Publikation

CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity

Wissenschaftlicher Artikel/Review - 01.04.2005

Bereiche
PubMed
DOI

Zitation
Nieuwenhuis E, Blumberg R, Dranoff G, Strominger J, Balk S, Taniguchi M, Exley M, Scheper R, Gillessen Sommer S, Wilson S. CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity. Experimental dermatology 2005; 14:250-8.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Experimental dermatology 2005; 14
Veröffentlichungsdatum
01.04.2005
ISSN (Druck)
0906-6705
Seiten
250-8
Kurzbeschreibung/Zielsetzung

CD1d-restricted T-cells are activated by glycolipids presented by the major histocompatibility complex class-Ib molecule CD1d, found on the surface of antigen-presenting cells (APC). This interaction between APC, most notably dendritic cells (DC), and CD1d-restricted T-cells is an important regulatory step in the initiation of adaptive immune responses. It is well known that DC play a crucial role in the induction of contact hypersensitivity (CHS), a frequently studied form of in vivo T-cell-mediated immunity. In this study, we show that CD1d-restricted T-cells are also necessary for CHS, because both wild-type mice treated systemically or topically with CD1d glycolipid antagonists and CD1d-restricted T-cell-null mice have markedly diminished CHS responses. Thus, pharmacologic antagonists of CD1d can be used as effective inhibitors of CHS, a prototype for a variety of delayed-type tissue hypersensitivity responses.