C-reactive protein in the arterial intima: role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis

Publikation

C-reactive protein in the arterial intima: role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis

Wissenschaftlicher Artikel/Review - 01.09.2000

Torzewski Michael, Rist C, Mortensen R F, Zwaka T P, Bienek M, Waltenberger J, Koenig W, Schmitz G, Hombach V

PubMed

Zitation

Torzewski M, Rist C, Mortensen R, Zwaka T, Bienek M, Waltenberger J, Koenig W, Schmitz G, Hombach V. C-reactive protein in the arterial intima: role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis. Arterioscler Thromb Vasc Biol 2000; 20:2094-9.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Arterioscler Thromb Vasc Biol 2000; 20

Veröffentlichungsdatum

01.09.2000

eISSN (Online)

1524-4636

Seiten

2094-9

Kurzbeschreibung/Zielsetzung

Infiltration of monocytes into the arterial wall is an early cellular event in atherogenesis. Recent evidence shows that C-reactive protein (CRP) is deposited in the arterial intima at sites of atherogenesis. In this study, we demonstrate that CRP deposition precedes the appearance of monocytes in early atherosclerotic lesions. CRP is chemotactic for freshly isolated human blood monocytes. A specific CRP receptor is demonstrated on monocytes in vitro as well as in vivo, and blockage of the receptor by use of a monoclonal anti-receptor antibody completely abolishes CRP-induced chemotaxis. CRP may play a major role in the recruitment of monocytes during atherogenesis.