Publikation
Immunological biomarkers predict HIV-1 viral rebound after treatment interruption
Wissenschaftlicher Artikel/Review - 09.10.2015
Hurst Jacob, Kinloch Sabine, Cooper David A, Schechter Mauro, Tambussi Giuseppe, Fidler Sarah, Babiker Abdel, Weber Jonathan, Kelleher Anthony D, Phillips Rodney E, Fisher Martin, Brown Helen, Hoffmann Matthias, Pace Matthew, Williams James P, Thornhill John, Hamlyn Elizabeth, Meyerowitz Jodi, Willberg Chris, Koelsch Kersten K, Robinson Nicola, Frater John
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PubMed
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Kurzbeschreibung/Zielsetzung
Treatment of HIV-1 infection with antiretroviral therapy (ART) in the weeks following transmission may induce a state of 'post-treatment control' (PTC) in some patients, in whom viraemia remains undetectable when ART is stopped. Explaining PTC could help our understanding of the processes that maintain viral persistence. Here we show that immunological biomarkers can predict time to viral rebound after stopping ART by analysing data from a randomized study of primary HIV-1 infection incorporating a treatment interruption (TI) after 48 weeks of ART (the SPARTAC trial). T-cell exhaustion markers PD-1, Tim-3 and Lag-3 measured prior to ART strongly predict time to the return of viraemia. These data indicate that T-cell exhaustion markers may identify those latently infected cells with a higher proclivity to viral transcription. Our results may open new avenues for understanding the mechanisms underlying PTC, and eventually HIV-1 eradication.