Publikation

Immunological biomarkers predict HIV-1 viral rebound after treatment interruption

Wissenschaftlicher Artikel/Review - 09.10.2015

Bereiche
PubMed
DOI

Zitation
Hurst J, Kinloch S, Cooper D, Schechter M, Tambussi G, Fidler S, Babiker A, Weber J, Kelleher A, Phillips R, Fisher M, Brown H, Hoffmann M, Pace M, Williams J, Thornhill J, Hamlyn E, Meyerowitz J, Willberg C, Koelsch K, Robinson N, Frater J. Immunological biomarkers predict HIV-1 viral rebound after treatment interruption. Nat Commun 2015; 6:8495.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Nat Commun 2015; 6
Veröffentlichungsdatum
09.10.2015
eISSN (Online)
2041-1723
Seiten
8495
Kurzbeschreibung/Zielsetzung

Treatment of HIV-1 infection with antiretroviral therapy (ART) in the weeks following transmission may induce a state of 'post-treatment control' (PTC) in some patients, in whom viraemia remains undetectable when ART is stopped. Explaining PTC could help our understanding of the processes that maintain viral persistence. Here we show that immunological biomarkers can predict time to viral rebound after stopping ART by analysing data from a randomized study of primary HIV-1 infection incorporating a treatment interruption (TI) after 48 weeks of ART (the SPARTAC trial). T-cell exhaustion markers PD-1, Tim-3 and Lag-3 measured prior to ART strongly predict time to the return of viraemia. These data indicate that T-cell exhaustion markers may identify those latently infected cells with a higher proclivity to viral transcription. Our results may open new avenues for understanding the mechanisms underlying PTC, and eventually HIV-1 eradication.