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Treatment of breast cancer is complex and needs multidisciplinarity. Preferably it should be performed in breast cancer units. Chemo-/endocrine treatment modalities are chosen by the targets (eg hormone receptors, Her2 receptor) and not by the risk any more (bi-annual St. Galler Konsensus meeting). The choice of local and systemic treatment should be adapted to the patient's conditions (age, co-morbidities, sometimes preferences) and must strongly consider the risk of relapse. Treatment of breast cancer patients is demanding and requires knowledge and skills, both of which is best available in breast cancer units.