Publikation

Relapse and subarachnoid dissemination of a pineal germinoma 14 years after radiation therapy

Wissenschaftlicher Artikel/Review - 01.05.1999

Bereiche
PubMed

Zitation
Von Rohr E, Gönner F, Schroth G, Cerny T. Relapse and subarachnoid dissemination of a pineal germinoma 14 years after radiation therapy. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 1999; 6:247-9.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 1999; 6
Veröffentlichungsdatum
01.05.1999
ISSN (Druck)
0967-5868
Seiten
247-9
Kurzbeschreibung/Zielsetzung

Intracranial germinomas are rare tumours which are highly curable with radiotherapy. In recent years treatment with chemotherapy has gained importance. Recurrence and dissemination is seen in about 10-20% of cases within the first 2 years after diagnosis; late recurrence and dissemination is very rare. We describe a patient with a recurrent germinoma 14 years after radiotherapy of a pineal tumour. We further report the management with chemotherapy, the late side effects of radiotherapy and the course of the disease with its fatal dissemination. We conclude that the use of radiotherapy, despite being highly effective, is clearly limited by its late side-effects. New regimens with chemotherapy seem promising but proved to be less effective in our case with tumour seeding throughout the subarachnoid space.