Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma

Publikation

Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma

Wissenschaftlicher Artikel/Review - 17.01.2007

Semela David, Piguet Anne-Christine, Kolev Mirjam, Schmitter Karin, Hlushchuk Ruslan, Djonov Valentin, Stoupis Christoforos, Dufour Jean-François

Zitation

Semela D, Piguet A, Kolev M, Schmitter K, Hlushchuk R, Djonov V, Stoupis C, Dufour J. Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma. J Hepatol 2007; 46:840-8.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

J Hepatol 2007; 46

Veröffentlichungsdatum

17.01.2007

ISSN (Druck)

0168-8278

Seiten

840-8

Kurzbeschreibung/Zielsetzung

Hepatocellular carcinoma (HCC) is amenable to only few treatments. Inhibitors of the kinase mTOR are a new class of immunosuppressors already in use after liver transplantation. Their antiproliferative and antiangiogenic properties suggest that these drugs could be considered to treat HCC. We investigated the antitumoral effects of mTOR inhibition in a HCC model.