Publikation
Midregional pro-A-type natriuretic peptide for the evaluation of exercise intolerance
Wissenschaftlicher Artikel/Review - 22.12.2009
Maeder Micha, Bergmann Andreas, Morgenthaler Nils G, Reichlin Tobias, Potocki Mihael, Schaub Nora, Breidthardt Tobias, Noveanu Markus, Staub Daniel, Christ Andreas, Brutsche Martin, Mueller Christian
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Kurzbeschreibung/Zielsetzung
The aim of this study was to determine the accuracy of midregional pro-A-type natriuretic peptide (MR-proANP) for the identification of a cardiocirculatory exercise limitation (CL) as assessed by cardiopulmonary exercise testing (CPET) and to compare it to B-type natriuretic peptide (BNP). Among 94 patients with CPET data fulfilling criteria for appropriate effort and sufficient diagnostic certainty, 27 (29%) had CL. The areas under the receiver-operator-characteristic curve for MR-proANP and BNP to identify CL were 0.84 and 0.79 respectively (p=0.17). In conclusion, MR-proANP had a comparable accuracy to BNP for the identification of CL and might be a valuable assistance for the differentiation of exercise intolerance.