Lactate infusion during euglycemia but not hypoglycemia reduces subsequent food intake in healthy men

Publikation

Lactate infusion during euglycemia but not hypoglycemia reduces subsequent food intake in healthy men

Wissenschaftlicher Artikel/Review - 28.01.2012

Schultes Bernd, Schmid Sebastian M, Wilms Britta, Jauch-Chara Kamila, Oltmanns Kerstin M, Hallschmid Manfred

Zitation

Schultes B, Schmid S, Wilms B, Jauch-Chara K, Oltmanns K, Hallschmid M. Lactate infusion during euglycemia but not hypoglycemia reduces subsequent food intake in healthy men. Appetite 2012; 58:818-821.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Appetite 2012; 58

Veröffentlichungsdatum

28.01.2012

eISSN (Online)

1095-8304

Seiten

818-821

Kurzbeschreibung/Zielsetzung

Considering that lactate is known to interact with central glucose-sensing networks, we tested whether hyperlactatemia affects food intake in humans. According to a balanced within-subject 2×2 design, 12 healthy, fasted men (age: 20-40years; BMI: 20-26kg/m(2)) were intravenously infused lactate and saline, respectively, for 105min during concomitant euglycemic and hypoglycemic, respectively, insulin infusion of 75min. Ten minutes after the simultaneous end of infusions, free-choice food intake was assessed at 10:25h. Lactate decreased food intake following euglycemia as compared to the other three conditions in which food intake did not differ. Results point to an anorexigenic effect of lactate under euglycemic conditions.