The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses

Publikation

The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses

Wissenschaftlicher Artikel/Review - 27.04.2011

Kuri Thomas, Ziebuhr John, Thiel Volker, Siddell Stuart G, Davidson Andrew D, Snijder Eric J, Züst Roland, Putics Akos, Eriksson Klara K, Weber Friedemann

Zitation

Kuri T, Ziebuhr J, Thiel V, Siddell S, Davidson A, Snijder E, Züst R, Putics A, Eriksson K, Weber F. The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses. J Gen Virol 2011; 92:1899-905.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

J Gen Virol 2011; 92

Veröffentlichungsdatum

27.04.2011

eISSN (Online)

1465-2099

Seiten

1899-905

Kurzbeschreibung/Zielsetzung

Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1?-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to the antiviral effect of alpha interferon compared with their wild-type counterparts. The data suggest that macrodomain-associated ADRP activities may have a role in viral escape from the innate immune responses of the host.