Publikation

Retreatment of men with metastatic castrate-resistant prostate cancer with abiraterone

Wissenschaftlicher Artikel/Review - 11.08.2014

Bereiche
PubMed
DOI

Zitation
Leibowitz-Amit R, Alimohamed N, Vera-Badillo F, Seah J, Templeton A, Knox J, Tannock I, Sridhar S, Joshua A. Retreatment of men with metastatic castrate-resistant prostate cancer with abiraterone. Prostate 2014; 74:1462-4.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Prostate 2014; 74
Veröffentlichungsdatum
11.08.2014
eISSN (Online)
1097-0045
Seiten
1462-4
Kurzbeschreibung/Zielsetzung

BACKGROUND
Abiraterone acetate (AA), oral CYP17 inhibitor, is an active agent in the treatment of metastatic castrate-resistant prostate cancer (mCRPC).

METHODS
We (R.L.A and N.A) retrospectively evaluated outcome in 12 men who were re-treated with AA following prior treatment with AA at the Princess Margaret Cancer Centre.

RESULTS
All men were heavily pre-treated for mCRPC with a median of four prior lines of therapy, one of which was AA (given either pre- or post-chemotherapy). Eleven out of 12 (92%) men stopped their first treatment course of AA due to progression and one stopped for financial reasons. Seven men had a PSA decrease ≥50% following their first AA treatment, of which three (46%) had a PSA decrease ≥50% to AA re-treatment. The responses to AA re-treatment were generally short-lived with a median biochemical progression-free survival of 2.3 months and median treatment duration of 3.2 months. No PSA responses to AA re-treatment were seen in five men who did not have an initial PSA response to AA.

CONCLUSIONS
Our data suggest that AA re-challenge may have limited benefit in select men with mCRPC, and warrants further formal research.