Publikation
Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study
Wissenschaftlicher Artikel/Review - 11.01.2010
Rauch Andri, Hirschel Bernard, Malinverni Raffaele, Moradpour Darius, Mullhaupt Beat, Witteck Andrea, Beckmann Jacques S, Berg Thomas, Bergmann Sven, Negro Francesco, Telenti Amalio, Bochud Pierre-Yves, Swiss Hepatitis C Cohort Study, Heim Markus, Günthard Huldrych F, Furrer Hansjakob, Kutalik Zoltán, Descombes Patrick, Cai Tao, di Iulio Julia, Mueller Tobias, Bochud Murielle, Battegay Manuel, Bernasconi Enos, Borovicka Jan, Colombo Sara, Cerny Andreas, Dufour Jean-François, Swiss HIV Cohort Study
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Hepatitis C virus (HCV) induces chronic infection in 50% to 80% of infected persons; approximately 50% of these do not respond to therapy. We performed a genome-wide association study to screen for host genetic determinants of HCV persistence and response to therapy.