Publikation

Perioperative detection of disseminated tumour cells is an independent prognostic factor in patients with colorectal cancer

Wissenschaftlicher Artikel/Review - 01.07.2003

Bereiche
PubMed
DOI

Zitation
Bösch B, Gueller U, Schnider A, Maurer R, Harder F, Metzger U, Marti W. Perioperative detection of disseminated tumour cells is an independent prognostic factor in patients with colorectal cancer. Br J Surg 2003; 90:882-8.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Br J Surg 2003; 90
Veröffentlichungsdatum
01.07.2003
ISSN (Druck)
0007-1323
Seiten
882-8
Kurzbeschreibung/Zielsetzung

BACKGROUND
The objective of the present investigation was to assess the prognostic significance of disseminated tumour cells in peritoneal lavage, and peripheral and mesenteric venous blood in patients undergoing curative resection of colorectal cancer.

METHODS
The prognostic impact of perioperative cytological and immunocytochemical detection of disseminated colorectal cancer cells was evaluated prospectively. Peritoneal lavage fluid, and peripheral and mesenteric venous blood from 53 consecutive patients undergoing curative surgery for colorectal cancer were analysed. The dichotomous results (positive versus negative) from the cytological and immunocytochemical analysis were used as a predictor along with other co-variates in proportional hazard regression models of disease-free and overall survival.

RESULTS
Disseminated colorectal cancer cells were found in 13 of 53 patients (25 per cent) using cytology (CYT) and/or immunocytochemistry (ICC). The median follow-up at the time of the analysis was 37 months. In multivariate proportional hazard regression models CYT/ICC status was a significant predictor for disease-free (P = 0.002) and overall (P = 0.006) survival.

CONCLUSION
Disseminated tumour cells detected by CYT and ICC represent an independent prognostic factor in patients undergoing surgery for colorectal cancer and may identify patients at high risk of recurrence.