Seroconversion to HCoV-NL63 in Rhesus Macaques

Publikation

Seroconversion to HCoV-NL63 in Rhesus Macaques

Wissenschaftlicher Artikel/Review - 30.10.2009

Dijkman Ronald, Mulder H Lie, Rumping Lynne, Kraaijvanger Ilse, Deijs Martin, Jebbink Maarten F, Verschoor Ernst J, van der Hoek Lia

Zitation

Dijkman R, Mulder H, Rumping L, Kraaijvanger I, Deijs M, Jebbink M, Verschoor E, van der Hoek L. Seroconversion to HCoV-NL63 in Rhesus Macaques. Viruses 2009; 1:647-56.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Viruses 2009; 1

Veröffentlichungsdatum

30.10.2009

eISSN (Online)

1999-4915

Seiten

647-56

Kurzbeschreibung/Zielsetzung

HCoV-NL63 is a recently identified respiratory virus. Its pathogenesis has not been fully unraveled because an animal model is currently lacking. Here we examined whether rhesus macaques encounter HCoV-NL63 infections during life, by examining the levels of antibodies to HCoV-NL63 in time. The animals were followed for 7 up till 19 years, and in three animals we observed a steep rise in antibodies during follow up, indicative of a natural infection with HCoV-NL63.