Publikation
Clinical significance of the CCR5delta32 allele in hepatitis C
Wissenschaftlicher Artikel/Review - 05.09.2014
Morard Isabelle, Negro Franco, Bochud Pierre-Yves, Pascarella Stéphanie, Semela David, Mullhaupt Beat, Moradpour Darius, Malinverni Raffaele, Heim Markus, Gorgievski Meri, De Gottardi Andrea, Cerny Andrea, Mangia Alessandra, Calmy Alexandra, Clément Sophie, Swiss Hepatitis C Cohort Study Group
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BACKGROUND
The CCR5 receptor, expressed on Th1 cells, may influence clinical outcomes of HCV infection. We explored a possible link between a CCR5 32-base deletion (CCR5delta32), resulting in the expression of a non-functioning receptor, and clinical outcomes of HCV infection.
METHODS
CCR5 and HCV-related phenotypes were analysed in 1,290 chronically infected patients and 160 patients with spontaneous clearance.
RESULTS
Carriage of the CCR5delta32 allele was observed in 11% of spontaneous clearers compared to 17% of chronically infected patients (OR = 0.59, 95% CI interval 0.35-0.99, P = 0.047). Carriage of this allele also tended to be observed more frequently among patients with liver inflammation (19%) compared to those without inflammation (15%, OR = 1.38, 95% CI interval 0.99-1.95, P = 0.06). The CCR5delta32 was not associated with sustained virological response (P = 0.6), fibrosis stage (P = 0.8), or fibrosis progression rate (P = 0.4).
CONCLUSIONS
The CCR5delta32 allele appears to be associated with a decreased rate of spontaneous HCV eradication, but not with hepatitis progression or response to antiviral therapy.