Effectiveness of protease inhibitor monotherapy versus combination antiretroviral maintenance therapy: a meta-analysis

Publikation

Effectiveness of protease inhibitor monotherapy versus combination antiretroviral maintenance therapy: a meta-analysis

Wissenschaftlicher Artikel/Review - 19.07.2011

Mathis Sandra, Arribas Jose, Meynard Jean-Luc, Cahn Pedro, Vernazza Pietro, Nelson Mark, Negredo Eugenia, Schechter Mauro, Pulido Federico, Khanlari Bettina, Bucher Heiner C

Zitation

Mathis S, Arribas J, Meynard J, Cahn P, Vernazza P, Nelson M, Negredo E, Schechter M, Pulido F, Khanlari B, Bucher H. Effectiveness of protease inhibitor monotherapy versus combination antiretroviral maintenance therapy: a meta-analysis. PloS one 2011; 6:e22003.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

PloS one 2011; 6

Veröffentlichungsdatum

19.07.2011

eISSN (Online)

1932-6203

Seiten

e22003

Kurzbeschreibung/Zielsetzung

The unparalleled success of combination antiretroviral therapy (cART) is based on the combination of three drugs from two classes. There is insufficient evidence whether simplification to ritonavir boosted protease inhibitor (PI/r) monotherapy in virologically suppressed HIV-infected patients is effective and safe to reduce cART side effects and costs.