Publikation
Skin protection for photosensitized patients
Wissenschaftlicher Artikel/Review - 02.09.2001
Hornung René, Schwarz Viola A., Klein Sabine D., Knochenmuss Richard, Wyss Pius, Fink Daniel, Haller Urs, Walt Heinrich
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Schlagwörter (Tags)
cover cream;
human keratinocytes;
m-THPC, PDT;
sunscreen;
titan dioxide;
zinc oxide
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Kurzbeschreibung/Zielsetzung
The goal of this study was to evaluate various creams for their capability to protect photosensitized skin from visible light.
Study Design/Materials and Methods
Two cover creams and creams containing various combinations of Vaseline with TiO2, ZnO, and Fe2O3 were used to measure the reduced light transmission and the light absorption spectrum. In vitro and in vivo tests were performed to assess the protection from light by above mentioned compounds.
Results
The cover creams and the 50% TiO2 cream showed similar efficacy in reducing light transmission, while the sunscreen was less efficient by a factor of 5. Cell protection by 25% TiO2+25% ZnO, TiO2, or the cover creams was more efficient than protection by the sunscreen or other compounds. In vivo, the dark cover cream protected the skin by a factor of 3.4 better than the sunscreen.
Conclusions
The dark cover cream has acceptable properties to protect photosensitized skin. Lasers Surg. Med. 29:252–259, 2001. © 2001 Wiley-Liss, Inc.