel Florian, Simon Matthias, Meyer Bernhard, Schucht Philippe, Senft Christian, Westermaier Thomas, Weyerbrock Astrid, Misch Martin, Bock Hans Christoph, Krex Dietmar, Sabel Michael, Pape Haiko

Zitation

Ringel F, Simon M, Meyer B, Schucht P, Senft C, Westermaier T, Weyerbrock A, Misch M, Bock H, Krex D, Sabel M, Pape H. Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection. Neuro-oncology 2015; 18:96-104.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Neuro-oncology 2015; 18

Veröffentlichungsdatum

04.08.2015

eISSN (Online)

1523-5866

Seiten

96-104

Kurzbeschreibung/Zielsetzung

BACKGROUND
While standards for the treatment of newly diagnosed glioblastomas exist, therapeutic regimens for tumor recurrence remain mostly individualized. The role of a surgical resection of recurrent glioblastomas remains largely unclear at present. This study aimed to assess the effect of repeated resection of recurrent glioblastomas on patient survival.

METHODS
In a multicenter retrospective-design study, patients with primary glioblastomas undergoing repeat resections for recurrent tumors were evaluated for factors affecting survival. Age, Karnofsky performance status (KPS), extent of resection (EOR), tumor location, and complications were assessed.

RESULTS
Five hundred and three patients (initially diagnosed between 2006 and 2010) undergoing resections for recurrent glioblastoma at 20 institutions were included in the study. The patients' median overall survival after initial diagnosis was 25.0 months and 11.9 months after first re-resection. The following parameters were found to influence survival significantly after first re-resection: preoperative and postoperative KPS, EOR of first re-resection, and chemotherapy after first re-resection. The rate of permanent new deficits after first re-resection was 8%.

CONCLUSION
The present study supports the view that surgical resections of recurrent glioblastomas may help to prolong patient survival at an acceptable complication rate.