Publikation

Hydrocephalus in 389 patients with aneurysm-associated subarachnoid hemorrhage

Wissenschaftlicher Artikel/Review - 04.04.2013

Bereiche
PubMed
DOI

Zitation
Woernle C, Winkler K, Burkhardt J, Haile S, Bellut D, Neidert M, Bozinov O, Krayenbühl N, Bernays R. Hydrocephalus in 389 patients with aneurysm-associated subarachnoid hemorrhage. J Clin Neurosci 2013; 20:824-6.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
J Clin Neurosci 2013; 20
Veröffentlichungsdatum
04.04.2013
eISSN (Online)
1532-2653
Seiten
824-6
Kurzbeschreibung/Zielsetzung

Subarachnoid hemorrhage (SAH) often leads to hydrocephalus, which is commonly treated by placement of a ventriculoperitoneal (VP) shunt. There is controversy over which factors affect the need for such treatment. In this study, data were prospectively collected from 389 consecutive patients who presented with an aneurysm-associated SAH at a single center. External ventricular drainage placement was performed as part of the treatment for acute hydrocephalus, and VP shunts were placed in patients with chronic hydrocephalus. The data were retrospectively analyzed using two-sample t-tests, Fisher's exact test and logistic regression analysis. Overall, shunt dependency occurred in 91 of the 389 patients (23.4%). Using logistic regression analysis, two factors were found to be significantly associated with VP shunt placement: an initial Glasgow Coma Scale (GCS) score of 8-14 (8-14 versus 3-7, p = 0.016; 15 versus 3-7, p = 0.55); and aneurysm coiling (p = 0.017). Patients with an initial GCS score of 8-14 after aneurysm-associated SAH had a 2.5-fold higher risk of receiving a VP shunt than those with a GCS score of 3-7. Those with a GCS of 15 had a 50% lower risk of becoming shunt dependent than did the subgroup with a GCS score of 8-14. To clarify and strengthen these observations, prospective, randomized trials are needed.