Hepatitis B virus infection is associated with impaired immunological recovery during antiretroviral therapy in the Swiss HIV cohort study

Publikation

Hepatitis B virus infection is associated with impaired immunological recovery during antiretroviral therapy in the Swiss HIV cohort study

Wissenschaftlicher Artikel/Review - 30.07.2013

Wandeler Gilles, Rauch Andri, Furrer Hansjakob, Egger Matthias, Calmy Alexandra, Battegay Manuel, Schmid Patrick, Kovari Helen, Cavassini Matthias, Bernasconi Enos, Bihl Florian, Gsponer Thomas, Swiss HIV Cohort Study

Zitation

Wandeler G, Rauch A, Furrer H, Egger M, Calmy A, Battegay M, Schmid P, Kovari H, Cavassini M, Bernasconi E, Bihl F, Gsponer T, Swiss HIV Cohort Study. Hepatitis B virus infection is associated with impaired immunological recovery during antiretroviral therapy in the Swiss HIV cohort study. J Infect Dis 2013; 208:1454-8.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

J Infect Dis 2013; 208

Veröffentlichungsdatum

30.07.2013

eISSN (Online)

1537-6613

Seiten

1454-8

Kurzbeschreibung/Zielsetzung

Hepatitis B virus (HBV) infection is a major cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected patients worldwide. It is unclear whether HIV-related outcomes are affected by HBV coinfection. We compared virological suppression and immunological recovery during antiretroviral therapy (ART) of patients of different HBV serological status in the Swiss HIV Cohort Study. CD4 cell recovery during ART was significantly impaired in hepatitis B surface antigen-positive patients and in those with anti-hepatitis B core antigen alone compared with HBV-uninfected patients, despite similar virological efficacy of ART. CD4 increase in patients with resolved HBV infection was similar to that in HBV-uninfected individuals.